Logo Medical Science Monitor

Call: +1.631.470.9640
Mon - Fri 10:00 am - 02:00 pm EST

Contact Us

Logo Medical Science Monitor Logo Medical Science Monitor Logo Medical Science Monitor

02 May 2003

PARP-inhibitors for ischemia-reperfusion injury of the liver

H. Mota-Filipe

Med Sci Monit 2003; 9(1): 46- :: ID: 15109

Abstract

Ischemia-reperfusion (I/R) is responsible for the development of liver dysfunction and failure in several clinical conditions including liver transplantation and hemorrhagic shock. At the present, there is no pharmacological intervention proven to either attenuate liver cell injury or to augment tissue regeneration of the liver after acute or chronic injury of this organ. The occurrence of oxidant-mediated damage resulting from I/R has been demonstrated in several different animal models [1,2], where the generation of reactive oxygen species contributes to DNA damage [3]. One possible way of oxidant-induced injury involves the excessive activation of the nuclear enzyme poly-(ADP-ribose) polymerase (PARP).Using a rat model of liver I/R, we have the effects of the water-soluble PARP-inhibitor 5-aminoisoquinoline (5-AIQ) on liver injury (transaminases, histopathology), the upregulation of the adhesion molecule intracellular adhesion molecule 1 (ICAM-1) and the increase in PARP activity (measured as immunoreactivity of PAR), and the degree of lipid peroxidation caused by ischaemia and reperfusion (I/R) of the liver. When compared to control, 5-AIQ reduced the I/R-induced rise in the serum levels of transaminases, lactate dehydrogenase, and g-glutamyl transferase as well as the degree of lipid peroxidation. Liver sections obtained from 5-AIQ treated rats showed reduced PARP activation and less staining for ICAM-1. The role that PARP plays in the process of recovery that follows I/R injury to the liver will be discussed. References: 1.Caldwell-Kendel JC, Currin RT, Tanaka Y et al: Reperfusion injury to endothelial cells following cold ischemic storage of rat livers. Hepatology, 1989; 10: 92-9 2.Schoenberg MH, Muhl E, Sellin D et al: Posthypotensive generation of superoxide free-radicals – possible role in the pathogenesis of the intestinal mucosal damage. Acta Chir Scand, 1984; 150: 301-9 3.Martin D, Lewington A, Hammerman M, Padanilam B: Inhibition of poly (ADP-ribose) polymerase attenuates ischemic renal injury in rats. Am J Physiol Regulatiry Integrative Comp Physiol, 2000; 279: 1834-40

Keywords: Liver, ischemia-reperfusion, PARP, 5-aminoisoquinoline

0 Comments

Editorial

01 March 2023 : Editorial  

Editorial: Global Surveillance of Highly Pathogenic Avian Influenza Viruses in Poultry, Wild Birds, and Mammals to Prevent a Human Influenza Pandemic

Dinah V. Parums
Science Editor, Medical Science Monitor, International Scientific Information, Inc., Melville, NY, USA

DOI: 10.12659/MSM.939968

Med Sci Monit 2023; 29:e939968

SARS-CoV-2/COVID-19

29 March 2023 : Editorial  

Editorial: Effective Direct-Acting Antiviral Treatments Support Global and National Programs to Eliminate H...

Med Sci Monit In Press; DOI: 10.12659/MSM.940519  

30 March 2023 : Clinical Research  

An Online Survey on the Relationship Between Positive Coping and Post-Traumatic Stress Symptoms (PTSS) of M...

Med Sci Monit In Press; DOI: 10.12659/MSM.939485  

09 February 2023 : Clinical Research  

Evaluation of Health-Related Quality of Life and Mental Health in 729 Medical Students in Indonesia During ...

Med Sci Monit 2023; 29:e938892

In Press

30 Mar 2023 : Clinical Research  

An Online Survey on the Relationship Between Positive Coping and Post-Traumatic Stress Symptoms (PTSS) of M...

Med Sci Monit In Press; DOI: 10.12659/MSM.939485  

30 Mar 2023 : Database Analysis  

Global Research Trends and Hotspots in Lateral Epicondylitis During the Past 30 Years: A Bibliometric and V...

Med Sci Monit In Press; DOI: 10.12659/MSM.939309  

29 Mar 2023 : Editorial  

Editorial: Effective Direct-Acting Antiviral Treatments Support Global and National Programs to Eliminate H...

Med Sci Monit In Press; DOI: 10.12659/MSM.940519  

29 Mar 2023 : Laboratory Research  

Preparation, Physicochemical Properties, and Structural Characterization of Resistant Starch-Aspirin-Loaded...

Med Sci Monit In Press; DOI: 10.12659/MSM.939711  

Most Viewed Current Articles

13 Nov 2021 : Clinical Research  

Acceptance of COVID-19 Vaccination and Its Associated Factors Among Cancer Patients Attending the Oncology ...

DOI :10.12659/MSM.932788

Med Sci Monit 2021; 27:e932788

30 Dec 2021 : Clinical Research  

Retrospective Study of Outcomes and Hospitalization Rates of Patients in Italy with a Confirmed Diagnosis o...

DOI :10.12659/MSM.935379

Med Sci Monit 2021; 27:e935379

08 Mar 2022 : Review article  

A Review of the Potential Roles of Antioxidant and Anti-Inflammatory Pharmacological Approaches for the Man...

DOI :10.12659/MSM.936292

Med Sci Monit 2022; 28:e936292

01 Jan 2022 : Editorial  

Editorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Pa...

DOI :10.12659/MSM.935952

Med Sci Monit 2022; 28:e935952

Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750