17 January 2002
Effect of tissue injury on D-Dimer levels: a prospective study in trauma patients.
Samuel Cemaj, Samir Johna, Richard CatalanoMed Sci Monit 2002; 8(1): CR5-8 :: ID: 420948
Abstract
BACKGROUND: D-Dimer measurement has been used as a simple, non-invasivetest to rule out thromboembolic phenomena in patients at risk for deep venous thrombosis (DVT) and /or pulmonary embolism (PE). Elevated D-Dimer level caused by tissue injury is believed to show a trendfor gradual decrease to normal within the first three days after trauma. MATERIAL/METHODS: To study theeffect of tissue injury on D-Dimer levels, we conducted a prospective measurement of D-Dimer levels inseverely traumatized, high-risk patients for DVT or PE, starting within 24 hours after admission untildisposition of the patient or to a total of 14 days of hospitalization. Patients were observed clinicallyfor development of thromboembolic phenomena, and were subjected to weekly surveillance using duplex scanof the lower extremities. Additional testing was done if requested by the attending trauma surgeon. RESULTS:A total of 21 patients were enrolled in the study. There were 17 males, and 4 females. Patients had amean age of (42) with a range of (17-79), and a mean ISS score of (20) with a range of (4-50). Sevenpatients completed 3-9 days of testing. Fourteen patients had more than 10 days of testing. Nine patientscompleted 14 days of testing. In all patients, tissue injury resulted in increased levels of D-Dimerabove a threshold (500 ng/ml), below which DVT or PE can be ruled out. The increased levels failed tonormalize even when testing was continued for 14 days. CONCLUSIONS: In our study, the increased D-Dimerlevels induced by tissue injury failed to show a trend of gradual return to normal within three daysafter trauma, as currently believed. This, in our opinion, may eliminate our ability to use D-Dimer testingto rule out DVT or PE in a subset of severely traumatized patients in the early post trauma period.
Keywords: Adolescent, Fibrin Fibrinogen Degradation Products, Pulmonary Embolism, Research Support, Non-U.S. Gov, Time Factors, Venous Thrombosis, Wounds and Injuries
Editorial
01 February 2023 : Editorial
Editorial: The XBB.1.5 (‘Kraken’) Subvariant of Omicron SARS-CoV-2 and its Rapid Global SpreadDOI: 10.12659/MSM.939580
Med Sci Monit 2023; 29:e939580
SARS-CoV-2/COVID-19
19 January 2023 : Clinical Research
Evaluation of Health-Related Quality of Life and Mental Health in 729 Medical Students in Indonesia During ...Med Sci Monit In Press; DOI: 10.12659/MSM.938892
19 January 2023 : Clinical Research
Determining the Impact of the COVID-19 Pandemic on Dental Care in the Serbian Adult Population: An Online Q...Med Sci Monit 2023; 29:e939238
27 December 2022 : Clinical Research
Effect of Physiotherapy to Correct Rounded Shoulder Posture in 30 Patients During the COVID-19 Pandemic in ...Med Sci Monit 2022; 28:e938926
10 December 2022 : Clinical Research
Retrospective Study to Identify Risk Factors for Severe Disease and Mortality Using the Modified Early Warn...Med Sci Monit 2022; 28:e938647
In Press
03 Feb 2023 : Clinical Research
Treatment of Gingival Recession Defects with Pouch and Tunnel Technique Using Connective Tissue Graft and L...Med Sci Monit In Press; DOI: 10.12659/MSM.938865
02 Feb 2023 : Clinical Research
Online Questionnaire-Based Study to Evaluate the Attitudes and Use of Rubber Dental Dams by Saudi Dental Pr...Med Sci Monit In Press; DOI: 10.12659/MSM.938672
02 Feb 2023 : Database Analysis
Prognostic-Related Biomarkers in Pancreatic Ductal Adenocarcinoma Correlating with Immune Infiltrates Based...Med Sci Monit In Press; DOI: 10.12659/MSM.938785
01 Feb 2023 : Clinical Research
Comparison of 3 Enzyme-Linked Immunoassay Methods to Evaluate Serum Concentrations of Infliximab and Antibo...Med Sci Monit In Press; DOI: 10.12659/MSM.939084
Most Viewed Current Articles
13 Nov 2021 : Clinical Research
Acceptance of COVID-19 Vaccination and Its Associated Factors Among Cancer Patients Attending the Oncology ...DOI :10.12659/MSM.932788
Med Sci Monit 2021; 27:e932788
30 Dec 2021 : Clinical Research
Retrospective Study of Outcomes and Hospitalization Rates of Patients in Italy with a Confirmed Diagnosis o...DOI :10.12659/MSM.935379
Med Sci Monit 2021; 27:e935379
08 Mar 2022 : Review article
A Review of the Potential Roles of Antioxidant and Anti-Inflammatory Pharmacological Approaches for the Man...DOI :10.12659/MSM.936292
Med Sci Monit 2022; 28:e936292
01 Jan 2022 : Editorial
Editorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Pa...DOI :10.12659/MSM.935952
Med Sci Monit 2022; 28:e935952