Logo Medical Science Monitor

Call: +1.631.470.9640
Mon - Fri 10:00 am - 02:00 pm EST

Contact Us

Logo Medical Science Monitor Logo Medical Science Monitor Logo Medical Science Monitor

01 January 2002

Drug-induced liver damage - a three-year study of patients from one gastroenterological department.

Lukasz Biernat, Marek Hartleb, Anna Kochel

Med Sci Monit 2002; 8(4): CR292-296 :: ID: 420865


BACKGROUND: The aim of our study was to analyze drug-induced liver diseaseover a 3-year period in one gastroenterological department. MATERIAL/METHODS: International consensusstandard definitions and criteria for assessing causality of adverse drug reactions were applied to allpatients with abnormal hepatic test results. RESULTS: Drugs were implicated in hepatic injury in 14 patients(8 females) in whom causal relationship between drug and liver disease was definite or highly probable.The drugs responsible were amoxicillin with clavulanic acid (3 cases), fluvastatin and pravastatin (3cases), antituberculous drugs (2 cases), estrogens, roxithromycin, asacol, satolol, enalapril and thiamazol.A total of 78.6% (11 cases) were classified as hepatocellular or mixed hepatitis, while cholestatic injurywas found in 21.4% (3 cases). There were no lethal or severe (prothrombin < 50%) hepatic drug reactions.In 13 patients the course of liver disease after withdrawal of the offensive drug was either acute orprotracted, while in one patient there was chronic cholestasis (>3 years) resulting from injury to interlobularbile ducts by amoxicllin with clavulanic acid. CONCLUSIONS: A thorough history of drug intake shouldbe taken in all patients presenting with abnormal hepatic test results. Amoxicillin & clavulanic acid,cholesterol-lowering and antituberculin drugs were the most frequent hepatotoxic factors in our patients.In a majority of cases the liver injury was not severe, and resolved after prompt withdrawal of the responsibledrug.

Keywords: Anti-Bacterial Agents, Anti-Inflammatory Agents, Non-Steroidal, Anticholesteremic Agents, Antitubercular Agents, Comorbidity, enalapril, Estrogens, Fatty Liver, Hepatitis, Toxic, Liver Diseases, Mesalamine

Add Comment 0 Comments

798 16


01 December 2023 : Editorial  

Editorial: Outbreaks of Post-Pandemic Childhood Pneumonia and the Re-Emergence of Endemic Respiratory Infections

Dinah V. Parums

DOI: 10.12659/MSM.943312

Med Sci Monit 2023; 29:e943312


In Press

08 Dec 2023 : Clinical Research  

Association Between Influenza Vaccine Uptake and Health Awareness: A Cross-Sectional Questionnaire-Based St...

Med Sci Monit In Press; DOI:  

04 Dec 2023 : Animal Research  

Effects of Intrathecal Ketamine on Cerebrospinal Fluid Levels of Brain-Derived Neurotrophic Factor and Mech...

Med Sci Monit In Press; DOI:  

01 Dec 2023 : Clinical Research  

Risk Factors and Clinical Outcomes of COVID-19 Infection in Multiple Sclerosis Patients: A Retrospective St...

Med Sci Monit In Press; DOI:  

30 Nov 2023 : Review article  

Decoding the Neurological Sequelae of General Anesthesia: A Review

Med Sci Monit In Press; DOI:  

Most Viewed Current Articles

13 Nov 2021 : Clinical Research  

Acceptance of COVID-19 Vaccination and Its Associated Factors Among Cancer Patients Attending the Oncology ...

DOI :10.12659/MSM.932788

Med Sci Monit 2021; 27:e932788


30 Dec 2021 : Clinical Research  

Retrospective Study of Outcomes and Hospitalization Rates of Patients in Italy with a Confirmed Diagnosis o...

DOI :10.12659/MSM.935379

Med Sci Monit 2021; 27:e935379


14 Dec 2022 : Clinical Research  

Prevalence and Variability of Allergen-Specific Immunoglobulin E in Patients with Elevated Tryptase Levels

DOI :10.12659/MSM.937990

Med Sci Monit 2022; 28:e937990


08 Mar 2022 : Review article  

A Review of the Potential Roles of Antioxidant and Anti-Inflammatory Pharmacological Approaches for the Man...

DOI :10.12659/MSM.936292

Med Sci Monit 2022; 28:e936292


Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750