Logo Medical Science Monitor

Call: +1.631.470.9640
Mon - Fri 10:00 am - 02:00 pm EST

Contact Us

Logo Medical Science Monitor Logo Medical Science Monitor Logo Medical Science Monitor

15 May 2002

Alcohol consumption and the risk of colorectal cancer at low levels of micronutrient intake.

Wiesław Jedrychowski, Karen Steindorf, Tadeusz Popiela, Jürgen Wahrendorf, Beata Tobiasz-Adamczyk, Jan Kulig, Agnieszka Penar

Med Sci Monit 2002; 8(5): CR357-363 :: ID: 420836

Abstract

BACKGROUND: The purpose of our study was to assess the relationship betweensimultaneous exposure to alcohol and consumption of micronutrients that may have protective propertiesagainst colorectal cancer. MATERIAL/METHODS: This hospital-based case-control study of colorectal cancerwas carried out between January 1998 and November 1999 in Cracow, Poland. A total of 180 cases of colorectalcancer confirmed by histopathology were recruited from the University Hospital in Cracow. An equal numberof controls, individually matched by gender and age (+/- 5 years) were chosen from among patients fromthe same hospital with no history of cancer. An interviewer-administered food frequency questionnairecovering 148 food items, including the quantity consumed, was used to assess the typical dietary pattern.RESULTS: When the analysis was carried out on quartile intake data, a consistent inverse associationwas confirmed between the intake of retinol, thiamine or antioxidant micronutrients (carotene, vitaminC and E) and the occurrence of colorectal cancer. Alcohol intake appeared to be an important risk factorfor this cancer site, and the risk increased with the amount of pure alcohol intake. The group with deficientintake of retinol, carotene, and vitamins C and E, but with higher consumption of alcohol, incur a noticeablyhigh risk of colorectal cancer (OR=6.79; 95%CI: 2.08-22.18). CONCLUSIONS: The data support the hypothesisthat higher consumption of alcohol, when combined with low micronutrient intake, may considerably increasethe risk of colorectal cancer.

Keywords: Alcohol Drinking, Ascorbic Acid, Carotenoids, Colorectal Neoplasms, Micronutrients, Odds Ratio, Research Support, Non-U.S. Gov, Risk Factors, thiamine, Vitamin A, Vitamin E

Add Comment 0 Comments

Editorial

01 April 2025 : Editorial  

Editorial: Rapid Testing for the Avian Influenza A(H5N1) Virus is Urgently Required as Infections in Poultry and Dairy Cows are on the Rise, and so is Transmission to Humans

Dinah V. Parums

DOI: 10.12659/MSM.949109

Med Sci Monit 2025; 31:e949109

0:00

In Press

Clinical Research  

Use of The Mirror-Image Technique for Patient-Specific Reconstruction of Cuboid Fractures

Med Sci Monit In Press; DOI: 10.12659/MSM.947437  

Laboratory Research  

Retention of 3-D-Printed, Milled, and Conventionally Fabricated Occlusal Splints

Med Sci Monit In Press; DOI: 10.12659/MSM.947342  

Review article  

A Review of Circulating Tumor DNA (ctDNA) and the Liquid Biopsy in Cancer Diagnosis, Screening, and Monitor...

Med Sci Monit In Press; DOI: 10.12659/MSM.949300  

Clinical Research  

Buccal Acupuncture Reduces the Dose of Sufentanil Needed in Laparoscopic Gynecological Surgery

Med Sci Monit In Press; DOI: 10.12659/MSM.947088  

Most Viewed Current Articles

17 Jan 2024 : Review article   7,932,846

Vaccination Guidelines for Pregnant Women: Addressing COVID-19 and the Omicron Variant

DOI :10.12659/MSM.942799

Med Sci Monit 2024; 30:e942799

0:00

16 May 2023 : Clinical Research   702,905

Electrophysiological Testing for an Auditory Processing Disorder and Reading Performance in 54 School Stude...

DOI :10.12659/MSM.940387

Med Sci Monit 2023; 29:e940387

0:00

01 Mar 2024 : Editorial   29,808

Editorial: First Regulatory Approvals for CRISPR-Cas9 Therapeutic Gene Editing for Sickle Cell Disease and ...

DOI :10.12659/MSM.944204

Med Sci Monit 2024; 30:e944204

0:00

28 Jan 2024 : Review article   23,790

A Review of IgA Vasculitis (Henoch-Schönlein Purpura) Past, Present, and Future

DOI :10.12659/MSM.943912

Med Sci Monit 2024; 30:e943912

0:00

Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750