Logo Medical Science Monitor

Call: +1.631.470.9640
Closed: National Holiday

Contact Us

Logo Medical Science Monitor Logo Medical Science Monitor Logo Medical Science Monitor

01 September 2005

Activities of red blood cell anti-oxidative enzymes (SOD, GPx) and total anti-oxidativecapacity of serum (TAS) in men with coronary atherosclerosis and in healthy pilots.

Ewelina Zawadzka-Bartczak

Med Sci Monit 2005; 11(9): CR440-444 :: ID: 428453

Abstract

Background: Reactive oxygen species (ROS) have been proposed to play importantpathogenic roles, especially in harmful oxidative modifications of low-density cholesterol. Redox balancewithin the organism is largely determined by the activities of anti-oxidative enzymes of red blood cellsand by the total anti-oxidative capacity of the serum (TAS). Material/Methods: SOD and GPx activitiesand TAS in 13 men aged 42-65 years with coronary atherosclerosis (group I) were compared with those ofboth 15 clinically healthy pilots matched for age and lipid abnormalities (cholesterol and triglycerides)(group II) and 14 age-matched pilots without lipid abnormalities (group III). Results: There were statisticallysignificant differences in SOD and GPx activities and in TAS between the groups. Conclusions: 1. SODand GPx activities and TAS were lower in men with advanced coronary atherosclerosis that in age-matchedclinically healthy men with similar dyslipidemia and were even further decreased compared with clinicallyhealthy men without dyslipidemia. 2. The decrease in SOD and GPx activities and TAS in men with advancedcoronary atherosclerosis was more pronounced than the degree of hypercholesterolemia or hypertriglyceridemia.3. If hyperlipidemia and the activity of antioxidative enzymes and TAS were considered without referenceto other risk factors of atherosclerosis, it appeared that the decreases in SOD, GPx, and TAS may playa more important role in the development of the atherosclerotic process than isolated increases in freecholesterol or triglyceride levels.

Keywords: Aerospace Medicine, Antioxidants - metabolism, Case-Control Studies, Cholesterol - blood, Coronary Artery Disease - enzymology, Erythrocytes - enzymology, Glutathione Peroxidase - blood, Reactive Oxygen Species - blood, Superoxide Dismutase - blood, Triglycerides - blood

Add Comment 0 Comments

686 16

Editorial

01 May 2023 : Editorial  

Editorial: Twenty Years On from Sequencing the Human Genome, Personalized/Precision Oncology Prepares to Meet the Challenges of Checkpoint Inhibitor Therapy

Dinah V. Parums
Science Editor, Medical Science Monitor, International Scientific Information, Inc., Melville, NY, USA

DOI: 10.12659/MSM.940911

Med Sci Monit 2023; 29:e940911

In Press

28 May 2023 : Database Analysis  

Scientometric and Visualized Analysis of Intravoxel Incoherent Motion Magnetic Resonance Imaging: 1988-2021

Med Sci Monit In Press; DOI: 10.12659/MSM.938715  

25 May 2023 : Database Analysis  

The COVID-19 Crisis and the Incidence of Alcohol-Related Deaths in Poland

Med Sci Monit In Press; DOI: 10.12659/MSM.940904  

25 May 2023 : Review article  

A Review of Preclinical and Clinical Studies in Support of the Role of Non-Steroidal Anti-Inflammatory Drug...

Med Sci Monit In Press; DOI: 10.12659/MSM.940635  

25 May 2023 : Clinical Research  

Periapical Lesions and Missed Canals in Endodontically Treated Teeth: A Cone-Beam Computed Tomographic Stud...

Med Sci Monit In Press; DOI: 10.12659/MSM.940533  

Most Viewed Current Articles

13 Nov 2021 : Clinical Research  

Acceptance of COVID-19 Vaccination and Its Associated Factors Among Cancer Patients Attending the Oncology ...

DOI :10.12659/MSM.932788

Med Sci Monit 2021; 27:e932788

30 Dec 2021 : Clinical Research  

Retrospective Study of Outcomes and Hospitalization Rates of Patients in Italy with a Confirmed Diagnosis o...

DOI :10.12659/MSM.935379

Med Sci Monit 2021; 27:e935379

08 Mar 2022 : Review article  

A Review of the Potential Roles of Antioxidant and Anti-Inflammatory Pharmacological Approaches for the Man...

DOI :10.12659/MSM.936292

Med Sci Monit 2022; 28:e936292

01 Jan 2022 : Editorial  

Editorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Pa...

DOI :10.12659/MSM.935952

Med Sci Monit 2022; 28:e935952

Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750