01 March 2006
The Role of Aspirin Versus Aspirin and Heparin in Cases of Recurrent Abortions with Raised Anticardiolipin Antibodies
Neha Goel, Anita Tuli, Rewa ChoudhryMed Sci Monit 2006; 12(3): CS132-136 :: ID: 447112
Abstract
Background: The present study was undertaken to compare the role of aspirinversus aspirin plus heparin combination in pregnant women with poor obstetric history and raised anticardiolipinantibodies IgG (IgG[sub]acl[/sub]). Material/Methods: The study was conducted on 550 pregnant women, 450 witha history of two or more spontaneous abortions forming the study group, while 100 women with one or morelive births and no history of abortion were controls. Their blood was tested to assess the level of IgG[sub]acl[/sub] by enzyme-linked immunosorbent assay (ELISA). The test was strongly positive in 72 (16%) patients ofthe study group, who were randomized to receive either low-dose aspirin (80 mg/day) or a combinationof low-dose aspirin (80 mg/day) and 5000 IU of unfractionated heparin subcutaneously 12 hourly underhospital surveillance. The pregnancy outcomes were statistically compared. Results: Of the 39 patientstreated with low-dose aspirin, 24 (61.5%) gave birth to live issues compared with 28 (84.8%) of the 33women given a combination of aspirin and heparin (p
Keywords: Abortion, Habitual - prevention & control, Antibodies, Anticardiolipin - blood, Anticoagulants - therapeutic use, Apgar Score, Aspirin - therapeutic use, Birth Weight, Drug Therapy, Combination, Heparin - therapeutic use, Immunoglobulin G - blood, Infant, Newborn, Live Birth, Pregnancy, Pregnancy Outcome
Editorial
01 May 2024 : Editorial
Editorial: First Regulatory Approval for Adoptive Cell Therapy with Autologous Tumor-Infiltrating Lymphocytes (TILs) – Lifileucel (Amtagvi)DOI: 10.12659/MSM.944927
Med Sci Monit 2024; 30:e944927
In Press
12 Mar 2024 : Database Analysis
Risk Factors of Age-Related Macular Degeneration in a Population-Based Study: Results from SHIP-TREND-1 (St...Med Sci Monit In Press; DOI: 10.12659/MSM.943140
12 Mar 2024 : Clinical Research
Preoperative Blood Transfusion Requirements for Hemorrhoidal Severe Anemia: A Retrospective Study of 128 Pa...Med Sci Monit In Press; DOI: 10.12659/MSM.943126
12 Mar 2024 : Clinical Research
Tissue Inhibitors of Metalloproteinase 1 (TIMP-1) and 3 (TIMP-3) as New Markers of Acute Kidney Injury Afte...Med Sci Monit In Press; DOI: 10.12659/MSM.943500
12 Mar 2024 : Review article
Optimizing Behçet Uveitis Management: A Review of Personalized Immunosuppressive StrategiesMed Sci Monit In Press; DOI: 10.12659/MSM.943240
Most Viewed Current Articles
17 Jan 2024 : Review article
Vaccination Guidelines for Pregnant Women: Addressing COVID-19 and the Omicron VariantDOI :10.12659/MSM.942799
Med Sci Monit 2024; 30:e942799
14 Dec 2022 : Clinical Research
Prevalence and Variability of Allergen-Specific Immunoglobulin E in Patients with Elevated Tryptase LevelsDOI :10.12659/MSM.937990
Med Sci Monit 2022; 28:e937990
16 May 2023 : Clinical Research
Electrophysiological Testing for an Auditory Processing Disorder and Reading Performance in 54 School Stude...DOI :10.12659/MSM.940387
Med Sci Monit 2023; 29:e940387
01 Jan 2022 : Editorial
Editorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Pa...DOI :10.12659/MSM.935952
Med Sci Monit 2022; 28:e935952