Logo Medical Science Monitor

Call: +1.631.470.9640
Closed: National Holiday

Contact Us

Logo Medical Science Monitor Logo Medical Science Monitor Logo Medical Science Monitor

01 January 2001

Influence of the diet made by its family ancestors in the hereditary component of an individual: study in six generations of rats.

Antonio Mendívil

Med Sci Monit 2001; 7(2): BR179-187 :: ID: 421164


BACKGROUND: The prevalence of the deficiency of enzyme Lactase/phlorizinhydrolase (LPH) varies widely between different countries, with a low of 1-3% in Scandinavia and closeto 100% in most of South-East Asia. Various carbohydrates are capable of enhancing LPH mRNA levels inthe small intestine, and that transcriptional control plays a major role in the carbohydrate-inducedalterations of LPH mRNA expression.

MATERIAL AND METHODS: A generation of rats was randomized and assignedto two groups; those that were fed a high-carbohydrate diet and, those that were fed standard rodentmeal. The sixth generation of these animals was fed standard rodent meal. Transfection experiments usingCaco-2 cells were performed using sperm samples of the sixth generation of rats.
RESULTS: This studysuggests that the feeding with a high-carbohydrate diet during five generations of rats increases thecapacity of production of enzyme LPH, LPH mRNA levels and the transcription rate of the LPH gene in thesixth generation of these animals, and this fact happens independently of the diet that this generationof rats had. Transfection experiments show that this influence has had to take place necessarily withinthe hereditary component which the last generation of rats received from its family ancestors.
CONCLUSION:The feeding received by the ancestors of a generation of rats could influence within hereditary componentreceived by them.

Keywords: Evolution, natural selection, darwinism, Lactase, Lamarck, speciation

Add Comment 0 Comments


01 June 2024 : Editorial  

Editorial: Concerns as Highly Pathogenic Avian Influenza (HPAI) Virus of the H5N1 Subtype is Identified in Dairy Cows and Other Mammals

Dinah V. Parums

DOI: 10.12659/MSM.945315

Med Sci Monit 2024; 30:e945315


In Press

Animal Research  

Targeting the Gut-Kidney Axis in Diarrhea with Kidney-Yang Deficiency Syndrome: The Role of Sishen Pills in...

Med Sci Monit In Press; DOI: 10.12659/MSM.944185  

Review article  

A New Pandemic of the XXIst Century: The Growing Crisis of Adolescent Depression in the Digital Age

Med Sci Monit In Press; DOI: 10.12659/MSM.944838  

Review article  

A Review of Wastewater-Based Epidemiology Studies for the Assessment of Over-the-Counter Medicines Used as ...

Med Sci Monit In Press; DOI: 10.12659/MSM.944120  

Clinical Research  

Functional Outcomes of Therapeutic Selective Nerve Root Block for Single-Segment Lumbar Spinal Stenosis: A ...

Med Sci Monit In Press; DOI: 10.12659/MSM.943634  

Most Viewed Current Articles

17 Jan 2024 : Review article   1,652,499

Vaccination Guidelines for Pregnant Women: Addressing COVID-19 and the Omicron Variant

DOI :10.12659/MSM.942799

Med Sci Monit 2024; 30:e942799


14 Dec 2022 : Clinical Research   1,522,350

Prevalence and Variability of Allergen-Specific Immunoglobulin E in Patients with Elevated Tryptase Levels

DOI :10.12659/MSM.937990

Med Sci Monit 2022; 28:e937990


16 May 2023 : Clinical Research   690,265

Electrophysiological Testing for an Auditory Processing Disorder and Reading Performance in 54 School Stude...

DOI :10.12659/MSM.940387

Med Sci Monit 2023; 29:e940387


01 Jan 2022 : Editorial   50,215

Editorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Pa...

DOI :10.12659/MSM.935952

Med Sci Monit 2022; 28:e935952


Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750