15 May 2002
Relationship of the BCR gene breakpoint and the type of BCR/ABL transcript to clinical course, prognostic indexes and survival in patients with chronic myeloid leukemia.Witold Prejzner
Med Sci Monit 2002; 8(5): BR193-197 :: ID: 420845
BACKGROUND: Chronic myeloid leukemia is characterized by the presence ofthe Philadelphia chromosome. At the molecular level a fusion of part of the ABL and BCR genes is observed.The breakpoint locations in the BCR gene fall between exons b2a2 or b3a2 (5' and 3', respectively). Dependingon the BCR gene breakpoint two types of mRNA are created. Differences in the types of transcripts and/orthe breakpoint site may have an influence on the clinical course of the disease. This prompted the presentauthor to separate subtypes of chronic myeloid leukemia on the molecular level. MATERIAL/METHODS: 71patients diagnosed with chronic myeloid leukemia in the chronic phase were enrolled in the study. In61 patients the type of BCR/ABL transcript was determined, and in 27 patients BCR breakpoints were established.Possible correlations between the clinical course, prognostic indexes, survival and the type of transcriptand breakpoint were examined. RESULTS: No correlation between the clinical course, prognostic index,or survival was observed in patients with 5' and 3' breakpoints. The patients with b3a2 transcript experiencedlonger survival than the patients expressing b2a2 transcript. However, no significant differences wereobserved in the duration of the chronic phase between the two groups. CONCLUSIONS: The type of BCR genebreakpoint seems to have no prognostic value in patients with chronic myeloid leukemia. The longer survivalof patients expressing the b3a2 transcript may be caused by the less aggressive course of the acceleratedor blastic phase.
Keywords: Adolescent, DNA Damage, Fusion Proteins, bcr-abl, Genes, abl, Leukemia, Myeloid, Chronic, Mutation, Prognosis, RNA, Messenger, Reverse Transcriptase Polymerase Chain Reaction, Time Factors
01 June 2023 : EditorialEditorial: Infectious Disease Surveillance Using Artificial Intelligence (AI) and its Role in Epidemic and Pandemic Preparedness
Med Sci Monit 2023; 29:e941209
08 Jun 2023 : Clinical ResearchRisk Factors for New Vertebral Compression Fracture After Percutaneous Vertebral Augmentation: A Retrospect...
Med Sci Monit In Press; DOI: 10.12659/MSM.940134
08 Jun 2023 : Clinical ResearchA Nomogram for Identifying HR+/Her2- Breast Cancer Patients with Positive Sentinel Lymph Nodes and Omitted ...
Med Sci Monit In Press; DOI: 10.12659/MSM.940124
08 Jun 2023 : Clinical ResearchBurden of COVID-19 on Mental Health of Resident Doctors in Poland
Med Sci Monit In Press; DOI: 10.12659/MSM.940208
08 Jun 2023 : Clinical ResearchRisk Prediction for Rapidly Progressive Interstitial Lung Disease in Anti-MDA5-Positive Dermatomyositis: Th...
Med Sci Monit In Press; DOI: 10.12659/MSM.940251
Most Viewed Current Articles
13 Nov 2021 : Clinical ResearchAcceptance of COVID-19 Vaccination and Its Associated Factors Among Cancer Patients Attending the Oncology ...
Med Sci Monit 2021; 27:e932788
30 Dec 2021 : Clinical ResearchRetrospective Study of Outcomes and Hospitalization Rates of Patients in Italy with a Confirmed Diagnosis o...
Med Sci Monit 2021; 27:e935379
08 Mar 2022 : Review articleA Review of the Potential Roles of Antioxidant and Anti-Inflammatory Pharmacological Approaches for the Man...
Med Sci Monit 2022; 28:e936292
01 Jan 2022 : EditorialEditorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Pa...
Med Sci Monit 2022; 28:e935952