01 March 1996
Reactivity of the central dopamine (DA) and serotonine (5-HT) receptors during development and aging of rats
Ryszard Brus, Ryszard Szkilnik, Urszula Mikołajun, Włodzisława TramerMed Sci Monit 1996; 2(2): BR129-133 :: ID: 499544
Abstract
Changes of the central neuronal systems are important manifestation of many neurological disturbances, mainly of the old age. The aim of the study was to examine reactivity of D1,D3, central dopamine (DA) and serotonin 5-HT2C, receptors during ontogenic development in rats. For this purpose we have used specific receptor agonist and behavioral procedures such as oral activity and yawning. Male Wistar rats were challenged intraperitoneally with D1, central DA agonist - SKF 38393: 0.03 -1.0; D2,/D3, central DA agonist - quinpirole: 0.0125 - 0.2 or 5-HT2C, agonist - mCPP (m-chlorphenyl-piperazine): 0.3-6.0 mg/kg. This procedure was repeated every month since the 1st till the 16-18th month of postnatal life. Number of oral movements or yawns was recorded during one hour observation period. On the basis of these results we can conclude that during the aging process in rats, reactivity of D1, central DA and 5-HT2C, receptors is decreased. D3, central dopamine receptor reactivity is increased in the second month of life, then decreased as aging progress.
Keywords: dopamine receptors, serotonin receptors, SKF 38393, aging process
Editorial
01 April 2024 : Editorial
Editorial: Forty Years of Waiting for Prevention and Cure of HIV Infection – Ongoing Challenges and Hopes for Vaccine Development and Overcoming Antiretroviral Drug ResistanceDOI: 10.12659/MSM.944600
Med Sci Monit 2024; 30:e944600
In Press
07 Mar 2024 : Clinical Research
Knowledge of and Attitudes Toward Clinical Trials: A Questionnaire-Based Study of 179 Male Third- and Fourt...Med Sci Monit In Press; DOI: 10.12659/MSM.943468
08 Mar 2024 : Animal Research
Modification of Experimental Model of Necrotizing Enterocolitis (NEC) in Rat Pups by Single Exposure to Hyp...Med Sci Monit In Press; DOI: 10.12659/MSM.943443
18 Apr 2024 : Clinical Research
Comparative Analysis of Open and Closed Sphincterotomy for the Treatment of Chronic Anal Fissure: Safety an...Med Sci Monit In Press; DOI: 10.12659/MSM.944127
08 Mar 2024 : Laboratory Research
Evaluation of Retentive Strength of 50 Endodontically-Treated Single-Rooted Mandibular Second Premolars Res...Med Sci Monit In Press; DOI: 10.12659/MSM.944110
Most Viewed Current Articles
17 Jan 2024 : Review article
Vaccination Guidelines for Pregnant Women: Addressing COVID-19 and the Omicron VariantDOI :10.12659/MSM.942799
Med Sci Monit 2024; 30:e942799
14 Dec 2022 : Clinical Research
Prevalence and Variability of Allergen-Specific Immunoglobulin E in Patients with Elevated Tryptase LevelsDOI :10.12659/MSM.937990
Med Sci Monit 2022; 28:e937990
16 May 2023 : Clinical Research
Electrophysiological Testing for an Auditory Processing Disorder and Reading Performance in 54 School Stude...DOI :10.12659/MSM.940387
Med Sci Monit 2023; 29:e940387
01 Jan 2022 : Editorial
Editorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Pa...DOI :10.12659/MSM.935952
Med Sci Monit 2022; 28:e935952