Logo Medical Science Monitor

Call: +1.631.470.9640
Mon - Fri 10:00 am - 02:00 pm EST

Contact Us

Logo Medical Science Monitor Logo Medical Science Monitor Logo Medical Science Monitor

01 June 2005 : Original article  

The effects of type 2 diabetes and aging on vascular endothelial and autonomic function

Jerrold Petrofsky, Scott Lee

Med Sci Monit 2005; 11(6): CR247-254 :: ID: 16497

Abstract

Summary
Background: Both endothelial cell function and autonomic function are infl uenced by age. However, the interrelationships between the 2 have not been carefully examined. Material and Methods: Thirty nondiabetic control subjects (C) and 25 subjects with type 2 diabetes (D) participated. Endothelial cell function was assessed by 4 minutes of occlusion of the brachial artery followed by measurement of blood
fl ow (BF) immediately post occlusion. To assess autonomic reactivity, subjects were exposed to a 32oC room for 30 minutes and a tilt table elevated subjects from the horizontal to the 45 degree head up
position. A laser Doppler fl ow imager was used to assess skin fl ows during the tilting phase.
Results: For endothelial function, the average BF of C increased 2.24±0.64 cc/100 gm tissue/minute at rest to 26.8±4.9 cc/100 gm tissue per minute post occlusion. D subjects had resting BF of 0.8 cc/100 gm tissue per minute with an increase to an average of 8.1±3.64 cc/100gm tissue per minute post occlusion. In both, aging was associated with lower resting and post occlusion BF. However, D had lower BF than the controls. For D, both the resting fl ows and reduction in fl ows during tilting were less than the controls. Both groups followed a parallel decrease in fl ow with aging. Autonomic reactivity (ratio of BF to the skin in the vertical to horizontal posture) was 0.4±0.27 for the controls and 0.72±0.09 for the subjects with diabetes.
Conclusions: The data suggests that diabetes alters both the endothelial and autonomic function.

Keywords: Diabetes Mellitus, Type 2 - immunology, Aging - physiology, Autoimmunity, Blood Flow Velocity, Blood Pressure, Diabetes Mellitus, Type 2 - physiopathology, Endothelium, Vascular - physiopathology, Forearm - physiopathology, Posture, Reference Values, Regression Analysis, Skin - blood supply

Add Comment 0 Comments

Editorial

01 November 2024 : Editorial  

Editorial: Artificial Intelligence (AI), Digital Image Analysis, and the Future of Cancer Diagnosis and Prognosis

Dinah V. Parums

DOI: 10.12659/MSM.947038

Med Sci Monit 2024; 30:e947038

0:00

In Press

Review article  

Comprehensive Insights into Arecoline Hydrobromide: Pharmacology, Toxicity, and Pharmacokinetics

Med Sci Monit In Press; DOI: 10.12659/MSM.945582  

Clinical Research  

Iliac Periosteal Bone Autografting vs Talus Non-Weight-Bearing Surgery in Hepple V Talus Osteochondral Inju...

Med Sci Monit In Press; DOI: 10.12659/MSM.944912  

Clinical Research  

Impact of Different Orthodontic Appliances on Mandibular Condyle, Anterior Region of Mandibular, and Maxill...

Med Sci Monit In Press; DOI: 10.12659/MSM.946265  

Clinical Research  

Risk Factors for Bone Cement Displacement After Percutaneous Kyphoplasty in Osteoporotic Vertebral Fracture...

Med Sci Monit In Press; DOI: 10.12659/MSM.945884  

Most Viewed Current Articles

17 Jan 2024 : Review article   6,371,831

Vaccination Guidelines for Pregnant Women: Addressing COVID-19 and the Omicron Variant

DOI :10.12659/MSM.942799

Med Sci Monit 2024; 30:e942799

0:00

14 Dec 2022 : Clinical Research   1,909,013

Prevalence and Variability of Allergen-Specific Immunoglobulin E in Patients with Elevated Tryptase Levels

DOI :10.12659/MSM.937990

Med Sci Monit 2022; 28:e937990

0:00

16 May 2023 : Clinical Research   695,468

Electrophysiological Testing for an Auditory Processing Disorder and Reading Performance in 54 School Stude...

DOI :10.12659/MSM.940387

Med Sci Monit 2023; 29:e940387

0:00

07 Jan 2022 : Meta-Analysis   260,595

Efficacy and Safety of Light Therapy as a Home Treatment for Motor and Non-Motor Symptoms of Parkinson Dise...

DOI :10.12659/MSM.935074

Med Sci Monit 2022; 28:e935074

Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750