01 August 2005
Physiology and pathophysiology of glucagon-like peptide-1 (GLP-1): The role of GLP-1 in the pathogenesis of diabetes mellitus, obesity, and stress.Ewa Bojanowska
Med Sci Monit 2005; 11(8): RA271-278 :: ID: 202792
Glucagon-like peptide-1 (GLP-1) is produced both in the human and rat intestineand brain. The release of GLP-1 into the blood is mediated by factors of neural and hormonal origin andis stimulated by the presence of nutrients in the digestive tract, while the enzyme dipeptidyl peptidaseIV and the kidneys are responsible for, respectively, the rapid degradation and excretion of the hormone.Peripherally secreted GLP-1 enhances insulin synthesis and release and maintains the normal anatomicalstatus of pancreatic islets. Diminished GLP-1 response to ingested food, associated with attenuated insulinrelease and glucose intolerance, was found in non-insulin-dependent diabetes mellitus. GLP-1 replacementin diabetic subjects normalized these parameters, thus indicating a role for this peptide in the pathogenesisof type 2 diabetes. GLP-1 might also be involved in the pathophysiology of obesity and stress to someextent. Both peripheral and central GLP-1 are probably involved in the control of feeding centers asan anorexic agent. GLP-1 affects the activity of the hypothalamo-pituitary-adrenal axis both under basaland stress conditions, including taste aversion learning. Hence, GLP-1-dependent pathophysiological mechanismsmay participate in the pathogenesis of the most common metabolic and behavioral disorders.
Keywords: Obesity - metabolism, Peptide Fragments - secretion, Protein Precursors - secretion, Diabetes Mellitus - metabolism, Glucagon - secretion, Glucagon-Like Peptide 1, Obesity - metabolism, Pancreas - metabolism, Peptide Fragments - secretion, Protein Precursors - secretion, Stress, Physiological - metabolism
12 September 2022 : EditorialEditorial: Treatment with Dual Incretin Receptor Agonists to Maintain Normal Glucose Levels May Also Maintain Normal Weight and Control Metabolic Dysfunction-Associated Fatty Liver Disease (MAFLD)
Med Sci Monit 2022; 28:e938365
16 September 2022 : Review articleEffects of Physiotherapy on Rehabilitation and Quality of Life in Patients Hospitalized for COVID-19: A Rev...
Med Sci Monit In Press; DOI: 10.12659/MSM.938141
12 September 2022 : Clinical ResearchEffect of Vitamin D Concentration on Course of COVID-19
Med Sci Monit In Press; DOI: 10.12659/MSM.937741
29 August 2022 : Database AnalysisTranscriptome Analysis of Peripheral Blood Mononuclear Cells Response in Patients with Severe COVID-19 Reve...
Med Sci Monit 2022; 28:e937532
26 Sep 2022 : Clinical ResearchDistribution and Determinants of Plasma Homocysteine Levels in a Preconception Population: A Retrospective ...
Med Sci Monit In Press; DOI: 10.12659/MSM.937987
26 Sep 2022 : Clinical ResearchLatency and Interpeak Interval Values of Auditory Brainstem Response in 73 Individuals with Normal Hearing
Med Sci Monit In Press; DOI: 10.12659/MSM.937847
23 Sep 2022 : Review articleA Review of the Role of Ultrasound Radiomics and Its Application and Limitations in the Investigation of Th...
Med Sci Monit In Press; DOI: 10.12659/MSM.937738
Most Viewed Current Articles
30 Dec 2021 : Clinical ResearchRetrospective Study of Outcomes and Hospitalization Rates of Patients in Italy with a Confirmed Diagnosis o...
Med Sci Monit 2021; 27:e935379
13 Nov 2021 : Clinical ResearchAcceptance of COVID-19 Vaccination and Its Associated Factors Among Cancer Patients Attending the Oncology ...
Med Sci Monit 2021; 27:e932788
08 Mar 2022 : Review articleA Review of the Potential Roles of Antioxidant and Anti-Inflammatory Pharmacological Approaches for the Man...
Med Sci Monit 2022; 28:e936292