01 May 1997
Haemopexin and uptake of haem by human erythroleukemia (HEL) cells
Hana Cajthamlova, Zbynek Hrkal, Dana Grebenova, Ursula Muller-Eberhard, Richard J. StockertMed Sci Monit 1997; 3(3): BR305-312 :: ID: 500777
Abstract
Uncomplexed haem suppresses the proliferation of human erythroleukemia (HEL) cells, the effect of which can be partially reversed by apo-haemopexin. The process of suppressed proliferation is paralleled by differentiation of the HEL cells accompanied by haemoglobin synthesis. Equivalent amounts of haem supplied to the cells in the form of haem-haemopexin neither affected their proliferation nor promoted haemoglobin synthesis. Haemopexin internalization by HEL cells only occurred if the haem-haemopexin complexes were continuously supplied to the cells at 37 °C. It suggests that fluid flow endocytosis rather than receptor mediated endocytosis is operative in this process.
Keywords: haem, haemopexin, HEL, proliferation, receptor
Editorial
01 May 2024 : Editorial
Editorial: First Regulatory Approval for Adoptive Cell Therapy with Autologous Tumor-Infiltrating Lymphocytes (TILs) – Lifileucel (Amtagvi)DOI: 10.12659/MSM.944927
Med Sci Monit 2024; 30:e944927
In Press
12 Mar 2024 : Clinical Research
Preoperative Blood Transfusion Requirements for Hemorrhoidal Severe Anemia: A Retrospective Study of 128 Pa...Med Sci Monit In Press; DOI: 10.12659/MSM.943126
12 Mar 2024 : Clinical Research
Tissue Inhibitors of Metalloproteinase 1 (TIMP-1) and 3 (TIMP-3) as New Markers of Acute Kidney Injury Afte...Med Sci Monit In Press; DOI: 10.12659/MSM.943500
12 Mar 2024 : Review article
Optimizing Behçet Uveitis Management: A Review of Personalized Immunosuppressive StrategiesMed Sci Monit In Press; DOI: 10.12659/MSM.943240
12 Mar 2024 : Clinical Research
Metabolomic Alterations in Methotrexate Treatment of Moderate-to-Severe PsoriasisMed Sci Monit In Press; DOI: 10.12659/MSM.943360
Most Viewed Current Articles
17 Jan 2024 : Review article
Vaccination Guidelines for Pregnant Women: Addressing COVID-19 and the Omicron VariantDOI :10.12659/MSM.942799
Med Sci Monit 2024; 30:e942799
14 Dec 2022 : Clinical Research
Prevalence and Variability of Allergen-Specific Immunoglobulin E in Patients with Elevated Tryptase LevelsDOI :10.12659/MSM.937990
Med Sci Monit 2022; 28:e937990
16 May 2023 : Clinical Research
Electrophysiological Testing for an Auditory Processing Disorder and Reading Performance in 54 School Stude...DOI :10.12659/MSM.940387
Med Sci Monit 2023; 29:e940387
01 Jan 2022 : Editorial
Editorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Pa...DOI :10.12659/MSM.935952
Med Sci Monit 2022; 28:e935952