01 July 2005 : Review article
Adult neurogenesis in the mammalian central nervous system: functionality andpotential clinical interest.Philippe Taupin
Med Sci Monit 2005; 11(7): RA247-252 :: ID: 16988
In the past decades, much evidence has confirmed that neurogenesis occursin the adult brain and that neural stem cells reside in the adult central nervous system, overturningthe long-held dogma that we are born with a certain number of nerve cells and that the brain cannot generatenew neurons and renew itself. In the adult brain, neurogenesis occurs mainly in two areas: the hippocampusand the subventricular zone, and self-renewing, multipotent neural stem cells have been isolated andcharacterized in vitro from various regions of the adult central nervous system. Though significantadvances have been made in this field of research, the identification and function of neural stem cellsin the adult central nervous system remain the source of debate and controversy. Neurogenesis is modulatedby several normal and pathologic conditions, suggesting the involvement of the hippocampus and the subventricularzone in a broad range of functions, and that environmental stimuli and pathological conditions may havelong-term consequences on the architecture and functioning of the central nervous system. Neurogenesisis involved in processes such as learning, memory, and depression, and may also be involved in regenerativeattempts after injuries to the central nervous system. However, the contribution of neurogenesis to thesephenomena remains to be elucidated. Neural stem cells also hold the promise to cure a broad range ofneurological diseases and injuries. Cell therapeutic interventions may involve both cell transplantationand the stimulation of endogenous neural progenitor cells.
Keywords: Brain - cytology, Brain - physiology, Brain Diseases - pathology, Multipotent Stem Cells - cytology, Nerve Regeneration, Neurons - cytology, Brain - physiology, Brain Diseases - pathology, Multipotent Stem Cells - cytology, Nerve Regeneration, Neurons - cytology
01 June 2023 : EditorialEditorial: Infectious Disease Surveillance Using Artificial Intelligence (AI) and its Role in Epidemic and Pandemic Preparedness
Med Sci Monit 2023; 29:e941209
05 Jun 2023 : Laboratory ResearchComparison of Composite Resin (Duo-Shade) Shade Guide with Vita Ceramic Shades Before and After Chemical an...
Med Sci Monit In Press; DOI: 10.12659/MSM.940949
01 Jun 2023 : Clinical ResearchRoot Canal Numbers and Configurations in 1080 Permanent Canine Teeth in 270 Saudi Subjects Using Cone-Beam ...
Med Sci Monit In Press; DOI: 10.12659/MSM.940472
01 Jun 2023 : Clinical ResearchInternal Orifice Alloy Closure: A New Procedure for Treatment of Perianal Fistulizing Crohn’s Disease
Med Sci Monit In Press; DOI: 10.12659/MSM.940873
01 Jun 2023 : Clinical ResearchEffectiveness of Needle Aspiration versus Surgical Excision for Symptomatic Synovial Cysts of the Hip: A Si...
Med Sci Monit In Press; DOI: 10.12659/MSM.940187
Most Viewed Current Articles
13 Nov 2021 : Clinical ResearchAcceptance of COVID-19 Vaccination and Its Associated Factors Among Cancer Patients Attending the Oncology ...
Med Sci Monit 2021; 27:e932788
30 Dec 2021 : Clinical ResearchRetrospective Study of Outcomes and Hospitalization Rates of Patients in Italy with a Confirmed Diagnosis o...
Med Sci Monit 2021; 27:e935379
08 Mar 2022 : Review articleA Review of the Potential Roles of Antioxidant and Anti-Inflammatory Pharmacological Approaches for the Man...
Med Sci Monit 2022; 28:e936292
01 Jan 2022 : EditorialEditorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Pa...
Med Sci Monit 2022; 28:e935952