01 September 2003
Role of respiratory syncytial virus In respiratory tract infections pathogenesis in infants and small children
Grażyna Łuczak, Ewa Kozielska, Joanna Tyl, Anna Borkowska, Anna Galińska, Wojciech Radys, Zbigniew BohdanMed Sci Monit 2003; 9(4): 44-47 :: ID: 428636
Abstract
Background: Respiratory Syncytial Virus (RSV) is a common etiological agent of respiratory infections in neonates and small chil-dren.The aim of the study was to evaluate: frequency and clinical outcome of RSV infections in children, risk factors and coincidence with atopy and humoral immunodeficiency. Material/Methods: Patient ’s history, changes on physical examination, laboratory investigation, chest x-ray, serum IgA, IgG, IgM, IgE levels and specific IgM and IgG antibodies against RSV were analysed in 160 children, aged 2 to 36 months, with respiratory infection.Results: RSV infection was diagnosed on the basis of specific anti-RSV IgM antibodies appearance or increasing anti-RSV IgG level. The group of 61 children with RSV infection included: 13 (21.3%) premature infants, 14 (22.7%) children less than 2 months old and 32 (52.3%) patients over 12 months of age. The main clinical manifestations were: wheezing (obturative) bronchitis (75.4%), pneumonia (44.3%) or both (32.8%). Eight cases of severe bronchiolitis among the youngest infants were noted. Leukocytosis was observed in 77% and increased CRP level in 23% of children. Serum IgA and IgM levels were normal in 82%, IgG in 95.1% and total IgE level in 47.5% of patients. Increased IgE level was observed in 52.5%. Only 26.2% of these children demonstrated clinical features of atopy.Conclusions: RSV infection, usually obturative bronchitis or pneumonia,is commonly observed in young children. Severe bronchi-olitis may occur. Coincidence frequency of RSV infection with total serum IgE elevation and atopy needs further investigation.
Keywords: RSV, Respiratory Tract Infections, Immunoglobulins, children
Editorial
01 November 2024 : Editorial
Editorial: Artificial Intelligence (AI), Digital Image Analysis, and the Future of Cancer Diagnosis and PrognosisDOI: 10.12659/MSM.947038
Med Sci Monit 2024; 30:e947038
In Press
Clinical Research
Plaque Removal and Gingival Bleeding Using Biodegradable Toothbrushes: Salvadora persica, Bamboo, and Nylo...Med Sci Monit In Press; DOI: 10.12659/MSM.944469
Clinical Research
Comparative Analysis of Extended Curettage with Plate Fixation and Extended Curettage with Intramedullary N...Med Sci Monit In Press; DOI: 10.12659/MSM.945157
Clinical Research
Clinical Outcomes of Talus Bone Marrow Edema: Comparing Plaster Cast, Crutches, and Walking Boot TreatmentsMed Sci Monit In Press; DOI: 10.12659/MSM.946072
Review article
Comprehensive Insights into Arecoline Hydrobromide: Pharmacology, Toxicity, and PharmacokineticsMed Sci Monit In Press; DOI: 10.12659/MSM.945582
Most Viewed Current Articles
17 Jan 2024 : Review article 6,263,065
Vaccination Guidelines for Pregnant Women: Addressing COVID-19 and the Omicron VariantDOI :10.12659/MSM.942799
Med Sci Monit 2024; 30:e942799
14 Dec 2022 : Clinical Research 1,908,785
Prevalence and Variability of Allergen-Specific Immunoglobulin E in Patients with Elevated Tryptase LevelsDOI :10.12659/MSM.937990
Med Sci Monit 2022; 28:e937990
16 May 2023 : Clinical Research 695,294
Electrophysiological Testing for an Auditory Processing Disorder and Reading Performance in 54 School Stude...DOI :10.12659/MSM.940387
Med Sci Monit 2023; 29:e940387
07 Jan 2022 : Meta-Analysis 260,437
Efficacy and Safety of Light Therapy as a Home Treatment for Motor and Non-Motor Symptoms of Parkinson Dise...DOI :10.12659/MSM.935074
Med Sci Monit 2022; 28:e935074