Logo Medical Science Monitor

Call: +1.631.470.9640
Mon - Fri 10:00 am - 02:00 pm EST

Contact Us

Logo Medical Science Monitor Logo Medical Science Monitor Logo Medical Science Monitor

01 November 2005

Changes in Body Composition and Insulin Sensitivity in Severely Obese Subjects After Laparoscopic Adjustable Silicone Gastric Banding (LASGB).

Gabriella Garrapa, Paola Canibus, Cristina Gatti, Milena Santangelo, Federica Frezza, Francesco Feliciotti, Marco Boscaro, Emanuela Faloia

DOI: 10.12659/MSM.430365

Med Sci Monit 2005; 11(11): CR522-528


Background: Laparoscopic adjustable silicone gastric banding (LASGB) isa viable therapeutic approach to achieve stable body weight reduction in severe obesity. The aim of thisstudy was to evaluate body composition and metabolic features in morbidly obese patients before and afterLASGB. Material/Methods: There were 15 severely obese patients (Ob) (M/F: 4/11; mean age: 32.5+/-3.8years) and 16 age- and sex-matched healthy lean controls (C) (M/F: 4/12; mean age: 39.5+/-2 years). Bodymass index (BMI), waist circumference, waist-to-hip ratio, blood pressure, lipid profile, serum glucoseand insulin during OGTT, and HOMA-IR were evaluated in all subjects. Body composition and fat distributionwere measured using dual energy X-ray absorptiometry (DEXA). Patients were assessed before and six monthsafter LASGB. Results: The obese subjects showed several metabolic alterations. There were also positivecorrelations between waist, fat mass (FM), and HOMA-IR at baseline. After LASGB, mean BMI fell from 42.2kg/m(2) to 33.2 kg/m(2); waist circumference and abdominal FM% decreased significantly. FM% declined,whereas FFM% increased. The ratio of FM loss to FFM loss was 3.7:1. Serum glucose and insulin levelsduring OGTT diminished slightly after weight loss and triglyceride levels fell dramatically. After LASGB,fasting insulin and HOMA-IR declined. Conclusions: LASGB induced a significant improvement in insulinsensitivity and a redistribution of body composition with a relative increase of FFM.

Keywords: Anthropometry, Absorptiometry, Photon, Body Composition, Gastroplasty - methods, Insulin Resistance, Laparoscopy, Obesity, Morbid - therapy, Silicones, Stomach - surgery, Weight Loss

Add Comment 0 Comments


01 May 2024 : Editorial  

Editorial: First Regulatory Approval for Adoptive Cell Therapy with Autologous Tumor-Infiltrating Lymphocytes (TILs) – Lifileucel (Amtagvi)

Dinah V. Parums

DOI: 10.12659/MSM.944927

Med Sci Monit 2024; 30:e944927

In Press

07 May 2024 : Clinical Research  

Treatment of AVN-Induced Proximal Pole Scaphoid Nonunion Using a Fifth and Fourth Extensor Compartmental Ar...

Med Sci Monit In Press; DOI: 10.12659/MSM.944553  

16 Mar 2024 : Clinical Research  

Diagnostic Efficiency of ACR-TIRADS Score for Differentiating Benign and Malignant Thyroid Nodules of Vario...

Med Sci Monit In Press; DOI: 10.12659/MSM.943228  

08 May 2024 : Clinical Research  

Effect of Individualized PEEP Guided by Driving Pressure on Diaphragm Function in Patients Undergoing Lapar...

Med Sci Monit In Press; DOI: 10.12659/MSM.944022  

21 Mar 2024 : Clinical Research  

Impact of Serum Vitamin D, B6, and B12 and Cognitive Functions on Quality of Life in Peri- and Postmenopaus...

Med Sci Monit In Press; DOI: 10.12659/MSM.943249  

Most Viewed Current Articles

17 Jan 2024 : Review article  

Vaccination Guidelines for Pregnant Women: Addressing COVID-19 and the Omicron Variant

DOI :10.12659/MSM.942799

Med Sci Monit 2024; 30:e942799


14 Dec 2022 : Clinical Research  

Prevalence and Variability of Allergen-Specific Immunoglobulin E in Patients with Elevated Tryptase Levels

DOI :10.12659/MSM.937990

Med Sci Monit 2022; 28:e937990


16 May 2023 : Clinical Research  

Electrophysiological Testing for an Auditory Processing Disorder and Reading Performance in 54 School Stude...

DOI :10.12659/MSM.940387

Med Sci Monit 2023; 29:e940387


01 Jan 2022 : Editorial  

Editorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Pa...

DOI :10.12659/MSM.935952

Med Sci Monit 2022; 28:e935952


Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750