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The effect of caffeic acid phenethyl ester on short-term acute myocardial ischemia.

Haluk Ince, Eyup Kandemir, Cahit Bagci, Mukaddes Gulec, Omer Akyol

Med Sci Monit 2006; 12(5): BR187-193

ID: 450285


Background: We previously showed that caffeic acid phenethyl ester (CAPE)attenuated NO production, reduced apoptosis, diminished serum CK and AST activities, and is cardio-protectivein rat heart subjected to ischemia/reperfusion (I/R). We now studied the short-term cardio-protectiveeffect of CAPE in an I/R rat heart model. Material/Methods: Wistar rats were divided into four groups:(i) sham-operated, (ii) I/R, (iii) I/R+CAPE, and (iv) I/R+glutathione. CAPE (10 micromol/kg) was infusedi.v. 10 min before occlusion of the left anterior descending coronary artery (8 min) followed by reperfusion(8 min). Results: SOD (p

Keywords: Malondialdehyde - metabolism, Xanthine Oxidase - metabolism, Superoxide Dismutase - metabolism, Rats, Wistar, Rats, Phenylethyl Alcohol - pharmacology, Nitric Oxide - metabolism, Myocardial Reperfusion Injury - prevention & control, Myocardial Ischemia - metabolism, Animals, Male, Glutathione Peroxidase - metabolism, Catalase - metabolism, Cardiotonic Agents - pharmacology, Caffeic Acids - pharmacology, Antioxidants - metabolism, Acute Disease, Adenosine Deaminase - metabolism