Logo Medical Science Monitor

Call: +1.631.470.9640
Mon - Fri 10:00 am - 02:00 pm EST

Contact Us

Logo Medical Science Monitor Logo Medical Science Monitor Logo Medical Science Monitor

01 December 2005

Dietary fats, fatty acids and insulin resistance: short review of a multifacetedconnection.

Marianne Haag, Nola G. Dippenaar

Med Sci Monit 2005; 11(12): RA359-367 :: ID: 438867

Abstract

Insulin resistance is a growing worldwide phenomenon, which progressivelydevelops over years, and finally, if unchecked, predisposes to cardiovascular disease and diabetes mellitustype 2. Insulin resistance is a generalized metabolic disorder characterized by inefficient insulin functionin skeletal muscle, liver and adipocytes. There is growing evidence that an increased free fatty acidlevel, and more importantly, the relative amounts of saturated and unsaturated fatty acids contributingto it, plays an important role in the development of insulin resistance. In turn, this is a reflectionof the composition of dietary fat. Ultimately both the dietary intake and plasma levels determine thefatty acid composition of cell membranes. Higher levels of membrane saturated fatty acids seem to greatlyimpair the action of insulin, whereas the presence of polyunsaturated fatty acids, especially of theomega-3 and -6 families, in contrast, improves insulin sensitivity.

Keywords: Dietary Fats - metabolism, Fatty Acids - metabolism, Food Habits, Insulin Resistance, Membrane Lipids - analysis, Metabolic Syndrome X - etiology

Add Comment 0 Comments

Editorial

01 April 2025 : Editorial  

Editorial: Rapid Testing for the Avian Influenza A(H5N1) Virus is Urgently Required as Infections in Poultry and Dairy Cows are on the Rise, and so is Transmission to Humans

Dinah V. Parums

DOI: 10.12659/MSM.949109

Med Sci Monit 2025; 31:e949109

0:00

In Press

Clinical Research  

Dental Students’ Opinions on Use of Artificial Intelligence: A Survey Study

Med Sci Monit In Press; DOI: 10.12659/MSM.947658  

0:00

Database Analysis  

Defining Effect Size Standards in Temporomandibular Joint and Masticatory Muscle Research

Med Sci Monit In Press; DOI: 10.12659/MSM.948365  

0:00

Clinical Research  

Evaluating Factors Influencing Periodontal Bone Loss Using Cone Beam Computed Tomography: A Retrospective S...

Med Sci Monit In Press; DOI: 10.12659/MSM.947759  

Database Analysis  

Prognostic Significance and Immune Environment Analysis Using PANoptosis Molecular Clustering in Gastric Ca...

Med Sci Monit In Press; DOI: 10.12659/MSM.947710  

Most Viewed Current Articles

17 Jan 2024 : Review article   8,225,070

Vaccination Guidelines for Pregnant Women: Addressing COVID-19 and the Omicron Variant

DOI :10.12659/MSM.942799

Med Sci Monit 2024; 30:e942799

0:00

16 May 2023 : Clinical Research   703,027

Electrophysiological Testing for an Auditory Processing Disorder and Reading Performance in 54 School Stude...

DOI :10.12659/MSM.940387

Med Sci Monit 2023; 29:e940387

0:00

01 Mar 2024 : Editorial   30,424

Editorial: First Regulatory Approvals for CRISPR-Cas9 Therapeutic Gene Editing for Sickle Cell Disease and ...

DOI :10.12659/MSM.944204

Med Sci Monit 2024; 30:e944204

0:00

28 Jan 2024 : Review article   24,191

A Review of IgA Vasculitis (Henoch-Schönlein Purpura) Past, Present, and Future

DOI :10.12659/MSM.943912

Med Sci Monit 2024; 30:e943912

0:00

Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750