01 December 2005
The impact of rosiglitazone on heat tolerance in patients with Type 2 Diabetes.
Jerrold Petrofsky, Scott Lee, Maria Cuneo-LibaronaMed Sci Monit 2005; 11(12): CR562-569 :: ID: 438852
Abstract
Background: Diabetes is associated with reduced tolerance to heat. Theinsulin sensitizer rosiglitazone (RSG), administered for glycemic control, has a secondary effect inincreasing vascular endothelial function. The hypothesis to be tested was if administration of rosiglitazonewould increase heat tolerance in people with diabetes. Material/Methods: Thirty subjects with diabetesand thirty control subjects were examined. A subset of 21 subjects with diabetes had RSG administeredat 4 mg per day for a period of 1 year. At 2 weeks, 4 weeks, 3 months, 6 months, and 1 year post administration,measurements were taken to assess any potential impact of this drug on thermoregulation. Parameters measuredwere sweat rate, skin temperature, body core temperature, and skin blood flow. Results: Results of theseexperiments showed that subjects with diabetes at baseline had 1) sensory impairment, 2) sweat glandimpairment 3) high skin temperatures, 4) and low blood flow reduction during heat exposure, all leadingto higher core temperature compared to controls subjects. After administration of rosiglitazone for 1year significant improvements in thermoregulation were observed. Trends for improvement in thermoregulationwere observed close to that of age matched control subjects. Conclusions: Heat tolerance can be improvedin people with diabetes when taking the insulin sensitizer RSG for Glycemic control, probably due toincreased endothelial cell function.
Keywords: Body Temperature Regulation - drug effects, Diabetes Mellitus, Type 2 - physiopathology, Hot Temperature, Hypoglycemic Agents - pharmacology, Skin Temperature - drug effects, Thiazolidinediones - pharmacology
Editorial
01 January 2023 : Editorial
Editorial: Current Status of Two Adjuvanted Malaria Vaccines and the World Health Organization (WHO) Strategy to Eradicate Malaria by 2030DOI: 10.12659/MSM.939357
Med Sci Monit 2023; 29:e939357
SARS-CoV-2/COVID-19
26 January 2023 : Editorial
Editorial: The XBB.1.5 (‘Kraken’) Subvariant of Omicron SARS-CoV-2 and its Rapid Global SpreadMed Sci Monit In Press; DOI: 10.12659/MSM.939580
19 January 2023 : Clinical Research
Evaluation of Health-Related Quality of Life and Mental Health in 729 Medical Students in Indonesia During ...Med Sci Monit In Press; DOI: 10.12659/MSM.938892
19 January 2023 : Clinical Research
Determining the Impact of the COVID-19 Pandemic on Dental Care in the Serbian Adult Population: An Online Q...Med Sci Monit 2023; 29:e939238
27 December 2022 : Clinical Research
Effect of Physiotherapy to Correct Rounded Shoulder Posture in 30 Patients During the COVID-19 Pandemic in ...Med Sci Monit 2022; 28:e938926
In Press
27 Jan 2023 : Database Analysis
Association Between Neutrophil-Lymphocyte Ratio and All-Cause Mortality in Critically Ill Patients with Chr...Med Sci Monit In Press; DOI: 10.12659/MSM.938554
27 Jan 2023 : Clinical Research
Proposal for a Simple Equation for Limb Muscle Weight CalculationMed Sci Monit In Press; DOI: 10.12659/MSM.938606
26 Jan 2023 : Editorial
Editorial: The XBB.1.5 (‘Kraken’) Subvariant of Omicron SARS-CoV-2 and its Rapid Global SpreadMed Sci Monit In Press; DOI: 10.12659/MSM.939580
20 Jan 2023 : Clinical Research
A Study of 42 Partially Edentulous Patients with Single-Crown Restorations and Implants to Compare Bone Los...Med Sci Monit In Press; DOI: 10.12659/MSM.939225
Most Viewed Current Articles
13 Nov 2021 : Clinical Research
Acceptance of COVID-19 Vaccination and Its Associated Factors Among Cancer Patients Attending the Oncology ...DOI :10.12659/MSM.932788
Med Sci Monit 2021; 27:e932788
30 Dec 2021 : Clinical Research
Retrospective Study of Outcomes and Hospitalization Rates of Patients in Italy with a Confirmed Diagnosis o...DOI :10.12659/MSM.935379
Med Sci Monit 2021; 27:e935379
08 Mar 2022 : Review article
A Review of the Potential Roles of Antioxidant and Anti-Inflammatory Pharmacological Approaches for the Man...DOI :10.12659/MSM.936292
Med Sci Monit 2022; 28:e936292
01 Jan 2022 : Editorial
Editorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Pa...DOI :10.12659/MSM.935952
Med Sci Monit 2022; 28:e935952