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01 July 2005 : Extended abstract from EFAS 2011  

Effects of electrical stimulation on skin blood flow in controls and in andaround stage III and IV wounds in hairy and non hairy skin.

Jerrold Petrofsky, Ernie Schwab, Taiken Lo, Maria Cúneo, James George, Jina Kim, Abdul Al-Malty

Med Sci Monit 2005; 11(7): CR309-316 :: ID: 16979


Background: While wounds heal more quickly when electrical stimulation(ES) is applied, few studies have examined blood flow (BF) in and around wounds during ES in controlswith no wounds compared to wounds in diabetic and non diabetic subjects. Material/Methods: Ten subjectswith stage III and IV wounds and 8 controls were subjected to 5 minutes of biphasic ES (20 milliamps,pulse width 250 usec). Before, during, and after, BF were measured by a Laser Doppler Imager. Results:For the control subjects, in the fingers, BF increased from 307 flux to 687 after 5 min of ES to onefinger but BF also increased to other fingers indicating a reflex increase in flow mediated by the sympatheticnervous system. For hairy skin, there was a 12% increase in BF with ES and only in the line directlybetween the stimulating electrodes. For the patients (either with or without Type 2 diabetes), stimulationin the hand, leg and foot all caused a large increase in BF during and for 5 minutes after stimulation.In patients, BF was high in the wound area before ES and increased by 53% during, and remained high afterstimulation was over. Conclusions: The results show that in wounds, where BF is high due to bradykininand cytokine release, the vasoconstrictor tone is not present and electrical stimulation causes a largeincrease in circulation which lasts after stimulation is over.

Keywords: Diabetes Mellitus, Type 2 - complications, Diabetes Mellitus, Type 2 - complications, Electric Stimulation Therapy, Foot - blood supply, Hair, Hand - blood supply, Laser-Doppler Flowmetry, Regional Blood Flow, Skin - injuries, Wound Healing



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Ana Luisa Ordóñez-Vázquez, Sofía Murúa Beltrán-Gall, Shreya C. Pal, Nahum Méndez-Sánchez
Liver Research Unit, Medica Sur Clinic Foundation, Mexico City, Mexico

DOI: 10.12659/MSM.938365

Med Sci Monit 2022; 28:e938365


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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750