01 January 2001
Nitric oxide synthase type 1 expression in human lung cancer and its relation to p53.
Barbara Lewko, Albina Zółtowska, Jan Stepiński, Maciej Kamiński, Jan Skokowski, Andrzej Roszkiewicz, Grażyna MoszkowskaMed Sci Monit 2001; 7(2): BR218-221 :: ID: 421160
Abstract
BACKGROUND: The nitric oxide synthases (NOS) have been observed in humantumour cell lines as well as in solid tumours. Neuronal isoform of NOS (NOS1) was particularly abundantin low-differentiated gynaecological, breast and central nerve system tumours, suggesting that it maycharacterize poorly differentiated tumours. So far, little is known about expression of the neuronalNOS isoform in non-small cell lung cancer. Our aim was to compare NOS1 expression in non-small lung carcinomaswith respect to tumor staging and p53 protein expression.
MATERIAL AND METHODS: Thirty-two cases of non-smalllung carcinomas of all grades of malignancy and ten control lung specimens with neoplastic lesions wereexamined. Paraffin-embedded tissues were stained with hematoxylin and eosin, or with antibodies to NOS1and p53, and evaluated under light microscope.
RESULTS: No statistical correlation between expressionof p53, NOS1 and degree od tumour differentiation was observed.
CONCLUSION: Expression of NOS1 can notserve as a marker for highly malignant tumours in the non-small cell lung carcinomas.
Keywords: NOS1, granular pattern, perinuclear bead-like pattern, lung cancers
Editorial
01 May 2024 : Editorial
Editorial: First Regulatory Approval for Adoptive Cell Therapy with Autologous Tumor-Infiltrating Lymphocytes (TILs) – Lifileucel (Amtagvi)DOI: 10.12659/MSM.944927
Med Sci Monit 2024; 30:e944927
In Press
12 Mar 2024 : Clinical Research
Preoperative Blood Transfusion Requirements for Hemorrhoidal Severe Anemia: A Retrospective Study of 128 Pa...Med Sci Monit In Press; DOI: 10.12659/MSM.943126
12 Mar 2024 : Clinical Research
Tissue Inhibitors of Metalloproteinase 1 (TIMP-1) and 3 (TIMP-3) as New Markers of Acute Kidney Injury Afte...Med Sci Monit In Press; DOI: 10.12659/MSM.943500
12 Mar 2024 : Review article
Optimizing Behçet Uveitis Management: A Review of Personalized Immunosuppressive StrategiesMed Sci Monit In Press; DOI: 10.12659/MSM.943240
12 Mar 2024 : Clinical Research
Metabolomic Alterations in Methotrexate Treatment of Moderate-to-Severe PsoriasisMed Sci Monit In Press; DOI: 10.12659/MSM.943360
Most Viewed Current Articles
17 Jan 2024 : Review article
Vaccination Guidelines for Pregnant Women: Addressing COVID-19 and the Omicron VariantDOI :10.12659/MSM.942799
Med Sci Monit 2024; 30:e942799
14 Dec 2022 : Clinical Research
Prevalence and Variability of Allergen-Specific Immunoglobulin E in Patients with Elevated Tryptase LevelsDOI :10.12659/MSM.937990
Med Sci Monit 2022; 28:e937990
16 May 2023 : Clinical Research
Electrophysiological Testing for an Auditory Processing Disorder and Reading Performance in 54 School Stude...DOI :10.12659/MSM.940387
Med Sci Monit 2023; 29:e940387
01 Jan 2022 : Editorial
Editorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Pa...DOI :10.12659/MSM.935952
Med Sci Monit 2022; 28:e935952