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25 June 2003

Decreased antioxidant activity in hypercholesterolemic children with nephrotic syndrome

Jacek Zachwieja, Waldemar Bobkowski, Agnieszka Dobrowolska-Zachwieja, Marcin Zaniew, Janusz Maciejewski

Med Sci Monit 2003; 9(6): CR235-239 :: ID: 12741


Background:The aim of the present study was to estimate the total antioxidant status (TAS) and main antioxidant enzyme activity in children with nephrotic syndrome (NS).Material/Methods:The study was carried out in a group of 82 children with NS, age 4–16 years (mean 7.4). Of these, 59 with a first episode formed group I, and 23 children in remission (>6 months, with no immunosuppressive treatment) formed group II. TAS was estimated using the two-reagent Randox Total Antioxidant Status test in plasma.Results:TAS was significantly reduced in group I compared to controls (0.77±0.14 mmol/l vs. 1.18±0.42 mmol/l; p

Keywords: Adolescent, Antioxidants - metabolism, Blood Proteins - metabolism, Child, Child, Preschool, Cholesterol - blood, Glutathione Peroxidase - blood, Glutathione Reductase - blood, Hypercholesterolemia - blood, Hypercholesterolemia - complications, Lipoproteins - blood, Nephrotic Syndrome - blood, Nephrotic Syndrome - complications, Recurrence, Reference Values, Superoxide Dismutase - blood, Triglycerides - blood

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750