Logo Medical Science Monitor

Call: +1.631.470.9640
Mon - Fri 10:00 am - 02:00 pm EST

Contact Us

Logo Medical Science Monitor Logo Medical Science Monitor Logo Medical Science Monitor

09 September 2002

Ischemic preconditioning diminishes oxygen demand and increases coronary flow in the early phase of reperfusion in rat heart

Tomasz Rudziński, Michał Mussur, Marcin Wawrzycki, Zbigniew Gwiazda, Janusz Zasłonka, Mirosław Mussur

Med Sci Monit 2002; 8(9): BR362-368 :: ID: 13263

Abstract

SUMMARY
Background: Ischemic preconditioning (IPC) can be defined as an adaptive mechanism induced by a brief period of reversible ischemia increasing the heart’s resistance to a subsequent longer period of
ischemia. The objective of our research was to describe the effects of IPC on the hemodynamic function and metabolism of the myocardium during postischemic reperfusion.
Material/Methods: 20 rat hearts were assigned to a preconditioning group (n=10) or to a control group (n=10). Preconditioning was achieved with 5 min. of global ischemia and 10 min. of reperfusion followed by 40 min. of ischemia. We investigated the postischemic recovery of aortic pressure, cardiac output, and coronary flow, as well as oxygen consumption, carbon dioxide release, and [H+] release.
Results: No significant intergroup differences in aortic pressure and cardiac output were observed during reperfusion. In both groups, increased coronary flow (greater in the IPC group: 11.4±0.6 ml/min. vs 9.1±0.5 ml/min. in control group) was observed in the early phase of reperfusion. This was accompanied by a rise in CO2 and [H+] release, which was also greater in the IPC group. Oxygen consumption was significantly lower in the IPC group in the later
phase of reperfusion (9.39±0.53 vs 11.79±0.54 µmol/min/g dry weight), as were CO2 and [H+] release.
Conclusions: IPC diminishes oxygen demand during reperfusion without changing the hemodynamic function considerably. IPC results in a transient increase of coronary flow accompanied by a rise in CO2 and [H+] release.

Keywords: Blood Flow Velocity, Carbon Dioxide - metabolism, Heart - physiology, Hydrogen - metabolism, Ions, Ischemic Preconditioning, Oxygen - metabolism, Oxygen Consumption, Perfusion, Rats, Wistar, Reperfusion, Time Factors

Add Comment 0 Comments

659 1

Editorial

01 June 2023 : Editorial  

Editorial: Infectious Disease Surveillance Using Artificial Intelligence (AI) and its Role in Epidemic and Pandemic Preparedness

Dinah V. Parums
Science Editor, Medical Science Monitor, International Scientific Information, Inc., Melville, NY, USA

DOI: 10.12659/MSM.941209

Med Sci Monit 2023; 29:e941209

0:00

In Press

07 Jun 2023 : Review article  

Ultrasound-Guided Brachial Plexus Block by Costoclavicular Space Approach: A Narrative Review

Med Sci Monit In Press; DOI: 10.12659/MSM.939920  

05 Jun 2023 : Clinical Research  

Comparison of Texture and Color Enhancement Imaging with White Light Imaging in 52 Patients with Short-Segm...

Med Sci Monit In Press; DOI: 10.12659/MSM.940249  

05 Jun 2023 : Laboratory Research  

Comparison of Composite Resin (Duo-Shade) Shade Guide with Vita Ceramic Shades Before and After Chemical an...

Med Sci Monit In Press; DOI: 10.12659/MSM.940949  

02 Jun 2023 : Database Analysis  

The COVID-19 Crisis and the Incidence of Alcohol-Related Deaths in Poland

Med Sci Monit In Press; DOI: 10.12659/MSM.940904  

Most Viewed Current Articles

13 Nov 2021 : Clinical Research  

Acceptance of COVID-19 Vaccination and Its Associated Factors Among Cancer Patients Attending the Oncology ...

DOI :10.12659/MSM.932788

Med Sci Monit 2021; 27:e932788

0:00

30 Dec 2021 : Clinical Research  

Retrospective Study of Outcomes and Hospitalization Rates of Patients in Italy with a Confirmed Diagnosis o...

DOI :10.12659/MSM.935379

Med Sci Monit 2021; 27:e935379

08 Mar 2022 : Review article  

A Review of the Potential Roles of Antioxidant and Anti-Inflammatory Pharmacological Approaches for the Man...

DOI :10.12659/MSM.936292

Med Sci Monit 2022; 28:e936292

01 Jan 2022 : Editorial  

Editorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Pa...

DOI :10.12659/MSM.935952

Med Sci Monit 2022; 28:e935952

Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750