11 March 2002
Role of fasting serum C-peptide as a predictor of cardiovascular risk associated with the metabolic X-syndrome.
Peter Haban, Robert Simoncic, Eva Zidekova, Lubomir OzdinMed Sci Monit 2002; 8(3): CR175-179 :: ID: 420907
Abstract
BACKGROUND: Insulin resistance with increased insulin and C-peptide levelsis the basis of the metabolic X-syndrome, so it is reasonable to expect them to be a good predictor ofassociated cardiovascular risk factors. MATERIAL/METHODS: A total of 29 patients (21 postmenopausal womenand 8 men) with type 2 diabetes mellitus (mean duration 14.6 years, 95% CI 11.9 to 17.3 years), all olderthan 50, were studied for possible links between fasting serum C-peptide levels and other vascular riskfactors. The mean value of the C-peptide in the group was 0.627 nmol/l (95% CI: 0.464 to 0.789 nmol/l).RESULTS: We found statistically significant correlations between C-peptide and triacylglycerols (TG;r=0.474; p=0.009), HDL-cholesterol (inverse; r = -0.567; p = 0.001) and various lipoprotein ratios: atherogenicindex (= total/HDL cholesterol: r = 0.599; p = 0.0006) or TG/HDL (r = 0.587; p = 0.0008). C-peptide alsocorrelated with the body mass index (BMI: r = 0.519; p= 0.004) and leptin (r = 0.492; p = 0.007). Afterthe coefficient CpG (C-peptide x fasting glycemia) was introduced, the correlations with lipoproteinsbecame even stronger. CONCLUSIONS: We suggest that elevated (fasting) serum C-peptide levels constitutea clinically important marker of the cardiovascular risks associated with the metabolic X-syndrome. Itcan be used as an effective tool for the early detection of diabetic patients at particular risk foratherosclerotic cardiovascular diseases and needing early preventive measures or aggressive treatment.
Keywords: C-peptide, Cardiovascular Diseases, Diabetes Mellitus, Type 2, Hyperlipoproteinemia, Insulin, Insulin Resistance, Lipoproteins, Metabolic Syndrome X, Peptides, Postmenopause, Risk Factors
Editorial
15 August 2022 : Editorial
Editorial: The Metabolic (Dysfunction) Associated Fatty Liver Disease (MAFLD)-Non-Alcoholic Fatty Liver Disease (NAFLD) Debate: A Forced Consensus and The Risk of a World DivideDOI: 10.12659/MSM.938080
Med Sci Monit 2022; 28:e938080
In Press
12 Aug 2022 : Clinical Research
Risk Factors and Pathogen Spectrum in Continuous Ambulatory Peritoneal Dialysis-Associated Peritonitis: A S...Med Sci Monit In Press; DOI: 10.12659/MSM.937112
11 Aug 2022 : Meta-Analysis
Optimal Surgical Treatment Method for Anterior Cruciate Ligament Rupture: Results from a Network Meta-AnalysisMed Sci Monit In Press; DOI: 10.12659/MSM.937118
10 Aug 2022 : Review article
Programmed Cell Death in Diabetic Nephropathy: A Review of Apoptosis, Autophagy, and NecroptosisMed Sci Monit In Press; DOI: 10.12659/MSM.937766
10 Aug 2022 : Database Analysis
Use and Effects of Augmentation of Labor with Oxytocin: A Single-Center, Retrospective, Case-Control Study ...Med Sci Monit In Press; DOI: 10.12659/MSM.937557
Most Viewed Current Articles
30 Dec 2021 : Clinical Research
Retrospective Study of Outcomes and Hospitalization Rates of Patients in Italy with a Confirmed Diagnosis o...DOI :10.12659/MSM.935379
Med Sci Monit 2021; 27:e935379
13 Nov 2021 : Clinical Research
Acceptance of COVID-19 Vaccination and Its Associated Factors Among Cancer Patients Attending the Oncology ...DOI :10.12659/MSM.932788
Med Sci Monit 2021; 27:e932788
08 Mar 2022 : Review article
A Review of the Potential Roles of Antioxidant and Anti-Inflammatory Pharmacological Approaches for the Man...DOI :10.12659/MSM.936292
Med Sci Monit 2022; 28:e936292
01 Nov 2020 : Review article
Long-Term Respiratory and Neurological Sequelae of COVID-19DOI :10.12659/MSM.928996
Med Sci Monit 2020; 26:e928996