Logo Medical Science Monitor

Call: +1.631.470.9640
Mon - Fri 10:00 am - 02:00 pm EST

Contact Us

Logo Medical Science Monitor Logo Medical Science Monitor Logo Medical Science Monitor

02 July 2004

Candida albicans switch phenotpes display differential levels of fitness

Kaaren G. Vargas, Rupasree Srikantha, Anamika Holke, Tamim Sifri, Ryan Morris, Sophie Joly

Med Sci Monit 2004; 10(7): BR198-206 :: ID: 11716

Abstract

Background:Candidiasis is a significant cause of morbidity and mortality in immunosuppressed individuals. Currently, there are limited treatment options for this opportunistic infection and there have been many reports in the literature of increased resistance to treatment. There is evidence to suggest that phenotypic switching of Candida albicans may play a role in this resistance. It was therefore, the purpose of this study to assess the variability among C. albicans switch phenotypes isolated from a single strain.
Material/Methods:Four switch phenotypes from a single strain of Candida albicans isolated from an HIV+ individual were evaluated for growth rates, post-antifungal effects in the presence of fluconazole, fluconazole uptake and morphological changes after fluconazole exposure.
Results:We found that, overall, smooth white and very wrinkled grew significantly faster then either ring or heavily myceliated and were most drastically affected by 4X and 6X MIC concentrations of fluconazole over a 24 hour period. When all four phenotypes were exposed to 64.
Conclusions:These results suggest that switch phenotypes from Candida albicans serve different roles in providing adaptability and survivability under differing conditions.

Keywords: Antifungal Agents - pharmacology, Blotting, Southern, Candida albicans - drug effects, Candida albicans - genetics, Candida albicans - growth & development, Candida albicans - physiology, Candidiasis - drug therapy, Candidiasis - metabolism, Candidiasis - microbiology, Drug Resistance, Fungal - drug effects, Drug Resistance, Fungal - genetics, Fluconazole - metabolism, Fluconazole - pharmacology, HIV Infections - microbiology, Phenotype, Time Factors, Tritium, Antifungal Agents - pharmacology, Blotting, Southern, Candida albicans - physiology, Candidiasis - microbiology, Drug Resistance, Fungal - genetics, Fluconazole - pharmacology, HIV Infections - microbiology, Phenotype, Time Factors, Tritium

Add Comment 0 Comments

Editorial

01 November 2024 : Editorial  

Editorial: Artificial Intelligence (AI), Digital Image Analysis, and the Future of Cancer Diagnosis and Prognosis

Dinah V. Parums

DOI: 10.12659/MSM.947038

Med Sci Monit 2024; 30:e947038

0:00

In Press

Review article  

Comprehensive Insights into Arecoline Hydrobromide: Pharmacology, Toxicity, and Pharmacokinetics

Med Sci Monit In Press; DOI: 10.12659/MSM.945582  

Clinical Research  

Iliac Periosteal Bone Autografting vs Talus Non-Weight-Bearing Surgery in Hepple V Talus Osteochondral Inju...

Med Sci Monit In Press; DOI: 10.12659/MSM.944912  

Clinical Research  

Impact of Different Orthodontic Appliances on Mandibular Condyle, Anterior Region of Mandibular, and Maxill...

Med Sci Monit In Press; DOI: 10.12659/MSM.946265  

Clinical Research  

Risk Factors for Bone Cement Displacement After Percutaneous Kyphoplasty in Osteoporotic Vertebral Fracture...

Med Sci Monit In Press; DOI: 10.12659/MSM.945884  

Most Viewed Current Articles

17 Jan 2024 : Review article   6,371,831

Vaccination Guidelines for Pregnant Women: Addressing COVID-19 and the Omicron Variant

DOI :10.12659/MSM.942799

Med Sci Monit 2024; 30:e942799

0:00

14 Dec 2022 : Clinical Research   1,909,013

Prevalence and Variability of Allergen-Specific Immunoglobulin E in Patients with Elevated Tryptase Levels

DOI :10.12659/MSM.937990

Med Sci Monit 2022; 28:e937990

0:00

16 May 2023 : Clinical Research   695,468

Electrophysiological Testing for an Auditory Processing Disorder and Reading Performance in 54 School Stude...

DOI :10.12659/MSM.940387

Med Sci Monit 2023; 29:e940387

0:00

07 Jan 2022 : Meta-Analysis   260,595

Efficacy and Safety of Light Therapy as a Home Treatment for Motor and Non-Motor Symptoms of Parkinson Dise...

DOI :10.12659/MSM.935074

Med Sci Monit 2022; 28:e935074

Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750