Logo Medical Science Monitor

Call: +1.631.470.9640
Closed: National Holiday

Contact Us

Logo Medical Science Monitor Logo Medical Science Monitor Logo Medical Science Monitor

01 March 2004

Reliability of the rapid bedside whole-blood quantitative cardiac troponin T assay in the diagnosis of myocardial injury in patients with acute coronary syndrome

Salam Saadeddin, Mohammed Habbab, Hisham Siddieg, Mahmoud Fayomi, Rofaida Dafterdar

Med Sci Monit 2004; 10(3): MT43-46 :: ID: 11602

Abstract

Background: A rapid bedside whole-blood quantitative cTnT assay has recently been developed. We evaluated
the reliability of this test for the diagnosis of myocardial injury in patients with acute coronary syndrome (ACS).
Material/Methods: Whole-blood cTnT levels were measured in 96 patients with ACS using the Roche Cardiac Reader[sup]®[/sup] rapid bedside assay device, and the results were compared with serum cTnT levels in the same patients measured by the Roche Elecsys[sup]®[/sup] Immunoanalyzer. There were 50 patients with clinical evidence of myocardial injury and 56 without.
Results: From the qualitative point of view (reporting negative or positive tests), the results of the rapid bedside tests were identical to those obtained by the serum immunoanalyzer. From
quantitative the point of view, the rapid bedside tests could not measure exact values below
0.1 ng/ml (reported negative) or above 2.0 ng/ml (reported >2.0). The measurements made by the rapid bedside tests within the range of 0.1 to 2.0 ng/ml correlated well with those of the serum immunoanalyzer (Cardiac Reader[sup]®[/sup] cTnT=0.61, Elecsys[sup]®[/sup] cTnT+0.12; r=0.88), but their mean values were significantly lower (1.20±0.71 vs. 1.41±1.03, p=0.0007).
Conclusions: The rapid bedside cTnT assay correlates well with immunoanalyzer measurements between
the values of 0.1 and 2.0 ng/ml. However, they tend to give significantly lower values and fail
to give exact values below 0.1 and above 2.0 ng/ml, which may affect their performance in monitoring and managing patients with ACS, and limit their use in predicting outcome.

Keywords: Coronary Arteriosclerosis - diagnosis, Dose-Response Relationship, Drug, Heart Diseases - diagnosis, Heart Injuries - diagnosis, Immunoassay - instrumentation, Immunoassay - methods, Myocardium - metabolism, Reagent Kits, Diagnostic, Reproducibility of Results, Sensitivity and Specificity, Troponin I - blood, Troponin T - blood, Coronary Artery Disease - diagnosis, Dose-Response Relationship, Drug, Heart Diseases - diagnosis, Heart Injuries - diagnosis, Immunoassay - methods, Myocardium - metabolism, Reagent Kits, Diagnostic, Reproducibility of Results, Sensitivity and Specificity, Troponin I - blood, Troponin T - blood

Add Comment 0 Comments

Editorial

01 February 2025 : Editorial  

Editorial: Current Approaches to Screening for Lung Cancer in Smokers and Non-Smokers

Dinah V. Parums

DOI: 10.12659/MSM.948255

Med Sci Monit 2025; 31:e948255

0:00

In Press

Review article  

Hydrogels in Oral Disease Management: A Review of Innovations in Drug Delivery and Tissue Regeneration

Med Sci Monit In Press; DOI: 10.12659/MSM.946122  

Clinical Research  

Procedure Dynamics in Transfemoral vs Transradial Cerebral Angiography: A Retrospective Study

Med Sci Monit In Press; DOI: 10.12659/MSM.947603  

Clinical Research  

Predicting Cerebral Small Vessel Disease Burden Based on Thromboelastography in Patients with Acute Ischemi...

Med Sci Monit In Press; DOI: 10.12659/MSM.946303  

Clinical Research  

Long-Term Outcomes of Implanon in Managing Adenomyosis: A 3-Year Prospective Study

Med Sci Monit In Press; DOI: 10.12659/MSM.945972  

Most Viewed Current Articles

17 Jan 2024 : Review article   6,969,459

Vaccination Guidelines for Pregnant Women: Addressing COVID-19 and the Omicron Variant

DOI :10.12659/MSM.942799

Med Sci Monit 2024; 30:e942799

0:00

16 May 2023 : Clinical Research   701,879

Electrophysiological Testing for an Auditory Processing Disorder and Reading Performance in 54 School Stude...

DOI :10.12659/MSM.940387

Med Sci Monit 2023; 29:e940387

0:00

01 Mar 2024 : Editorial   25,628

Editorial: First Regulatory Approvals for CRISPR-Cas9 Therapeutic Gene Editing for Sickle Cell Disease and ...

DOI :10.12659/MSM.944204

Med Sci Monit 2024; 30:e944204

0:00

28 Jan 2024 : Review article   20,173

A Review of IgA Vasculitis (Henoch-Schönlein Purpura) Past, Present, and Future

DOI :10.12659/MSM.943912

Med Sci Monit 2024; 30:e943912

0:00

Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750