01 November 2005
Changes in Body Composition and Insulin Sensitivity in Severely Obese Subjects After Laparoscopic Adjustable Silicone Gastric Banding (LASGB).
Gabriella Garrapa, Paola Canibus, Cristina Gatti, Milena Santangelo, Federica Frezza, Francesco Feliciotti, Marco Boscaro, Emanuela FaloiaDOI: 10.12659/MSM.430365
Med Sci Monit 2005; 11(11): CR522-528
Abstract
Background: Laparoscopic adjustable silicone gastric banding (LASGB) isa viable therapeutic approach to achieve stable body weight reduction in severe obesity. The aim of thisstudy was to evaluate body composition and metabolic features in morbidly obese patients before and afterLASGB. Material/Methods: There were 15 severely obese patients (Ob) (M/F: 4/11; mean age: 32.5+/-3.8years) and 16 age- and sex-matched healthy lean controls (C) (M/F: 4/12; mean age: 39.5+/-2 years). Bodymass index (BMI), waist circumference, waist-to-hip ratio, blood pressure, lipid profile, serum glucoseand insulin during OGTT, and HOMA-IR were evaluated in all subjects. Body composition and fat distributionwere measured using dual energy X-ray absorptiometry (DEXA). Patients were assessed before and six monthsafter LASGB. Results: The obese subjects showed several metabolic alterations. There were also positivecorrelations between waist, fat mass (FM), and HOMA-IR at baseline. After LASGB, mean BMI fell from 42.2kg/m(2) to 33.2 kg/m(2); waist circumference and abdominal FM% decreased significantly. FM% declined,whereas FFM% increased. The ratio of FM loss to FFM loss was 3.7:1. Serum glucose and insulin levelsduring OGTT diminished slightly after weight loss and triglyceride levels fell dramatically. After LASGB,fasting insulin and HOMA-IR declined. Conclusions: LASGB induced a significant improvement in insulinsensitivity and a redistribution of body composition with a relative increase of FFM.
Keywords: Anthropometry, Absorptiometry, Photon, Body Composition, Gastroplasty - methods, Insulin Resistance, Laparoscopy, Obesity, Morbid - therapy, Silicones, Stomach - surgery, Weight Loss
Editorial
01 May 2024 : Editorial
Editorial: First Regulatory Approval for Adoptive Cell Therapy with Autologous Tumor-Infiltrating Lymphocytes (TILs) – Lifileucel (Amtagvi)DOI: 10.12659/MSM.944927
Med Sci Monit 2024; 30:e944927
In Press
12 Mar 2024 : Clinical Research
Preoperative Blood Transfusion Requirements for Hemorrhoidal Severe Anemia: A Retrospective Study of 128 Pa...Med Sci Monit In Press; DOI: 10.12659/MSM.943126
12 Mar 2024 : Clinical Research
Tissue Inhibitors of Metalloproteinase 1 (TIMP-1) and 3 (TIMP-3) as New Markers of Acute Kidney Injury Afte...Med Sci Monit In Press; DOI: 10.12659/MSM.943500
12 Mar 2024 : Review article
Optimizing Behçet Uveitis Management: A Review of Personalized Immunosuppressive StrategiesMed Sci Monit In Press; DOI: 10.12659/MSM.943240
12 Mar 2024 : Clinical Research
Metabolomic Alterations in Methotrexate Treatment of Moderate-to-Severe PsoriasisMed Sci Monit In Press; DOI: 10.12659/MSM.943360
Most Viewed Current Articles
17 Jan 2024 : Review article
Vaccination Guidelines for Pregnant Women: Addressing COVID-19 and the Omicron VariantDOI :10.12659/MSM.942799
Med Sci Monit 2024; 30:e942799
14 Dec 2022 : Clinical Research
Prevalence and Variability of Allergen-Specific Immunoglobulin E in Patients with Elevated Tryptase LevelsDOI :10.12659/MSM.937990
Med Sci Monit 2022; 28:e937990
16 May 2023 : Clinical Research
Electrophysiological Testing for an Auditory Processing Disorder and Reading Performance in 54 School Stude...DOI :10.12659/MSM.940387
Med Sci Monit 2023; 29:e940387
01 Jan 2022 : Editorial
Editorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Pa...DOI :10.12659/MSM.935952
Med Sci Monit 2022; 28:e935952