eISSN: 1643-3750


Get your full text copy in PDF

Apolipoproteins A-1 and B and the likelihood of non-fatal stroke and myocardial infarction -- data from The Third National Health and Nutrition Examination Survey.

Wayne H Giles, Janet B Croft, Adnan I Qureshi, Lee R Guterman, L Nelson Hopkins

Med Sci Monit 2002; 8(5): CR311-316

ID: 420844

BACKGROUND: The measurement of plasma apolipoproteins (APO) has been proposedfor predicting the risk of cardiovascular diseases. However, the association between APOs and strokeis not well defined. MATERIAL/METHODS: We evaluated the association between plasma concentrations ofAPO A-1 and APO B with a physician diagnosis of stroke (n=153), and electrocardiogram evidence or physiciandiagnosis of myocardial infarction (n=379), in a nationally representative sample of 3,696 US adultsaged >40 years who participated in the Third National Health and Nutrition Examination Survey. Multivariatelogistic regression analyses were used to investigate these relationships. RESULTS: After adjusting fordifferences in age, gender, race/ethnicity, education, hypertension, cholesterol, body mass index, andcigarette smoking, the upper quartile of APO A-1 (> or = 161 mg/dl) when compared with the lowest quartile( or = 1.59 when compared witha ratio < or = 1.04 was associated with a decreased likelihood of myocardial infarction (OR, 0.3; 95%CI, 0.2-0.6); and stroke (OR 0.4, 95% CI, 0.2-1.0). CONCLUSIONS: Higher APO A-1 concentrations were associatedwith a decreased likelihood for myocardial infarction but not for stroke. The APO A-1 to B ratio wasinversely associated with both myocardial infarction and stroke and may be an important protective clinicalmarker for atherosclerosis.

This paper has been published under Creative Common Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) allowing to download articles and share them with others as long as they credit the authors and the publisher, but without permission to change them in any way or use them commercially.
I agree