Logo Medical Science Monitor

Call: +1.631.470.9640
Mon - Fri 10:00 am - 02:00 pm EST

Contact Us

Logo Medical Science Monitor Logo Medical Science Monitor Logo Medical Science Monitor

12 March 2002

Resistance of Klebsiella pneumoniae strains producing and not producing ESBL(extended-spectrum beta-lactamase) type enzymes to selected non-beta-lactam antibiotics.

Alicja Sekowska, Grazyna Janicka, Czesław Kłyszejko, Małgorzata Wojda, Marcin Wróblewski, Maria Szymankiewicz

Med Sci Monit 2002; 8(3): BR100-104 :: ID: 420891

Abstract

BACKGROUND: Bacteria of the Klebsiella genus may cause numerous infectionsin human, which are often treated with beta-lactam antibiotics. The fundamental mechanism of Klebsiellaresistance to penicillins or cephalosporins involves the production of enzymes--extended-spectrum beta-lactamases(ESBLs). Because of resistance of many Klebsiella spp. strains to beta-lactams, alternative antibiotictherapy can make use of aminoglycosides and quinolones. MATERIAL/METHODS: The study analyzed the prevalenceof ESBL -type enzymes among 256 Klebsiella pneumoniae strains isolated from various clinical materialscollected from patients hospitalized between 1997 and 2000. ESBLs were detected by double-disk synergytest (DDST). The prevalence of strains resistant to selected aminoglycosides (gentamicin, amikacin, netilmicin)and quinolones (ciprofloxacin, norfloxacin, nalidixic acid) in the particular years was analyzed. Drugsensitivity was determined by disk-diffusion method according to the recommendations of the NationalReference Center for Microbial Drug Sensitivity. RESULTS: During the analyzed time interval, a significantincrease of the number of K. pneumoniae ESBL(+) strains was noted: in 1997 - 16.5% (14/85) and in 2000- 40.4% (22/54) (p<0.001).Among the ESBL(+) strains, an increase of the number of strains resistant to the tested antibiotics, except for nalidixic acid, was demonstrated
Conclusion: A statistically significant increase of multidrug-resistant K. pneumoniae strains, including strains producing ESBLs, was demonstrated in the analyzed material

Keywords: amikacin, Anti-Bacterial Agents, Anti-Infective Agents, Ciprofloxacin, Drug Resistance, Microbial, Gentamicins, Klebsiella pneumoniae, Microbial Sensitivity Tests, Nalidixic Acid, Netilmicin, Norfloxacin, Prevalence, Time Factors, beta-Lactamases

Add Comment 0 Comments

Editorial

01 February 2025 : Editorial  

Editorial: Current Approaches to Screening for Lung Cancer in Smokers and Non-Smokers

Dinah V. Parums

DOI: 10.12659/MSM.948255

Med Sci Monit 2025; 31:e948255

0:00

In Press

Clinical Research  

Immune Dysregulation in Acute Herpes Zoster: Predictive Factors for Postherpetic Neuralgia

Med Sci Monit In Press; DOI: 10.12659/MSM.944688  

0:00

Clinical Research  

Inflammatory Biomarkers from Blood Counts as Prognostic Tools in Metastatic Esophageal Cancer

Med Sci Monit In Press; DOI: 10.12659/MSM.947202  

Laboratory Research  

Comparison of Color Stability Between Single-Shade and Conventional Composite Resins Following Immersion in...

Med Sci Monit In Press; DOI: 10.12659/MSM.946784  

Clinical Research  

Evaluation of Knowledge, Attitudes, and Practices Toward Thyroid Nodules in 456 Patients with Thyroid Nodules

Med Sci Monit In Press; DOI: 10.12659/MSM.945732  

Most Viewed Current Articles

17 Jan 2024 : Review article   6,966,841

Vaccination Guidelines for Pregnant Women: Addressing COVID-19 and the Omicron Variant

DOI :10.12659/MSM.942799

Med Sci Monit 2024; 30:e942799

0:00

16 May 2023 : Clinical Research   701,694

Electrophysiological Testing for an Auditory Processing Disorder and Reading Performance in 54 School Stude...

DOI :10.12659/MSM.940387

Med Sci Monit 2023; 29:e940387

0:00

01 Mar 2024 : Editorial   25,087

Editorial: First Regulatory Approvals for CRISPR-Cas9 Therapeutic Gene Editing for Sickle Cell Disease and ...

DOI :10.12659/MSM.944204

Med Sci Monit 2024; 30:e944204

0:00

28 Jan 2024 : Review article   19,746

A Review of IgA Vasculitis (Henoch-Schönlein Purpura) Past, Present, and Future

DOI :10.12659/MSM.943912

Med Sci Monit 2024; 30:e943912

0:00

Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750