Logo Medical Science Monitor

Call: +1.631.470.9640
Mon - Fri 10:00 am - 02:00 pm EST

Contact Us

Logo Medical Science Monitor Logo Medical Science Monitor Logo Medical Science Monitor

01 March 2006

Glutathione metabolism of filarial worms: A vulnerable target for the designand synthesis of new antifilarial agents.

Sapna Gupta, Arvind Kumar Srivastava

Med Sci Monit 2006; 12(3): HY1-9 :: ID: 447100


The main problem regarding the chemotherapy of filariasis is that no safeand effective drug is available yet to combat the adult human filarial worms. One of the main reasonsis the prolonged existence, i.e. survival of filarial worms in mammalian hosts for many years, and havinga very strong antioxidant system. Glutathione (GSH) has been identified as an important part of the antioxidantsystem of many, if not all, living cells and, together with glutathione reductase (GR), it maintainsthe correct intracellular redox balance. It protects the cell against oxidative damage by non-enzymaticscavenging of free radicals and by enzymatic neutralization of toxic hydrogen peroxide, lipid hydroperoxides,and derivatives by glutathione-dependent peroxidases (GPXs) and glutathione-S-transferases (GSTs). Workin this direction reveals that filarial worms can synthesize and recycle GSH, and its depletion may beuseful in chemotherapeutic situations in which the cells to be killed and the cells to be spared havesubstantially different quantitative requirements for GSH. All normal mammalian cells have a considerableamount of GSH, whereas filarial worms may have GSH concentrations close to that required for their survivaland, therefore, a little manipulation of the glutathione metabolism of filarial worms may have drasticconsequences. The present review details the application of the glutathione metabolism of filarial wormsas a target for the design and synthesis of new antifilarial agents.

Keywords: Filaricides - chemistry, Filariasis - drug therapy, Antioxidants - metabolism, Filarioidea - metabolism, Glutamate-Cysteine Ligase - metabolism, Glutathione - metabolism, Glutathione Peroxidase - metabolism, Glutathione Reductase - metabolism, Glutathione Transferase - metabolism, Models, Biological



01 February 2023 : Editorial  

Editorial: The XBB.1.5 (‘Kraken’) Subvariant of Omicron SARS-CoV-2 and its Rapid Global Spread

Dinah V. Parums
Science Editor, Medical Science Monitor, International Scientific Information, Inc., Melville, NY, USA

DOI: 10.12659/MSM.939580

Med Sci Monit 2023; 29:e939580


19 January 2023 : Clinical Research  

Evaluation of Health-Related Quality of Life and Mental Health in 729 Medical Students in Indonesia During ...

Med Sci Monit In Press; DOI: 10.12659/MSM.938892  

27 December 2022 : Clinical Research  

Effect of Physiotherapy to Correct Rounded Shoulder Posture in 30 Patients During the COVID-19 Pandemic in ...

Med Sci Monit 2022; 28:e938926

10 December 2022 : Clinical Research  

Retrospective Study to Identify Risk Factors for Severe Disease and Mortality Using the Modified Early Warn...

Med Sci Monit 2022; 28:e938647

In Press

01 Feb 2023 : Clinical Research  

Comparison of 3 Enzyme-Linked Immunoassay Methods to Evaluate Serum Concentrations of Infliximab and Antibo...

Med Sci Monit In Press; DOI: 10.12659/MSM.939084  

31 Jan 2023 : Clinical Research  

Balloon Dilation Eustachian Tuboplasty Combined with Tympanotomy Tube Insertion for Treatment of Refractory...

Med Sci Monit In Press; DOI: 10.12659/MSM.938879  

31 Jan 2023 : Clinical Research  

Comparison of Vision Correction and Corneal Thickness at 180-Day Follow-Up After Femtosecond Laser-Assisted...

Med Sci Monit In Press; DOI: 10.12659/MSM.939099  

30 Jan 2023 : Clinical Research  

Splenic Artery Steal Syndrome in Patients with Liver Cirrhosis: A Retrospective Clinical Study

Med Sci Monit In Press; DOI: 10.12659/MSM.938998  

Most Viewed Current Articles

13 Nov 2021 : Clinical Research  

Acceptance of COVID-19 Vaccination and Its Associated Factors Among Cancer Patients Attending the Oncology ...

DOI :10.12659/MSM.932788

Med Sci Monit 2021; 27:e932788

30 Dec 2021 : Clinical Research  

Retrospective Study of Outcomes and Hospitalization Rates of Patients in Italy with a Confirmed Diagnosis o...

DOI :10.12659/MSM.935379

Med Sci Monit 2021; 27:e935379

08 Mar 2022 : Review article  

A Review of the Potential Roles of Antioxidant and Anti-Inflammatory Pharmacological Approaches for the Man...

DOI :10.12659/MSM.936292

Med Sci Monit 2022; 28:e936292

01 Jan 2022 : Editorial  

Editorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Pa...

DOI :10.12659/MSM.935952

Med Sci Monit 2022; 28:e935952

Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750