01 August 2005
Doxorubicin-induced cataract formation in rats and the inhibitory effects of hazelnut, a natural antioxidant: A histopathological study
Atilla Bayer, Cem Evereklioglu, Erkan Demirkaya, Salih Altun, Yildirim Karslioglu, Gungor SobaciMed Sci Monit 2005; 11(8): BR300-304 :: ID: 201126
Abstract
Background: To investigate whether hazelnut prevents doxorubicin-inducedexperimental cataract in rats. Material/Methods: Seventy-five 4-week-old male Wistar albino rats wererandomized into 5 equal groups. Beginning from 6 weeks of age, the groups were treated with intraperitonealinjections of saline solution or doxorubicin (DR) for 4 weeks. Group 1 received saline solution (0.5ml/200 g) weekly, groups 2 and 4 a cumulative dose of 6 mg/kg (1.5 mg/kg/week) of DR, and groups 3 and5 received a cumulative dose of 12 mg/kg (3 mg/kg/week) DR. All the rats were fed ad libitum with a 24%protein rodent chow. Groups 4 and 5 were additionally fed 5 g/day hazelnut. At the end of the tenth weekthe rats were sacrificed and cataract development was investigated histopathologically. The groups werestatistically compared. Results: All control lenses (group 1) were macroscopically clear. Cataractouschanges were noted in 7 eyes (47%) in group 2 and in 10 (67%) in group 3 (p=0.01). Groups 3 and 5 hadcataractous changes in 4 (27%) and 5 (33%) eyes, respectively (p=0.001). The cataract development ratiowas different between groups 2 and 4 (p=0.013), while there was no such difference between groups 3 and5 (p=0.053). Histopathological findings suggesting cataractogenesis were eosinophilic degeneration, corticallens-fiber cell swelling, and the retention of nuclei in central fibers. Conclusions: Hazelnut preventeddoxorubicin-induced cataract in low doses. Since it has no known harmful effect on healthy cells, itmay be beneficial in humans.
Keywords: Antioxidants - administration & dosage, Antioxidants - metabolism, Antioxidants - pharmacology, Antioxidants - therapeutic use, Cataract - chemically induced, Cataract - metabolism, Cataract - pathology, Cataract - prevention & control, Corylus, Diet, Doxorubicin - antagonists & inhibitors, Doxorubicin - pharmacology, Phytotherapy, Rats, Wistar, Antioxidants - therapeutic use, Cataract - prevention & control, Corylus, Diet, Doxorubicin - pharmacology, Phytotherapy, Rats, Wistar
Editorial
01 August 2022 : Editorial
Editorial: Long-Term Effects of Symptomatic and Asymptomatic SARS-CoV-2 Infection in Children and the Changing Pathogenesis of Common Childhood Viruses Driven by the COVID-19 PandemicDOI: 10.12659/MSM.937927
Med Sci Monit 2022; 28:e937927
In Press
05 Aug 2022 : Clinical Research
A Retrospective Study of 98 Elderly Patients with High-Risk Lateral Femoral Wall Intertrochanteric Hip Frac...Med Sci Monit In Press; DOI: 10.12659/MSM.936923
05 Aug 2022 : Clinical Research
Hemoglobin/Red Blood Cell Distribution Width Ratio in Peripheral Blood Is Positively Associated with Progno...Med Sci Monit In Press; DOI: 10.12659/MSM.937146
04 Aug 2022 : Clinical Research
Radiological Assessment of Prevalance and Quality of Periapical Status of Endodontic TreatmentsMed Sci Monit In Press; DOI: 10.12659/MSM.936569
01 Aug 2022 : Clinical Research
Surgical Management of 48 Patients with Retrosternal Goiter and Tracheal Stenosis: A Retrospective Clinical...Med Sci Monit In Press; DOI: 10.12659/MSM.936637
Most Viewed Current Articles
30 Dec 2021 : Clinical Research
Retrospective Study of Outcomes and Hospitalization Rates of Patients in Italy with a Confirmed Diagnosis o...DOI :10.12659/MSM.935379
Med Sci Monit 2021; 27:e935379
13 Nov 2021 : Clinical Research
Acceptance of COVID-19 Vaccination and Its Associated Factors Among Cancer Patients Attending the Oncology ...DOI :10.12659/MSM.932788
Med Sci Monit 2021; 27:e932788
08 Mar 2022 : Review article
A Review of the Potential Roles of Antioxidant and Anti-Inflammatory Pharmacological Approaches for the Man...DOI :10.12659/MSM.936292
Med Sci Monit 2022; 28:e936292
01 Nov 2020 : Review article
Long-Term Respiratory and Neurological Sequelae of COVID-19DOI :10.12659/MSM.928996
Med Sci Monit 2020; 26:e928996