Logo Medical Science Monitor

Call: +1.631.470.9640
Mon - Fri 10:00 am - 02:00 pm EST

Contact Us

Logo Medical Science Monitor Logo Medical Science Monitor Logo Medical Science Monitor

15 May 2002

QT interval in normal infants during sleep with concurrent evaluation of QTcorrection formulae.

Jose Ramet, Avram Benatar, Tine Decraene, Yvan Vandenplas

Med Sci Monit 2002; 8(5): CR351-356 :: ID: 420837

Abstract

BACKGROUND: Physiological changes in the QT interval caused by sleep areimportant in the evaluation of the normal QT interval. Traditionally, Bazett's formula is used for correctingthe QT interval for heart rate in childhood. We set out to establish the QT-RR relationship in infantsduring sleep and concurrently test the performance of four QT correction formulae to determine theircomparability and clinical utility. MATERIAL/METHODS: 130 healthy term born infants undergoing routine8-hour polysomnography were enrolled. Continuous EKG limb lead II recording, saturation monitoring, andelectroencephalography were conducted. QT intervals and heart rate were measured manually digitally on-screenat hourly intervals. The QT-RR relationship was plotted and QTc calculated using the Bazett, Hodges,Fridericia and Framingham formulae. QTc values for each formula were plotted against age and RR interval.Analysis of variance and regression analysis were used to compare the four formulae and the QT-RR relationship.RESULTS: Mean age was 17.7 weeks (range 4-72) and mean weight 6.3 kg (range 2.68-12.7). The QT-RR relationshipduring sleep is curvilinear and appears to be slightly shifted. With increasing heart rate and youngerage the Bazett and Hodges formulae overcorrect the QTc whereas the Fridericia and Framingham formulaeundercorrect. The Hodges formula correlated best with the RR interval. CONCLUSIONS: These formulae arestrongly dependent on heart rate. In the setting of a borderline QTc Bazett prolongation, Hodges formulamay be a useful adjunct. Normal infants may have a slightly longer QTc Bazett during sleep.

Keywords: Algorithms, Analysis of Variance, Arrhythmia, Body Weight, Child, Preschool, Comparative Study, Electrocardiography, Heart Rate, Reference Values, Regression Analysis, Sleep Disorders, Time Factors

Add Comment 0 Comments

Editorial

01 May 2024 : Editorial  

Editorial: First Regulatory Approval for Adoptive Cell Therapy with Autologous Tumor-Infiltrating Lymphocytes (TILs) – Lifileucel (Amtagvi)

Dinah V. Parums

DOI: 10.12659/MSM.944927

Med Sci Monit 2024; 30:e944927

In Press

07 May 2024 : Clinical Research  

Treatment of AVN-Induced Proximal Pole Scaphoid Nonunion Using a Fifth and Fourth Extensor Compartmental Ar...

Med Sci Monit In Press; DOI: 10.12659/MSM.944553  

16 Mar 2024 : Clinical Research  

Diagnostic Efficiency of ACR-TIRADS Score for Differentiating Benign and Malignant Thyroid Nodules of Vario...

Med Sci Monit In Press; DOI: 10.12659/MSM.943228  

08 May 2024 : Clinical Research  

Effect of Individualized PEEP Guided by Driving Pressure on Diaphragm Function in Patients Undergoing Lapar...

Med Sci Monit In Press; DOI: 10.12659/MSM.944022  

21 Mar 2024 : Clinical Research  

Impact of Serum Vitamin D, B6, and B12 and Cognitive Functions on Quality of Life in Peri- and Postmenopaus...

Med Sci Monit In Press; DOI: 10.12659/MSM.943249  

Most Viewed Current Articles

17 Jan 2024 : Review article  

Vaccination Guidelines for Pregnant Women: Addressing COVID-19 and the Omicron Variant

DOI :10.12659/MSM.942799

Med Sci Monit 2024; 30:e942799

0:00

14 Dec 2022 : Clinical Research  

Prevalence and Variability of Allergen-Specific Immunoglobulin E in Patients with Elevated Tryptase Levels

DOI :10.12659/MSM.937990

Med Sci Monit 2022; 28:e937990

0:00

16 May 2023 : Clinical Research  

Electrophysiological Testing for an Auditory Processing Disorder and Reading Performance in 54 School Stude...

DOI :10.12659/MSM.940387

Med Sci Monit 2023; 29:e940387

0:00

01 Jan 2022 : Editorial  

Editorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Pa...

DOI :10.12659/MSM.935952

Med Sci Monit 2022; 28:e935952

0:00

Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750