Logo Medical Science Monitor

Call: +1.631.470.9640
Mon - Fri 10:00 am - 02:00 pm EST

Contact Us

Logo Medical Science Monitor Logo Medical Science Monitor Logo Medical Science Monitor

15 May 2002

Effect of combined dopamine and diltiazem on renal function after cardiac surgery.

Senol Yavuz, Nurcan Ayabakan, M Tugrul Goncu, I Ayhan Ozdemir

Med Sci Monit 2002; 8(5): PI45-50 :: ID: 420829

Abstract

BACKGROUND: In order to evaluate the effect of the combined use of dopamineand diltiazem on renal function in patients undergoing coronary artery bypass grafting (CABG), we conducteda prospective randomized study. MATERIAL/METHODS: Sixty patients (8F, 52M) with normal preoperative renalfunction undergoing CABG were divided randomly into four groups, including control (n=15), use of dopamine-only(n=15), use of diltiazem-only (n=15), and combined use of dopamine and diltiazem (n=15). The patientsranged in age from 38 to 74 years (mean 59.3). Drug administration (diltiazem: intravenous infusion of2 microg x kg(-1) x min(-1), dopamine: 2 microg x kg(-1) x min(-1)) was initiated 24 hours before surgeryand was continued for 72 hours. RESULTS: Creatinine and osmotic clearances were found to be significantlyhigher in the combined group compared with the other groups 24 hours after surgery (p<0.05). There was no significant difference in respect to creatinine clearance, osmotic clearance, and free water clearance in the dopamine-only and diltiazem-only groups compared to the control group. The free water clearance at 24 and 72 hours after surgery were significantly higher in the combined group compared with the other groups (p<0.05). In the control group, dopamine-only, and diltiazem-only groups b2-microglobulin was statistically higher 72 hours postoperative than preoperatively (p<0.05). There were no significant changes in β2-microglobulin levels in the combined group.
Conclusions: The combined use of dopamine and diltiazem may provide a positive contribution and sufficient protection for early postoperative renal function in patients undergoing CABG.

Keywords: Cardiac Output, Cardiotonic Agents, Cardiovascular Agents, Coronary Artery Bypass, Creatinine, diltiazem, Dopamine, Drug Therapy, Combination, Kidney, Kidney Failure, Acute, Osmosis, Prospective Studies, Random Allocation, Time Factors

Add Comment 0 Comments

606 11

Editorial

01 June 2023 : Editorial  

Editorial: Infectious Disease Surveillance Using Artificial Intelligence (AI) and its Role in Epidemic and Pandemic Preparedness

Dinah V. Parums
Science Editor, Medical Science Monitor, International Scientific Information, Inc., Melville, NY, USA

DOI: 10.12659/MSM.941209

Med Sci Monit 2023; 29:e941209

0:00

In Press

08 Jun 2023 : Clinical Research  

Risk Factors for New Vertebral Compression Fracture After Percutaneous Vertebral Augmentation: A Retrospect...

Med Sci Monit In Press; DOI: 10.12659/MSM.940134  

08 Jun 2023 : Clinical Research  

A Nomogram for Identifying HR+/Her2- Breast Cancer Patients with Positive Sentinel Lymph Nodes and Omitted ...

Med Sci Monit In Press; DOI: 10.12659/MSM.940124  

08 Jun 2023 : Clinical Research  

Burden of COVID-19 on Mental Health of Resident Doctors in Poland

Med Sci Monit In Press; DOI: 10.12659/MSM.940208  

08 Jun 2023 : Clinical Research  

Risk Prediction for Rapidly Progressive Interstitial Lung Disease in Anti-MDA5-Positive Dermatomyositis: Th...

Med Sci Monit In Press; DOI: 10.12659/MSM.940251  

Most Viewed Current Articles

13 Nov 2021 : Clinical Research  

Acceptance of COVID-19 Vaccination and Its Associated Factors Among Cancer Patients Attending the Oncology ...

DOI :10.12659/MSM.932788

Med Sci Monit 2021; 27:e932788

0:00

30 Dec 2021 : Clinical Research  

Retrospective Study of Outcomes and Hospitalization Rates of Patients in Italy with a Confirmed Diagnosis o...

DOI :10.12659/MSM.935379

Med Sci Monit 2021; 27:e935379

08 Mar 2022 : Review article  

A Review of the Potential Roles of Antioxidant and Anti-Inflammatory Pharmacological Approaches for the Man...

DOI :10.12659/MSM.936292

Med Sci Monit 2022; 28:e936292

01 Jan 2022 : Editorial  

Editorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Pa...

DOI :10.12659/MSM.935952

Med Sci Monit 2022; 28:e935952

Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750