30 April 1999
Human pancreatic amylase and lipase serum levels in children and adolescents with chronic renal failure
Krzysztof Magier, Anna Wawro, Danuta ZwolinskaMed Sci Monit 1999; 5(3): CR495-498 :: ID: 504902
Abstract
Chronic renal failure (CRF) impairs homeostasis in many ways. Pancreas is one of the organs affected in the course of CRF. Gastrointestinal symptoms (nausea, abdominal pain, vomits) are often in CRF, but may be also caused by pancreatitis. The diagnosis of pancreatitis is more difficult in CRF patients because of the non-specific elevation of the serum activity of pancreatic enzymes observed during CRF. The aim of this study was to evaluate serum concentrations of human pancreatic amylase (h-p-A) and human pancreatic lipase (h-p-L) in CRF children and adolescents without clinical symptoms of pancreatitis treated conservatively and on chronic dialysis. The study was performed on 46 children and adolescents aged 1-26 yr. : 22 patients treated conservatively, aged 1-18 yr. (gr. I), 7 patients on continuous peritoneal dialysis, aged 2-18 yr. (gr. II) and 17 patients on hemodialysis aged 13-26 yr (gr. III). Control group consisted of 21 children aged 7-17 yr. Enzymes were assayed using immunoenzymatic test (ELISA). In all groups of children with CRF h-p-A and h-p-L values were significantly elevated comparing to the control group. There was no statistically significant differences between groups I, II and III, but the highest values both of enzymes was observed in children treated conservatively. In summary, the results show, that the non-specific elevation of serum h-p-A and h-p-L concentration occurs in CRF children and adolescents, and suggest that the usefulness of these enzymes for diagnostic of pancreatitis is limited.
Keywords: children, Lipase, amylase, chronic renal failure
Editorial
01 April 2024 : Editorial
Editorial: Forty Years of Waiting for Prevention and Cure of HIV Infection – Ongoing Challenges and Hopes for Vaccine Development and Overcoming Antiretroviral Drug ResistanceDOI: 10.12659/MSM.944600
Med Sci Monit 2024; 30:e944600
In Press
07 Mar 2024 : Clinical Research
Knowledge of and Attitudes Toward Clinical Trials: A Questionnaire-Based Study of 179 Male Third- and Fourt...Med Sci Monit In Press; DOI: 10.12659/MSM.943468
08 Mar 2024 : Animal Research
Modification of Experimental Model of Necrotizing Enterocolitis (NEC) in Rat Pups by Single Exposure to Hyp...Med Sci Monit In Press; DOI: 10.12659/MSM.943443
18 Apr 2024 : Clinical Research
Comparative Analysis of Open and Closed Sphincterotomy for the Treatment of Chronic Anal Fissure: Safety an...Med Sci Monit In Press; DOI: 10.12659/MSM.944127
08 Mar 2024 : Laboratory Research
Evaluation of Retentive Strength of 50 Endodontically-Treated Single-Rooted Mandibular Second Premolars Res...Med Sci Monit In Press; DOI: 10.12659/MSM.944110
Most Viewed Current Articles
17 Jan 2024 : Review article
Vaccination Guidelines for Pregnant Women: Addressing COVID-19 and the Omicron VariantDOI :10.12659/MSM.942799
Med Sci Monit 2024; 30:e942799
14 Dec 2022 : Clinical Research
Prevalence and Variability of Allergen-Specific Immunoglobulin E in Patients with Elevated Tryptase LevelsDOI :10.12659/MSM.937990
Med Sci Monit 2022; 28:e937990
16 May 2023 : Clinical Research
Electrophysiological Testing for an Auditory Processing Disorder and Reading Performance in 54 School Stude...DOI :10.12659/MSM.940387
Med Sci Monit 2023; 29:e940387
01 Jan 2022 : Editorial
Editorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Pa...DOI :10.12659/MSM.935952
Med Sci Monit 2022; 28:e935952