22 February 2002
Hepatocyte proliferation in health and in liver failure.
Jacek RozgaMed Sci Monit 2002; 8(2): RA32-38 :: ID: 420920
Abstract
Mammalian liver possesses an extraordinary capacity for compensatory growthin response to conditions that induce cell loss by physical, infectious, or toxic injury. In normal animalsand humans, it is a tightly regulated process of both hypertrophy and hyperplasia involving differentliver cell populations and a finely tuned interplay between growth factors, cytokines, extracellularmatrix components and other regulators. The regeneration response is maximal when two-thirds of the liveris resected. When a lesser amount of parenchyma is removed, residual liver grows more slowly. Resectionsexceeding two-thirds of the liver mass also retard and diminish both DNA synthesis and mitotic activityand subtotal (90%) hepatectomy invariably results in the death of rats without regeneration. The underlyingmechanisms of liver growth inhibition are poorly understood. In particular, only a few studies existthat provide insight into the mechanisms that control regeneration after extensive hepatocyte loss. Inthis regard, the role of growth-regulatory factors and other compounds that accumulate in the blood circulationas a result of hepatic insufficiency and liver cell death remains unclear. We have initiated studiesof these mechanisms and demonstrated that in rats with low (10%) hepatocyte mass, a marked and sustainedelevation of blood IL-6, HGF and TGF-b1 levels was associated with lack of hepatocyte proliferation andsuppression of Stat3 DNA binding. While searching for the possible cause of inhibited IL-6/Stat3 signaling,we found that IL-6 receptor (IL-6R & gp130) was preserved, that nuclear Stat3 protein content was lowered,and that IL-6/Stat3 pathway inhibitors (SOCS-1, PIAS3) were induced during the pre-replicative Go-G1period.
Keywords: Cell Division, Hepatocytes, Liver, Liver failure, Liver Regeneration
Editorial
01 February 2023 : Editorial
Editorial: The XBB.1.5 (‘Kraken’) Subvariant of Omicron SARS-CoV-2 and its Rapid Global SpreadDOI: 10.12659/MSM.939580
Med Sci Monit 2023; 29:e939580
SARS-CoV-2/COVID-19
19 January 2023 : Clinical Research
Evaluation of Health-Related Quality of Life and Mental Health in 729 Medical Students in Indonesia During ...Med Sci Monit In Press; DOI: 10.12659/MSM.938892
19 January 2023 : Clinical Research
Determining the Impact of the COVID-19 Pandemic on Dental Care in the Serbian Adult Population: An Online Q...Med Sci Monit 2023; 29:e939238
27 December 2022 : Clinical Research
Effect of Physiotherapy to Correct Rounded Shoulder Posture in 30 Patients During the COVID-19 Pandemic in ...Med Sci Monit 2022; 28:e938926
10 December 2022 : Clinical Research
Retrospective Study to Identify Risk Factors for Severe Disease and Mortality Using the Modified Early Warn...Med Sci Monit 2022; 28:e938647
In Press
03 Feb 2023 : Clinical Research
Treatment of Gingival Recession Defects with Pouch and Tunnel Technique Using Connective Tissue Graft and L...Med Sci Monit In Press; DOI: 10.12659/MSM.938865
02 Feb 2023 : Clinical Research
Online Questionnaire-Based Study to Evaluate the Attitudes and Use of Rubber Dental Dams by Saudi Dental Pr...Med Sci Monit In Press; DOI: 10.12659/MSM.938672
02 Feb 2023 : Database Analysis
Prognostic-Related Biomarkers in Pancreatic Ductal Adenocarcinoma Correlating with Immune Infiltrates Based...Med Sci Monit In Press; DOI: 10.12659/MSM.938785
01 Feb 2023 : Clinical Research
Comparison of 3 Enzyme-Linked Immunoassay Methods to Evaluate Serum Concentrations of Infliximab and Antibo...Med Sci Monit In Press; DOI: 10.12659/MSM.939084
Most Viewed Current Articles
13 Nov 2021 : Clinical Research
Acceptance of COVID-19 Vaccination and Its Associated Factors Among Cancer Patients Attending the Oncology ...DOI :10.12659/MSM.932788
Med Sci Monit 2021; 27:e932788
30 Dec 2021 : Clinical Research
Retrospective Study of Outcomes and Hospitalization Rates of Patients in Italy with a Confirmed Diagnosis o...DOI :10.12659/MSM.935379
Med Sci Monit 2021; 27:e935379
08 Mar 2022 : Review article
A Review of the Potential Roles of Antioxidant and Anti-Inflammatory Pharmacological Approaches for the Man...DOI :10.12659/MSM.936292
Med Sci Monit 2022; 28:e936292
01 Jan 2022 : Editorial
Editorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Pa...DOI :10.12659/MSM.935952
Med Sci Monit 2022; 28:e935952