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22 May 2003

Absent end diastolic flow in umbilical artery and umbilical cord thrombosis at term of pregnancy

Giovanni Larciprete, Giuseppe di Pierro, Francesco Giacomello, Criselda Santacroce, Herbert Valensise, Domenico Arduini

Med Sci Monit 2003; 9(5): CS29-30 :: ID: 11080


Background: Meconium staining of the fetus and placenta is associated with increased neonatal mortality and asphyxia. Very often it is unclear whether the discharge of meconium is a cause or an
effect of fetal distress. In the available literature there are no large epidemiological studies of pregnancy outcome with meconium-related lesions, even though this could be useful to improve our state of knowledge on this topic.
Case Report: A case of umbilical cord vascular necrosis is described. A severely asphyxiated infant was delivered
at 39 weeks’ gestation by cesarean section due to alarming results of fetal heart rate monitoring and rupture of membranes with meconium-stained amniotic fluid. There was no meconium aspiration. We report a review of 15 similar cases. In the whole series, a linkage
between umbilical cord vascular necrosis and evidence of remote meconium discharge always seems to be detectable. The pathophysiological mechanism is unknown.
Conclusions: It is still not clear why only a tiny percentage of cases with meconium-stained amniotic fluid develops umbilical cord lesions and poor pregnancy outcome. Further investigations are
needed to explain why some meconium-stained newborns suffer severe neurological and other damage even without meconium aspiration.

Keywords: Diastole, Fetal Monitoring, Infant, Newborn, Meconium, Pregnancy, Thrombosis - etiology, Thrombosis - pathology, Thrombosis - physiopathology, Umbilical Arteries - pathology, Umbilical Arteries - physiopathology, Umbilical Veins - pathology, Umbilical Veins - physiopathology

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750