15 May 2002
Alcohol consumption and the risk of colorectal cancer at low levels of micronutrient intake.Jürgen Wahrendorf, Beata Tobiasz-Adamczyk, Tadeusz Popiela, Karen Steindorf, Wiesław Jedrychowski, Jan Kulig, Agnieszka Penar
Med Sci Monit 2002; 8(5): CR357-363 :: ID: 420836
BACKGROUND: The purpose of our study was to assess the relationship betweensimultaneous exposure to alcohol and consumption of micronutrients that may have protective propertiesagainst colorectal cancer. MATERIAL/METHODS: This hospital-based case-control study of colorectal cancerwas carried out between January 1998 and November 1999 in Cracow, Poland. A total of 180 cases of colorectalcancer confirmed by histopathology were recruited from the University Hospital in Cracow. An equal numberof controls, individually matched by gender and age (+/- 5 years) were chosen from among patients fromthe same hospital with no history of cancer. An interviewer-administered food frequency questionnairecovering 148 food items, including the quantity consumed, was used to assess the typical dietary pattern.RESULTS: When the analysis was carried out on quartile intake data, a consistent inverse associationwas confirmed between the intake of retinol, thiamine or antioxidant micronutrients (carotene, vitaminC and E) and the occurrence of colorectal cancer. Alcohol intake appeared to be an important risk factorfor this cancer site, and the risk increased with the amount of pure alcohol intake. The group with deficientintake of retinol, carotene, and vitamins C and E, but with higher consumption of alcohol, incur a noticeablyhigh risk of colorectal cancer (OR=6.79; 95%CI: 2.08-22.18). CONCLUSIONS: The data support the hypothesisthat higher consumption of alcohol, when combined with low micronutrient intake, may considerably increasethe risk of colorectal cancer.
Keywords: Alcohol Drinking, Ascorbic Acid, Carotenoids, Colorectal Neoplasms, Micronutrients, Odds Ratio, Research Support, Non-U.S. Gov, Risk Factors, thiamine, Vitamin A, Vitamin E
01 June 2023 : EditorialEditorial: Infectious Disease Surveillance Using Artificial Intelligence (AI) and its Role in Epidemic and Pandemic Preparedness
Med Sci Monit 2023; 29:e941209
08 Jun 2023 : Clinical ResearchRisk Factors for New Vertebral Compression Fracture After Percutaneous Vertebral Augmentation: A Retrospect...
Med Sci Monit In Press; DOI: 10.12659/MSM.940134
08 Jun 2023 : Clinical ResearchA Nomogram for Identifying HR+/Her2- Breast Cancer Patients with Positive Sentinel Lymph Nodes and Omitted ...
Med Sci Monit In Press; DOI: 10.12659/MSM.940124
08 Jun 2023 : Clinical ResearchBurden of COVID-19 on Mental Health of Resident Doctors in Poland
Med Sci Monit In Press; DOI: 10.12659/MSM.940208
08 Jun 2023 : Clinical ResearchRisk Prediction for Rapidly Progressive Interstitial Lung Disease in Anti-MDA5-Positive Dermatomyositis: Th...
Med Sci Monit In Press; DOI: 10.12659/MSM.940251
Most Viewed Current Articles
13 Nov 2021 : Clinical ResearchAcceptance of COVID-19 Vaccination and Its Associated Factors Among Cancer Patients Attending the Oncology ...
Med Sci Monit 2021; 27:e932788
30 Dec 2021 : Clinical ResearchRetrospective Study of Outcomes and Hospitalization Rates of Patients in Italy with a Confirmed Diagnosis o...
Med Sci Monit 2021; 27:e935379
08 Mar 2022 : Review articleA Review of the Potential Roles of Antioxidant and Anti-Inflammatory Pharmacological Approaches for the Man...
Med Sci Monit 2022; 28:e936292
01 Jan 2022 : EditorialEditorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Pa...
Med Sci Monit 2022; 28:e935952