Logo Medical Science Monitor

Call: +1.631.470.9640
Mon - Fri 10:00 am - 02:00 pm EST

Contact Us

Logo Medical Science Monitor Logo Medical Science Monitor Logo Medical Science Monitor

18 June 2002

Further arguments against including trisialo-Fe2-transferrin in carbohydrate-deficienttransferrin (CDT): a study on male alcoholics and hazardous drinkers.

Torsten Arndt, Aleksander Korzec, Marij Bär, Jürgen Kropf

Med Sci Monit 2002; 8(6): CR411-418 :: ID: 420816


BACKGROUND: We attempted to determine whether including trisialo-Fe2-transferrinin carbohydrate-deficient transferrin (CDT) affects the diagnostic accuracy of CDT as a marker of chronicexcessive alcohol intake.MATERIAL/METHODS: The criterion standard tests for the diagnosis of alcoholismand alcohol intake were the Composite International Diagnostic Interview (CIDI) and the Timeline-Followback(TLFB). The study groups (alcohol intake in each of the last 4 weeks before blood sampling) were comprisedof 56 controls (280 g/week, no alcoholism),63 alcoholics (>280 g/week, alcoholism diagnosis). CDT analysis was performed with %CDTri-TIA, whichincludes about 50% of trisialo-Fe2-transferrin in CDT, and ChronAlcoI.D, which excludes this transferrinisoform from CDT.RESULTS: Depending on the cut-offs for the CDT/transferrin ratio (upper or lower limitof the test-specific borderlines) and on the patient group, the diagnostic sensitivity was 28.1%-72.3%for %CDTri-TIA, as opposed to 50.0%-82.5% for ChronAlcoI.D. The diagnostic accuracy was 62.8%-78.5% for%CDTri-TIA and 71.8%-86.6% for ChronAlcoI.D. The latter test consistently showed higher diagnostic sensitivityand accuracy than %CDTri-TIA. The diagnostic specificity was 85.7%-98.2% for %CDTri-TIA and 91.1%-92.2%for ChronAlcoI.D. The areas under the ROC curve were 0.810%-0.885 for %CDTri-TIA and 0.867%-0.896 forChronAlcoI.D.CONCLUSIONS: The present study and data from the literature indicate that including partsof trisialo-Fe2-transferrin by the %CDTri-TIA test significantly reduces the diagnostic sensitivity andthus accuracy of CDT as a marker of chronic excessive alcohol use.

Keywords: Alcoholism, Case-Control Studies, Predictive Value of Tests, Sensitivity and Specificity, Transferrin

Add Comment 0 Comments

459 1


01 June 2023 : Editorial  

Editorial: Infectious Disease Surveillance Using Artificial Intelligence (AI) and its Role in Epidemic and Pandemic Preparedness

Dinah V. Parums
Science Editor, Medical Science Monitor, International Scientific Information, Inc., Melville, NY, USA

DOI: 10.12659/MSM.941209

Med Sci Monit 2023; 29:e941209


In Press

05 Jun 2023 : Laboratory Research  

Comparison of Composite Resin (Duo-Shade) Shade Guide with Vita Ceramic Shades Before and After Chemical an...

Med Sci Monit In Press; DOI: 10.12659/MSM.940949  

01 Jun 2023 : Clinical Research  

Root Canal Numbers and Configurations in 1080 Permanent Canine Teeth in 270 Saudi Subjects Using Cone-Beam ...

Med Sci Monit In Press; DOI: 10.12659/MSM.940472  

01 Jun 2023 : Clinical Research  

Internal Orifice Alloy Closure: A New Procedure for Treatment of Perianal Fistulizing Crohn’s Disease

Med Sci Monit In Press; DOI: 10.12659/MSM.940873  

01 Jun 2023 : Clinical Research  

Effectiveness of Needle Aspiration versus Surgical Excision for Symptomatic Synovial Cysts of the Hip: A Si...

Med Sci Monit In Press; DOI: 10.12659/MSM.940187  

Most Viewed Current Articles

13 Nov 2021 : Clinical Research  

Acceptance of COVID-19 Vaccination and Its Associated Factors Among Cancer Patients Attending the Oncology ...

DOI :10.12659/MSM.932788

Med Sci Monit 2021; 27:e932788


30 Dec 2021 : Clinical Research  

Retrospective Study of Outcomes and Hospitalization Rates of Patients in Italy with a Confirmed Diagnosis o...

DOI :10.12659/MSM.935379

Med Sci Monit 2021; 27:e935379

08 Mar 2022 : Review article  

A Review of the Potential Roles of Antioxidant and Anti-Inflammatory Pharmacological Approaches for the Man...

DOI :10.12659/MSM.936292

Med Sci Monit 2022; 28:e936292

01 Jan 2022 : Editorial  

Editorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Pa...

DOI :10.12659/MSM.935952

Med Sci Monit 2022; 28:e935952

Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750