09 September 2002
Influence of the hepatocellular damage on the clinical usefulness of biochemical markers of bone metabolism and parathormon in haemodialysed patientsAndrzej J. Jaroszyński, Andrzej Książek, Wojciech Załuska
Med Sci Monit 2002; 8(9): CR652-656 :: ID: 13490
Background: The present study was undertaken to determine if hepatitis C virus (HCV) and cytomegalovirus (CMV) infections, as well as biochemical indices of liver damage, can significantly influence the relationships occurring between markers of bone formation, resorption
and PTH in hemodialysis patients.
Material/Methods: 76 HD patients were tested for anti-HCV and anti-CMV antibodies. Serum intact PTH osteocalcin, total and bone isoenzyme of alkaline phosphatase, and plasma tartrate-resistant acid
phosphatase were determined as bone metabolism indices. Serum alanine aminotransferase (ALT) and gamma-glutamyl transferase (γ-GT) were measured as markers of hepatocyte function.
The patients were divided into subgroups according to serological and enzymatic status.
Results: 37 patients were anti-HCV positive, 61 were anti-CMV positive, and 35 were both anti-HCV and anti-CMV positive. 13 patients were free of viruses. Elevated ALT and γ-GT activity was
found in 26 and 15 patients respectively. Indices of bone formation, resorption and PTH values showed no significance differences in the respective subgroups. Markers of bone formation significantly correlated with one another, as well as markers of bone resorption and intact PTH in all patients. In the subgroup of patients with increased γ-GT activity, significant differences were found in the slopes of the regression lines occurring in most of the estimated correlations
in comparison with all other subgroups.
Conclusions: In renal osteodystrophy, hepatocellular damage indicated by an increase of γ-GT influences the relationship between the biochemical markers of bone metabolism and parathormon levels,
but the presence of anti-HCV and anti-CMV antibodies does not.
Keywords: Hepatitis C - metabolism
01 November 2023 : EditorialEditorial: Factors Driving New Variants of SARS-CoV-2, Immune Escape, and Resistance to Antiviral Treatments as the End of the COVID-19 Pandemic is Declared
Med Sci Monit 2023; 29:e942960
29 Nov 2023 : Laboratory ResearchCTRP13 Mitigates Endothelial Cell Ferroptosis via the AMPK/KLF4 Pathway: Implications for Atherosclerosis P...
Med Sci Monit In Press; DOI: 10.12659/MSM.942733
28 Nov 2023 : Clinical ResearchImpact of Fluorodeoxyglucose-Positron Emission Tomography/Computed Tomography on Therapeutic Decisions and ...
Med Sci Monit In Press; DOI: 10.12659/MSM.942122
28 Nov 2023 : Clinical ResearchLong-Term Outcomes of Decompression and Grafting in Acute Pathological Proximal Femur Fractures in Children...
Med Sci Monit In Press; DOI: 10.12659/MSM.943031
Most Viewed Current Articles
13 Nov 2021 : Clinical ResearchAcceptance of COVID-19 Vaccination and Its Associated Factors Among Cancer Patients Attending the Oncology ...
Med Sci Monit 2021; 27:e932788
30 Dec 2021 : Clinical ResearchRetrospective Study of Outcomes and Hospitalization Rates of Patients in Italy with a Confirmed Diagnosis o...
Med Sci Monit 2021; 27:e935379
14 Dec 2022 : Clinical ResearchPrevalence and Variability of Allergen-Specific Immunoglobulin E in Patients with Elevated Tryptase Levels
Med Sci Monit 2022; 28:e937990
08 Mar 2022 : Review articleA Review of the Potential Roles of Antioxidant and Anti-Inflammatory Pharmacological Approaches for the Man...
Med Sci Monit 2022; 28:e936292