15 May 2002
Alcohol consumption and the risk of colorectal cancer at low levels of micronutrient intake.
Wiesław Jedrychowski, Karen Steindorf, Tadeusz Popiela, Jürgen Wahrendorf, Beata Tobiasz-Adamczyk, Jan Kulig, Agnieszka PenarMed Sci Monit 2002; 8(5): CR357-363 :: ID: 420836
Abstract
BACKGROUND: The purpose of our study was to assess the relationship betweensimultaneous exposure to alcohol and consumption of micronutrients that may have protective propertiesagainst colorectal cancer. MATERIAL/METHODS: This hospital-based case-control study of colorectal cancerwas carried out between January 1998 and November 1999 in Cracow, Poland. A total of 180 cases of colorectalcancer confirmed by histopathology were recruited from the University Hospital in Cracow. An equal numberof controls, individually matched by gender and age (+/- 5 years) were chosen from among patients fromthe same hospital with no history of cancer. An interviewer-administered food frequency questionnairecovering 148 food items, including the quantity consumed, was used to assess the typical dietary pattern.RESULTS: When the analysis was carried out on quartile intake data, a consistent inverse associationwas confirmed between the intake of retinol, thiamine or antioxidant micronutrients (carotene, vitaminC and E) and the occurrence of colorectal cancer. Alcohol intake appeared to be an important risk factorfor this cancer site, and the risk increased with the amount of pure alcohol intake. The group with deficientintake of retinol, carotene, and vitamins C and E, but with higher consumption of alcohol, incur a noticeablyhigh risk of colorectal cancer (OR=6.79; 95%CI: 2.08-22.18). CONCLUSIONS: The data support the hypothesisthat higher consumption of alcohol, when combined with low micronutrient intake, may considerably increasethe risk of colorectal cancer.
Keywords: Alcohol Drinking, Ascorbic Acid, Carotenoids, Colorectal Neoplasms, Micronutrients, Odds Ratio, Research Support, Non-U.S. Gov, Risk Factors, thiamine, Vitamin A, Vitamin E
Editorial
01 April 2025 : Editorial
Editorial: Rapid Testing for the Avian Influenza A(H5N1) Virus is Urgently Required as Infections in Poultry and Dairy Cows are on the Rise, and so is Transmission to HumansDOI: 10.12659/MSM.949109
Med Sci Monit 2025; 31:e949109
In Press
Clinical Research
Use of The Mirror-Image Technique for Patient-Specific Reconstruction of Cuboid FracturesMed Sci Monit In Press; DOI: 10.12659/MSM.947437
Laboratory Research
Retention of 3-D-Printed, Milled, and Conventionally Fabricated Occlusal SplintsMed Sci Monit In Press; DOI: 10.12659/MSM.947342
Review article
A Review of Circulating Tumor DNA (ctDNA) and the Liquid Biopsy in Cancer Diagnosis, Screening, and Monitor...Med Sci Monit In Press; DOI: 10.12659/MSM.949300
Clinical Research
Buccal Acupuncture Reduces the Dose of Sufentanil Needed in Laparoscopic Gynecological SurgeryMed Sci Monit In Press; DOI: 10.12659/MSM.947088
Most Viewed Current Articles
17 Jan 2024 : Review article 7,932,846
Vaccination Guidelines for Pregnant Women: Addressing COVID-19 and the Omicron VariantDOI :10.12659/MSM.942799
Med Sci Monit 2024; 30:e942799
16 May 2023 : Clinical Research 702,905
Electrophysiological Testing for an Auditory Processing Disorder and Reading Performance in 54 School Stude...DOI :10.12659/MSM.940387
Med Sci Monit 2023; 29:e940387
01 Mar 2024 : Editorial 29,808
Editorial: First Regulatory Approvals for CRISPR-Cas9 Therapeutic Gene Editing for Sickle Cell Disease and ...DOI :10.12659/MSM.944204
Med Sci Monit 2024; 30:e944204
28 Jan 2024 : Review article 23,790
A Review of IgA Vasculitis (Henoch-Schönlein Purpura) Past, Present, and FutureDOI :10.12659/MSM.943912
Med Sci Monit 2024; 30:e943912