Logo Medical Science Monitor

Call: +1.631.470.9640
Mon - Fri 10:00 am - 02:00 pm EST

Contact Us

Logo Medical Science Monitor Logo Medical Science Monitor Logo Medical Science Monitor

01 September 2005

Activities of red blood cell anti-oxidative enzymes (SOD, GPx) and total anti-oxidativecapacity of serum (TAS) in men with coronary atherosclerosis and in healthy pilots.

Ewelina Zawadzka-Bartczak

Med Sci Monit 2005; 11(9): CR440-444 :: ID: 428453

Abstract

Background: Reactive oxygen species (ROS) have been proposed to play importantpathogenic roles, especially in harmful oxidative modifications of low-density cholesterol. Redox balancewithin the organism is largely determined by the activities of anti-oxidative enzymes of red blood cellsand by the total anti-oxidative capacity of the serum (TAS). Material/Methods: SOD and GPx activitiesand TAS in 13 men aged 42-65 years with coronary atherosclerosis (group I) were compared with those ofboth 15 clinically healthy pilots matched for age and lipid abnormalities (cholesterol and triglycerides)(group II) and 14 age-matched pilots without lipid abnormalities (group III). Results: There were statisticallysignificant differences in SOD and GPx activities and in TAS between the groups. Conclusions: 1. SODand GPx activities and TAS were lower in men with advanced coronary atherosclerosis that in age-matchedclinically healthy men with similar dyslipidemia and were even further decreased compared with clinicallyhealthy men without dyslipidemia. 2. The decrease in SOD and GPx activities and TAS in men with advancedcoronary atherosclerosis was more pronounced than the degree of hypercholesterolemia or hypertriglyceridemia.3. If hyperlipidemia and the activity of antioxidative enzymes and TAS were considered without referenceto other risk factors of atherosclerosis, it appeared that the decreases in SOD, GPx, and TAS may playa more important role in the development of the atherosclerotic process than isolated increases in freecholesterol or triglyceride levels.

Keywords: Aerospace Medicine, Antioxidants - metabolism, Case-Control Studies, Cholesterol - blood, Coronary Artery Disease - enzymology, Erythrocytes - enzymology, Glutathione Peroxidase - blood, Reactive Oxygen Species - blood, Superoxide Dismutase - blood, Triglycerides - blood

0 Comments

Editorial

15 August 2022 : Editorial  

Editorial: The Metabolic (Dysfunction) Associated Fatty Liver Disease (MAFLD)-Non-Alcoholic Fatty Liver Disease (NAFLD) Debate: A Forced Consensus and The Risk of a World Divide

Nahum Méndez-Sánchez, Ming-Hua Zheng, Takumi Kawaguchi, Shiv K. Sarin
Liver Research Unit, Medica Sur Clinic & Foundation and Faculty of Medicine, National Autonomous University of Mexico, Mexico City, Mexico

DOI: 10.12659/MSM.938080

Med Sci Monit 2022; 28:e938080

In Press

12 Aug 2022 : Clinical Research  

Risk Factors and Pathogen Spectrum in Continuous Ambulatory Peritoneal Dialysis-Associated Peritonitis: A S...

Med Sci Monit In Press; DOI: 10.12659/MSM.937112  

11 Aug 2022 : Meta-Analysis  

Optimal Surgical Treatment Method for Anterior Cruciate Ligament Rupture: Results from a Network Meta-Analysis

Med Sci Monit In Press; DOI: 10.12659/MSM.937118  

10 Aug 2022 : Review article  

Programmed Cell Death in Diabetic Nephropathy: A Review of Apoptosis, Autophagy, and Necroptosis

Med Sci Monit In Press; DOI: 10.12659/MSM.937766  

10 Aug 2022 : Database Analysis  

Use and Effects of Augmentation of Labor with Oxytocin: A Single-Center, Retrospective, Case-Control Study ...

Med Sci Monit In Press; DOI: 10.12659/MSM.937557  

Most Viewed Current Articles

30 Dec 2021 : Clinical Research  

Retrospective Study of Outcomes and Hospitalization Rates of Patients in Italy with a Confirmed Diagnosis o...

DOI :10.12659/MSM.935379

Med Sci Monit 2021; 27:e935379

13 Nov 2021 : Clinical Research  

Acceptance of COVID-19 Vaccination and Its Associated Factors Among Cancer Patients Attending the Oncology ...

DOI :10.12659/MSM.932788

Med Sci Monit 2021; 27:e932788

08 Mar 2022 : Review article  

A Review of the Potential Roles of Antioxidant and Anti-Inflammatory Pharmacological Approaches for the Man...

DOI :10.12659/MSM.936292

Med Sci Monit 2022; 28:e936292

01 Nov 2020 : Review article  

Long-Term Respiratory and Neurological Sequelae of COVID-19

DOI :10.12659/MSM.928996

Med Sci Monit 2020; 26:e928996

Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750