Logo Medical Science Monitor

Call: +1.631.470.9640
Mon - Fri 10:00 am - 02:00 pm EST

Contact Us

Logo Medical Science Monitor Logo Medical Science Monitor Logo Medical Science Monitor

20 May 2003 : Original article  

Albumin dialysis (MARS)as a new supportive treatment in patients with hepatic encephalopathy

J. Rubik, S. Prokurat, J. Pawłowska, R. Grenda, P. Kaliciński, M. Migdał, A. Kamiński

Med Sci Monit 2003; 9(2): 77-81 :: ID: 15327


Hepatic encephalopathy (HE)may occur in patients with acute and decompensated chronic liver failure.One of the pathogenetic mechanisms is accumulation of ‘liver ’toxins such as ammonia in astrocytes causing brain oedema.In cases of acute liver failure deterioration of patient ’s condition to coma may be rapid and outcome poor.Multiple attempts have been made to reduce mortality of patients with HE.Urgent liver transplantation is considered as treatment of choice in most patients.Many therapies have been used to remove ‘liver ’toxins from circulation:dialysis, hemoperfusion, plasmapheresis, extracorporeal liver perfusion and others.None of them remained in routine clinical practice.Recently a new cell-free method designed for the selective removal of albumin-bound substances normally cleared by the liver (MARS –Molecular Adsorbent Recirculating System) is available. We have been using this method in Children ’s Memorial Health Institute since July 2001 to support vital functions in some patients listed for liver transplantation.Till now we have performed 11 sessions in 7 patients with acute liver failure and hepatic encephalopathy.Four patients survived (one recovered without liver transplantation and three were transplanted) and three patients died (two before organ for transplantation was available and one during surgical procedure).We have obtained decrease of serum toxins concentration (ammonia, bilirubine, creatinine and others) and clinical improvement. In our opinion albumin dialysis MARS is promising new method of detoxification in critically ill patients with liver dysfunction.

Keywords: hepatic encephalopathy, albumin dialysis, Mars

Add Comment 0 Comments


01 February 2024 : Editorial  

Editorial: Global Health Concerns as Vaccine-Preventable Infections Including SARS-CoV-2 (JN.1), Influenza, Respiratory Syncytial Virus (RSV), and Measles Continue to Rise

Dinah V. Parums

DOI: 10.12659/MSM.943911

Med Sci Monit 2024; 30:e943911


In Press

28 Dec 2023 : Clinical Research  

Prognostic Assessment of Colorectal Cancer Patients after Laparoscopic Surgery: A Comprehensive Evaluation ...

Med Sci Monit In Press; DOI: 10.12659/MSM.942658  


05 Jan 2024 : Clinical Research  

Effectiveness of Glutamine Oral Care in Reducing Oral Mucositis and Improving Oral Health After Neurosurger...

Med Sci Monit In Press; DOI: 10.12659/MSM.942585  

02 Jan 2024 : Clinical Research  

Urinary Concentration of Renal Biomarkers in Healthy Term Neonates: Gender Differences in GST-pi Excretion

Med Sci Monit In Press; DOI: 10.12659/MSM.942819  

29 Dec 2023 : Clinical Research  

Performance of Subcutaneous Implantable Cardioverter Defibrillator (S-ICD) in Chinese Population with Prima...

Med Sci Monit In Press; DOI: 10.12659/MSM.942747  

Most Viewed Current Articles

16 May 2023 : Clinical Research  

Electrophysiological Testing for an Auditory Processing Disorder and Reading Performance in 54 School Stude...

DOI :10.12659/MSM.940387

Med Sci Monit 2023; 29:e940387


17 Jan 2024 : Review article  

Vaccination Guidelines for Pregnant Women: Addressing COVID-19 and the Omicron Variant

DOI :10.12659/MSM.942799

Med Sci Monit 2024; 30:e942799


14 Dec 2022 : Clinical Research  

Prevalence and Variability of Allergen-Specific Immunoglobulin E in Patients with Elevated Tryptase Levels

DOI :10.12659/MSM.937990

Med Sci Monit 2022; 28:e937990


01 Jan 2022 : Editorial  

Editorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Pa...

DOI :10.12659/MSM.935952

Med Sci Monit 2022; 28:e935952


Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750