Logo Medical Science Monitor

Call: +1.631.470.9640
Mon - Fri 10:00 am - 02:00 pm EST

Contact Us

Logo Medical Science Monitor Logo Medical Science Monitor Logo Medical Science Monitor

22 February 2002

Evaluation of lymphocyte subsets and NK cells in septic children.

M Banasik, Jiri Zeman, Teresa Woźniakowska-Gesicka

Med Sci Monit 2002; 8(2): CR119-124 :: ID: 420929


BACKGROUND: Disorders of lymphocyte subpopulations counts and NK cellsmay not only contribute to impaired elimination of pathogens, but also be an important factor in thedevelopment of generalized inflammatory reaction. The aim of the paper was the analysis of subpopulationsof lymphocytes and NK cells in children with sepsis and after recovery. MATERIAL/METHODS: The study comprised25 septic children (17 infants and 8 children aged from 1 to 3 years). The control group consisted of25 healthy children. The study was conducted in the initial phase of sepsis and then repeated 2 to 3months after recovery. In all the children, the percentage and absolute numbers of basic lymphocyte subsetsand NK cells in blood serum were evaluated. RESULTS: In the course of sepsis, the absolute number ofactivated lymphocytes T in the youngest children was higher in comparison with the control group. Afterrecovery, the percentage and absolute counts of CD4 lymphocytes in all the children and CD3/CD4 lymphocytesratio in the youngest children were considerably lower than in the control group. The percentage andabsolute number of NK cells in the youngest children after recovery were higher in comparison with thecontrol group. CONCLUSIONS: In children who underwent sepsis, depression traits of cellular immunityare observed. The occurrence of defensive system disorders after recovery may be an important factorin recurrent infections and creates the necessity of immune system monitoring in children with the historyof sepsis for the purpose of prevention.

Keywords: Case-Control Studies, Child, Preschool, Lymphocyte Subsets, Sepsis

Add Comment 0 Comments


01 June 2024 : Editorial  

Editorial: Concerns as Highly Pathogenic Avian Influenza (HPAI) Virus of the H5N1 Subtype is Identified in Dairy Cows and Other Mammals

Dinah V. Parums

DOI: 10.12659/MSM.945315

Med Sci Monit 2024; 30:e945315


In Press

Clinical Research  

Trust and Support for Cancer Research Biobanks: Insights from Cancer Patients in Poland

Med Sci Monit In Press; DOI: 10.12659/MSM.944263  

Clinical Research  

Morphological and Dimensional Analysis of the Nasopalatine Canal: Insights from Cone-Beam Computed Tomograp...

Med Sci Monit In Press; DOI: 10.12659/MSM.944424  

Clinical Research  

Hemorrhagic Cysts in the Pancreas: Risk Factors, Treatment, and Outcomes – Insights from a Single-Center Study

Med Sci Monit In Press; DOI: 10.12659/MSM.941955  

Clinical Research  

Perioperative Administration of Tranexamic Acid and Low Molecular Weight Heparin for Enhanced Blood Managem...

Med Sci Monit In Press; DOI: 10.12659/MSM.944063  

Most Viewed Current Articles

14 Dec 2022 : Clinical Research   1,421,178

Prevalence and Variability of Allergen-Specific Immunoglobulin E in Patients with Elevated Tryptase Levels

DOI :10.12659/MSM.937990

Med Sci Monit 2022; 28:e937990


17 Jan 2024 : Review article   1,355,487

Vaccination Guidelines for Pregnant Women: Addressing COVID-19 and the Omicron Variant

DOI :10.12659/MSM.942799

Med Sci Monit 2024; 30:e942799


16 May 2023 : Clinical Research   690,090

Electrophysiological Testing for an Auditory Processing Disorder and Reading Performance in 54 School Stude...

DOI :10.12659/MSM.940387

Med Sci Monit 2023; 29:e940387


01 Jan 2022 : Editorial   50,113

Editorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Pa...

DOI :10.12659/MSM.935952

Med Sci Monit 2022; 28:e935952


Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750