Logo Medical Science Monitor

Call: +1.631.470.9640
Mon - Fri 10:00 am - 02:00 pm EST

Contact Us

Logo Medical Science Monitor Logo Medical Science Monitor Logo Medical Science Monitor

01 June 2005 : Original article  

Lack of association between polymorphisms of dopamine receptors, type D2, and bipolar affective illness in a Polish population

Anna Leszczyńska-Rodziewicz, Joanna Hauser, Monika Dmitrzak-Węglarz, Maria Skibińska, Piotr Czerski, Marzena Zakrzewska, Magdalena Kosmowska, Janusz Rybakowski

Med Sci Monit 2005; 11(6): CR289-295 :: ID: 16506

Abstract

Summary
Background: Biochemical abnormalities are thought to be important factors causing bipolar disorder. Several lines of evidence suggest dopamine may play a role in its etiology, e.g. depressive syndrome is frequently encountered in subjects affected by Parkinson’s disease, where dopamine depletion is observed. Thus the genes of the dopaminergic system are good candidates for studies on bipolar
disorder. In the present study, we investigated polymorphisms of dopamine receptors, type D2, including the dopamine receptors D2, D3 and D4.
Material/Methods: Polish bipolar patients (n=339) and control subjects (n=366) were analyzed for three dopamine receptor gene polymorphisms: dopamine receptor D2 (DRD2) 141 ins/del, dopamine receptor D3 (DRD3) Ser9Gly, and dopamine receptor D4 (DRD4) 521 C/T.
Results: Allele and genotype frequencies did not differ signifi cantly among patients and controls. We did not obtain any signifi cant association between the studied polymorphisms and bipolar disorder.
Conclusions: The results suggests that the studied gene variants of type D2 dopamine receptors are not promising candidate genes for bipolar affective illness. We did not consider the family history of the examined subjects, and also the control group was not psychiatrically screened, which may contribute to the lack of signifi cant results.

Keywords: Adolescent, Bipolar Disorder - genetics, Genotype, Poland, Polymorphism, Genetic, Receptors, Dopamine D2 - genetics, Receptors, Dopamine D3, Receptors, Dopamine D4, Reference Values, Sequence Deletion, Variation (Genetics), Adolescent, Bipolar Disorder - genetics, genetic variation, Genotype, Poland, Polymorphism, Genetic, Receptors, Dopamine D2 - genetics, Receptors, Dopamine D3, Receptors, Dopamine D4, Reference Values, Sequence Deletion

Add Comment 0 Comments

Editorial

01 May 2024 : Editorial  

Editorial: First Regulatory Approval for Adoptive Cell Therapy with Autologous Tumor-Infiltrating Lymphocytes (TILs) – Lifileucel (Amtagvi)

Dinah V. Parums

DOI: 10.12659/MSM.944927

Med Sci Monit 2024; 30:e944927

In Press

17 Mar 2024 : Clinical Research  

Protective Role of TRPC3 Gene Polymorphism (rs10518289) in Obstructive Sleep Apnea Hypopnea Syndrome Among ...

Med Sci Monit In Press; DOI: 10.12659/MSM.942667  

0:00

27 Mar 2024 : Clinical Research  

Impact of Patient Education Formats on Treatment Adherence and Denture Hygiene in Edentulous Patients: A Co...

Med Sci Monit In Press; DOI: 10.12659/MSM.944175  

27 Mar 2024 : Clinical Research  

Incidence, Risk Factors, and Outcomes of Left Atrial Enlargement in Patients Requiring Right Ventricular Pa...

Med Sci Monit In Press; DOI: 10.12659/MSM.944114  

15 May 2024 : Database Analysis  

MRTO4 Enhances Glycolysis to Facilitate HCC Progression by Inhibiting ALDOB

Med Sci Monit In Press; DOI: 10.12659/MSM.944685  

Most Viewed Current Articles

17 Jan 2024 : Review article  

Vaccination Guidelines for Pregnant Women: Addressing COVID-19 and the Omicron Variant

DOI :10.12659/MSM.942799

Med Sci Monit 2024; 30:e942799

0:00

14 Dec 2022 : Clinical Research  

Prevalence and Variability of Allergen-Specific Immunoglobulin E in Patients with Elevated Tryptase Levels

DOI :10.12659/MSM.937990

Med Sci Monit 2022; 28:e937990

0:00

16 May 2023 : Clinical Research  

Electrophysiological Testing for an Auditory Processing Disorder and Reading Performance in 54 School Stude...

DOI :10.12659/MSM.940387

Med Sci Monit 2023; 29:e940387

0:00

01 Jan 2022 : Editorial  

Editorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Pa...

DOI :10.12659/MSM.935952

Med Sci Monit 2022; 28:e935952

0:00

Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750