01 July 1998
Superoxide dismutase isoenzymes activity changes in the plasma of heart failure patients
Wojciech Jacheć, Lech Poloński, Barbara Kuśnierz, Roman Tarnowski, Jan Wodnicki, Michał Tendera, Andrzej TomasikMed Sci Monit 1998; 4(4): CR646-650 :: ID: 502284
Abstract
46 patients (19 women and 27 men, aged 42±14 years) with congestive cardiomyopathy (left ventricular ejection
fraction < 30%) and 10 healthy subjects (aged 36±12 years) were evaluated echocardiographically.Plasma activities of MnSOD and CuZnSOD were measured. A statistically significant negative correlation was found between MnSOD activity and the CI (r=0.64). The mean MnSOD activity in patients with the CI<2.41/min/m2 was 16.58±5.82 NU/I, and in patients with the CI>2.41/min/m2 it was 9.92±3.28NU/I (p<0.001). The mean CuZnSOP activity in patients with the CI<2.41/min/m2 was 4.5NU/I and in patients with CI>2.41/min/m2 it was 6.9±2.32 (p<0.01). The activity of MnSOD and CuZnSOD in healthy subjects was comparable to that found in patients with the CI>2.41/min/m2. Patients with the CI<2.41/min/m2 were reexamined following 6 weeks of pharmacological treatment (Drugs used: digoxin, captopril, furosemide, isosorbide dinitrate). A significant increase of the CI (p<0.01) accompanied by a decrease of MnSOD activity (p<0.05), and an insignificant increase of CuZnSOD activity were found. Our results indirectly confirm the increase of oxygen free radical concentration levels in patients with heart failure.
Keywords: cardiomyopathy, Free Radicals, Isoenzymes
Editorial
01 May 2024 : Editorial
Editorial: First Regulatory Approval for Adoptive Cell Therapy with Autologous Tumor-Infiltrating Lymphocytes (TILs) – Lifileucel (Amtagvi)DOI: 10.12659/MSM.944927
Med Sci Monit 2024; 30:e944927
In Press
12 Mar 2024 : Database Analysis
Risk Factors of Age-Related Macular Degeneration in a Population-Based Study: Results from SHIP-TREND-1 (St...Med Sci Monit In Press; DOI: 10.12659/MSM.943140
12 Mar 2024 : Clinical Research
Preoperative Blood Transfusion Requirements for Hemorrhoidal Severe Anemia: A Retrospective Study of 128 Pa...Med Sci Monit In Press; DOI: 10.12659/MSM.943126
12 Mar 2024 : Clinical Research
Tissue Inhibitors of Metalloproteinase 1 (TIMP-1) and 3 (TIMP-3) as New Markers of Acute Kidney Injury Afte...Med Sci Monit In Press; DOI: 10.12659/MSM.943500
12 Mar 2024 : Review article
Optimizing Behçet Uveitis Management: A Review of Personalized Immunosuppressive StrategiesMed Sci Monit In Press; DOI: 10.12659/MSM.943240
Most Viewed Current Articles
17 Jan 2024 : Review article
Vaccination Guidelines for Pregnant Women: Addressing COVID-19 and the Omicron VariantDOI :10.12659/MSM.942799
Med Sci Monit 2024; 30:e942799
14 Dec 2022 : Clinical Research
Prevalence and Variability of Allergen-Specific Immunoglobulin E in Patients with Elevated Tryptase LevelsDOI :10.12659/MSM.937990
Med Sci Monit 2022; 28:e937990
16 May 2023 : Clinical Research
Electrophysiological Testing for an Auditory Processing Disorder and Reading Performance in 54 School Stude...DOI :10.12659/MSM.940387
Med Sci Monit 2023; 29:e940387
01 Jan 2022 : Editorial
Editorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Pa...DOI :10.12659/MSM.935952
Med Sci Monit 2022; 28:e935952