18 June 2002
Effect of ambroxol on ion transport -- a model study.
Danuta I Kosik-Bogacka, Tomasz TyrakowskiMed Sci Monit 2002; 8(6): BR236-241 :: ID: 420819
Abstract
BACKGROUND: Effect on ambroxol on reflexive physiological reactions ofisolated frog skin was studied with electrophysiological methods designed to assess ion currents occurringin epithelial tissues or organs. The experiments permitted to analyze an effect of ambroxol on regulatorymechanisms, which in turn influence the constant electrical potential defined as PD and reversible changesof this potential during mechanical stimulation (marked as dPD). A contribution of sodium- and chlorideions transport to the value of transepithelial electrical potential of frog skin (before and after ambroxoladministration) has been demonstrated using amiloride - a blocker of sodium ion transport and bumetanide- a blocker of chloride ion transport.MATERIAL/METHODS: The experimental material comprised 34 fragmentsof hybrid frog (Rana esculenta L.), representing 14 specimens. The experiments involved measuring thetransepithelial electrical potential (PD in mV) on an isolated frog skin placed in an Ussing apparatus.RESULTS:It has been demonstrated that ambroxol influences the processes of ion transport (dPD) which in turndepend on mechanical stimulation. The reaction of hyperpolarization decreased immediately after administrationof ambroxol to the stimulating fluid, when transepithelial transport of sodium ion was maintained inthe preparations studied. Consequently, no effect of ambroxol on the frog skin incubated with amiloridewas recorded.CONCLUSIONS: It has been demonstrated, based on the experiments carried out in the presentstudy, that ambroxol can modify processes of ion transport related to activation of sensory receptors.In particular, it can influence the stimulated transepithelial sodium ion transport in frog skin.
Keywords: Ambroxol, in vitro, Ion Transport, Membrane Potentials, Rana esculenta, Skin
408 3
Editorial
01 June 2023 : Editorial
Editorial: Infectious Disease Surveillance Using Artificial Intelligence (AI) and its Role in Epidemic and Pandemic PreparednessDOI: 10.12659/MSM.941209
Med Sci Monit 2023; 29:e941209
In Press
05 Jun 2023 : Laboratory Research
Comparison of Composite Resin (Duo-Shade) Shade Guide with Vita Ceramic Shades Before and After Chemical an...Med Sci Monit In Press; DOI: 10.12659/MSM.940949
01 Jun 2023 : Clinical Research
Root Canal Numbers and Configurations in 1080 Permanent Canine Teeth in 270 Saudi Subjects Using Cone-Beam ...Med Sci Monit In Press; DOI: 10.12659/MSM.940472
01 Jun 2023 : Clinical Research
Internal Orifice Alloy Closure: A New Procedure for Treatment of Perianal Fistulizing Crohn’s DiseaseMed Sci Monit In Press; DOI: 10.12659/MSM.940873
01 Jun 2023 : Clinical Research
Effectiveness of Needle Aspiration versus Surgical Excision for Symptomatic Synovial Cysts of the Hip: A Si...Med Sci Monit In Press; DOI: 10.12659/MSM.940187
Most Viewed Current Articles
13 Nov 2021 : Clinical Research
Acceptance of COVID-19 Vaccination and Its Associated Factors Among Cancer Patients Attending the Oncology ...DOI :10.12659/MSM.932788
Med Sci Monit 2021; 27:e932788
30 Dec 2021 : Clinical Research
Retrospective Study of Outcomes and Hospitalization Rates of Patients in Italy with a Confirmed Diagnosis o...DOI :10.12659/MSM.935379
Med Sci Monit 2021; 27:e935379
08 Mar 2022 : Review article
A Review of the Potential Roles of Antioxidant and Anti-Inflammatory Pharmacological Approaches for the Man...DOI :10.12659/MSM.936292
Med Sci Monit 2022; 28:e936292
01 Jan 2022 : Editorial
Editorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Pa...DOI :10.12659/MSM.935952
Med Sci Monit 2022; 28:e935952