Logo Medical Science Monitor

Call: +1.631.470.9640
Mon - Fri 10:00 am - 02:00 pm EST

Contact Us

Logo Medical Science Monitor Logo Medical Science Monitor Logo Medical Science Monitor

03 November 2003

The use of corticosteroids versus other treatments for Graves’ ophthalmopathy: A quantitative evaluation

Sheikha Abalkhail, Suhail A.R. Doi, Kamal A.S. Al-Shoumer

Med Sci Monit 2003; 9(11): CR477-483 :: ID: 13371

Abstract

Background:The purpose of the present study was to evaluate the efficacy of corticosteroids in the treatment of Graves’ ophthalmopathy in comparison to other treatment modalities.Material/Methods:15 studies were identified but only 14 were included in the final analysis, 5 cohort and 9 randomized. A total of 813 patients were included in this quantitative review.Results:The relative risk with oral corticosteroid treatment (OCS) alone vs. other treatment could not be pooled, as the studies were heterogeneous and the RR was dependent on risk of failure in the control group. In the two studies that reported head-on comparison between OCS and radiotherapy, no clinically significant difference was found. However, the combination of OCS and radiotherapy was markedly more effective than either modality alone (pooled RRR 70%). The number of patients who should be treated with the combination of CS and radiotherapy to prevent one more failure was between 3 to 8. Evidence from the studies suggest that intravenous corticosteroid's IVCSs used alone have similar or greater efficacy than the combination.Conclusions:Corticosteroids seem to be an effective treatment for Graves’ ophthalmopathy compared to other treatments currently available. Oral corticosteroids appear to have increased effect when given with radiotherapy. IVCSs, with or without radiotherapy, seem to have the best documented efficacy. Side effects can also be overcome by the use of IVCS pulse therapy (without OCS), which needs to be pursued in further, separate research as an alternative to oral therapy, since it could be both more effective and safer.

Keywords: Administration, Oral, Adrenal Cortex Hormones - therapeutic use, Cohort Studies, Graves Disease - drug therapy, Graves Disease - radiotherapy, Radiotherapy, Random Allocation, Risk, Risk Factors

Add Comment 0 Comments

Editorial

01 June 2024 : Editorial  

Editorial: Concerns as Highly Pathogenic Avian Influenza (HPAI) Virus of the H5N1 Subtype is Identified in Dairy Cows and Other Mammals

Dinah V. Parums

DOI: 10.12659/MSM.945315

Med Sci Monit 2024; 30:e945315

0:00

In Press

Clinical Research  

Comparative Evaluation of Digital Cephalometric Tracing Applications on Mobile Devices and Manual Tracing

Med Sci Monit In Press; DOI: 10.12659/MSM.944628  

0:00

Clinical Research  

Impact of COVID-19-Induced Academic Stress on Insomnia and Suicidal Ideation among Taiwanese Health Trainee...

Med Sci Monit In Press; DOI: 10.12659/MSM.944932  

Review article  

Impact of Workplace Bullying on Nursing Care Quality: A Comprehensive Review

Med Sci Monit In Press; DOI: 10.12659/MSM.944815  

Clinical Research  

Anterior Plate-Supported Cannulated Screw Surgery for Ankle Arthrodesis: Clinical and Radiologic Results in...

Med Sci Monit In Press; DOI: 10.12659/MSM.944452  

Most Viewed Current Articles

17 Jan 2024 : Review article   1,882,405

Vaccination Guidelines for Pregnant Women: Addressing COVID-19 and the Omicron Variant

DOI :10.12659/MSM.942799

Med Sci Monit 2024; 30:e942799

0:00

14 Dec 2022 : Clinical Research   1,538,203

Prevalence and Variability of Allergen-Specific Immunoglobulin E in Patients with Elevated Tryptase Levels

DOI :10.12659/MSM.937990

Med Sci Monit 2022; 28:e937990

0:00

16 May 2023 : Clinical Research   690,402

Electrophysiological Testing for an Auditory Processing Disorder and Reading Performance in 54 School Stude...

DOI :10.12659/MSM.940387

Med Sci Monit 2023; 29:e940387

0:00

01 Jan 2022 : Editorial   50,329

Editorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Pa...

DOI :10.12659/MSM.935952

Med Sci Monit 2022; 28:e935952

0:00

Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750