03 March 1997
Estimation of early toxicity induced by cytostatic agents used in the chemotherapy of childhood neoplasms
Danuta Kurylak, Andrzej Kurylak, Mariusz Wysocki, Anna Balcar-BorońMed Sci Monit 1997; 3(2): PI266-273 :: ID: 500725
Abstract
In the study we examined the incidence of adverse effects and their severity expressed on the WHO scale as well as of early toxicity induced by cytostatic agents used in the chemotherapy of 109 children with neoplasms treated in the years 1988-1993. The incidents of myelosuppression and related neutropenia and infections predominated in that group of patients. Compared to earlier periods the incidence of toxic complications involving the liver, gasto-intestinal mucasa and kidneys increased. Other adverse effects occurred only occasionally, but not infrequently they were life-threatening. Ara-C was responsible for the most incidents of severe symptoms of myelosuppression and vomiting, while hepatoxicity and toxic damage to the gastro-intesinal mucosa was mostly due to MTX. Symptoms of allergy were the most frequently observed following the treatment with L-aspa and MTX. The incidence of toxic central nervous system complications was the same after Ara-C, CY, ACTD and VCR. Occasional pancreatic complications could be related to the treatment with L-aspa. The cytostatics which caused the significantly most severe complications according to the WHO scale were Ara-C, MTX, VCR, CY and ADM.
Keywords: cytostatic agents, toxicity, childhood neoplasms
Editorial
01 May 2024 : Editorial
Editorial: First Regulatory Approval for Adoptive Cell Therapy with Autologous Tumor-Infiltrating Lymphocytes (TILs) – Lifileucel (Amtagvi)DOI: 10.12659/MSM.944927
Med Sci Monit 2024; 30:e944927
In Press
12 Mar 2024 : Database Analysis
Risk Factors of Age-Related Macular Degeneration in a Population-Based Study: Results from SHIP-TREND-1 (St...Med Sci Monit In Press; DOI: 10.12659/MSM.943140
12 Mar 2024 : Clinical Research
Preoperative Blood Transfusion Requirements for Hemorrhoidal Severe Anemia: A Retrospective Study of 128 Pa...Med Sci Monit In Press; DOI: 10.12659/MSM.943126
12 Mar 2024 : Clinical Research
Tissue Inhibitors of Metalloproteinase 1 (TIMP-1) and 3 (TIMP-3) as New Markers of Acute Kidney Injury Afte...Med Sci Monit In Press; DOI: 10.12659/MSM.943500
12 Mar 2024 : Review article
Optimizing Behçet Uveitis Management: A Review of Personalized Immunosuppressive StrategiesMed Sci Monit In Press; DOI: 10.12659/MSM.943240
Most Viewed Current Articles
17 Jan 2024 : Review article
Vaccination Guidelines for Pregnant Women: Addressing COVID-19 and the Omicron VariantDOI :10.12659/MSM.942799
Med Sci Monit 2024; 30:e942799
14 Dec 2022 : Clinical Research
Prevalence and Variability of Allergen-Specific Immunoglobulin E in Patients with Elevated Tryptase LevelsDOI :10.12659/MSM.937990
Med Sci Monit 2022; 28:e937990
16 May 2023 : Clinical Research
Electrophysiological Testing for an Auditory Processing Disorder and Reading Performance in 54 School Stude...DOI :10.12659/MSM.940387
Med Sci Monit 2023; 29:e940387
01 Jan 2022 : Editorial
Editorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Pa...DOI :10.12659/MSM.935952
Med Sci Monit 2022; 28:e935952