Logo Medical Science Monitor

Call: +1.631.470.9640
Mon - Fri 10:00 am - 02:00 pm EST

Contact Us

Logo Medical Science Monitor Logo Medical Science Monitor Logo Medical Science Monitor

01 January 2002

A radical approach to cancer.

Undurti Das

Med Sci Monit 2002; 8(4): RA79-92 :: ID: 420857


Reactive oxygen species are known to be potentially dangerous, but arealso needed for signal-transduction pathways. Tumor cells have relatively low amounts of superoxide dismutase(SOD), which quenches superoxide anion (O2(-*)), and as a result of a higher level of aerobic metabolism,higher concentrations of O2(-*) , compared to normal cells. But this may not be true of all tumor cells.Some tumor cells have relatively higher amounts of vitamin E, a potent anti-oxidant, and a higher levelof anaerobic metabolism, resulting in a balance that is tilted more towards higher anti-oxidant capacity.In both instances of higher aerobic and anaerobic metabolism methods designed to augment free radicalgeneration in tumor cells can cause their death. It is suggested that free radicals and lipid peroxidessuppress the expression of Bcl-2, activate caspases and shorten telomere, and thus inducing apoptosisof tumor cells. Ionizing radiation, anthracyclines, bleomycin and cytokines produce free radicals andthus are useful as anti-cancer agents. But they also produce many side-effects. 2-methoxyoestradiol andpolyunsaturated fatty acids (PUFAs) inhibit SODs and cause an increase of O2(-*) in tumor cells leadingto their death. In addition, PUFAs (especially gamma-linolenic acid), 2-methoxyoestradiol and thalidomidemay possess anti-angiogenic activity. This suggests that free radicals can suppress angiogenesis. Limitedclinical studies done with gamma-linolenic acid showed that it can regress human brain gliomas withoutany significant side-effects. Thus, PUFAs, thalidomide and 2-methoxyoestradiol or their derivatives mayoffer a new radical approach to the treatment of cancer.

Keywords: Anaerobiosis, Angiogenesis Inhibitors, Cell Division, Estradiol, Fatty Acids, Unsaturated, Free Radicals, Lipid Peroxidation, Neoplasm Proteins, Neoplasms, Neovascularization, Pathologic, Superoxides, Telomere, thalidomide, Vitamin E

Add Comment 0 Comments

747 110


01 December 2023 : Editorial  

Editorial: Outbreaks of Post-Pandemic Childhood Pneumonia and the Re-Emergence of Endemic Respiratory Infections

Dinah V. Parums

DOI: 10.12659/MSM.943312

Med Sci Monit 2023; 29:e943312


In Press

08 Dec 2023 : Clinical Research  

Association Between Influenza Vaccine Uptake and Health Awareness: A Cross-Sectional Questionnaire-Based St...

Med Sci Monit In Press; DOI:  

04 Dec 2023 : Animal Research  

Effects of Intrathecal Ketamine on Cerebrospinal Fluid Levels of Brain-Derived Neurotrophic Factor and Mech...

Med Sci Monit In Press; DOI:  

01 Dec 2023 : Clinical Research  

Risk Factors and Clinical Outcomes of COVID-19 Infection in Multiple Sclerosis Patients: A Retrospective St...

Med Sci Monit In Press; DOI:  

30 Nov 2023 : Review article  

Decoding the Neurological Sequelae of General Anesthesia: A Review

Med Sci Monit In Press; DOI:  

Most Viewed Current Articles

13 Nov 2021 : Clinical Research  

Acceptance of COVID-19 Vaccination and Its Associated Factors Among Cancer Patients Attending the Oncology ...

DOI :10.12659/MSM.932788

Med Sci Monit 2021; 27:e932788


30 Dec 2021 : Clinical Research  

Retrospective Study of Outcomes and Hospitalization Rates of Patients in Italy with a Confirmed Diagnosis o...

DOI :10.12659/MSM.935379

Med Sci Monit 2021; 27:e935379


14 Dec 2022 : Clinical Research  

Prevalence and Variability of Allergen-Specific Immunoglobulin E in Patients with Elevated Tryptase Levels

DOI :10.12659/MSM.937990

Med Sci Monit 2022; 28:e937990


08 Mar 2022 : Review article  

A Review of the Potential Roles of Antioxidant and Anti-Inflammatory Pharmacological Approaches for the Man...

DOI :10.12659/MSM.936292

Med Sci Monit 2022; 28:e936292


Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750