01 February 2005
Ceruloplasmin - acute-phase reactant or endogenous antioxidant? The case of cardiovascular disease.
Natalia Giurgea, Mihaela Ioana Constantinescu, Ramona Stanciu, Soimita Suciu, Adriana MuresanMed Sci Monit 2005; 11(2): RA48-51 :: ID: 14230
Abstract
Ceruloplasmin is a plasma protein that functions as a copper transporter. Epidemiological studies have indicated an association between the concentration of this protein and risk for cardiovascular disease. The mechanism for the involvement of ceruloplasmin in cardiovascular disease and other conditions is not yet clear, although it is widely accepted that the role played by ceruloplasmin in facilitating or counteracting oxidative stress is central. We review here some of the studies on this issue and try to calm down the duel between the claims supporting the oxidant or the antioxidant effects of ceruloplasmin through a clear-cut analysis of the available data. Our conclusion is that a verdict regarding the pathogenetic involvement of ceruloplasmin in cardiovascular disease should await further research.
Keywords: Acute-Phase Reaction, Antioxidants - metabolism, Cardiovascular Diseases - metabolism, Ceruloplasmin - chemistry, Ceruloplasmin - metabolism, Lipoproteins - metabolism, Acute-Phase Reaction, Antioxidants - metabolism, Cardiovascular Diseases - metabolism, Ceruloplasmin - metabolism, Lipoproteins - metabolism
Editorial
01 April 2024 : Editorial
Editorial: Forty Years of Waiting for Prevention and Cure of HIV Infection – Ongoing Challenges and Hopes for Vaccine Development and Overcoming Antiretroviral Drug ResistanceDOI: 10.12659/MSM.944600
Med Sci Monit 2024; 30:e944600
In Press
07 Mar 2024 : Clinical Research
Knowledge of and Attitudes Toward Clinical Trials: A Questionnaire-Based Study of 179 Male Third- and Fourt...Med Sci Monit In Press; DOI: 10.12659/MSM.943468
08 Mar 2024 : Animal Research
Modification of Experimental Model of Necrotizing Enterocolitis (NEC) in Rat Pups by Single Exposure to Hyp...Med Sci Monit In Press; DOI: 10.12659/MSM.943443
18 Apr 2024 : Clinical Research
Comparative Analysis of Open and Closed Sphincterotomy for the Treatment of Chronic Anal Fissure: Safety an...Med Sci Monit In Press; DOI: 10.12659/MSM.944127
08 Mar 2024 : Laboratory Research
Evaluation of Retentive Strength of 50 Endodontically-Treated Single-Rooted Mandibular Second Premolars Res...Med Sci Monit In Press; DOI: 10.12659/MSM.944110
Most Viewed Current Articles
17 Jan 2024 : Review article
Vaccination Guidelines for Pregnant Women: Addressing COVID-19 and the Omicron VariantDOI :10.12659/MSM.942799
Med Sci Monit 2024; 30:e942799
14 Dec 2022 : Clinical Research
Prevalence and Variability of Allergen-Specific Immunoglobulin E in Patients with Elevated Tryptase LevelsDOI :10.12659/MSM.937990
Med Sci Monit 2022; 28:e937990
16 May 2023 : Clinical Research
Electrophysiological Testing for an Auditory Processing Disorder and Reading Performance in 54 School Stude...DOI :10.12659/MSM.940387
Med Sci Monit 2023; 29:e940387
01 Jan 2022 : Editorial
Editorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Pa...DOI :10.12659/MSM.935952
Med Sci Monit 2022; 28:e935952