Logo Medical Science Monitor

Call: +1.631.470.9640
Mon - Fri 10:00 am - 02:00 pm EST

Contact Us

Logo Medical Science Monitor Logo Medical Science Monitor Logo Medical Science Monitor

01 March 2006

Cellular mechanisms of lead neurotoxicity.

Anibal Garza, Rosario Vega, Enrique Soto

Med Sci Monit 2006; 12(3): RA57-65 :: ID: 447121

Abstract

Lead (Pb[sup]2+[/sup]), a heavy metal, has been used by humans for many technologicalpurposes, which is the main reason for its present widespread distribution. Although various actionshave been taken to decrease the use and distribution of lead in the environment, it remains a significanthealth hazard. The toxic mechanism of lead is caused by its ability to substitute for other polyvalentcations (particularly divalent cations, such as calcium [Ca[sup]2+[/sup]] and zinc [Zn[sup]2+[/sup]]) in the molecularmachinery of living organisms. These interactions allow lead to affect different biologically significantprocesses, including metal transport, energy metabolism, apoptosis, ionic conduction, cell adhesion,inter- and intracellular signaling, diverse enzymatic processes, protein maturation, and genetic regulation.Membrane ionic channels and signaling molecules seem to be one of the most relevant molecular targetscontributing to lead's neurotoxicity; the developing central nervous system is particularly susceptible.At critical times in development, lead may have a disorganizing influence with long-lasting effects thatmay continue into teenage years and beyond. Pediatric lead poisoning is more common than adult lead poisoning,and its effects may occur at reduced blood levels with subclinical symptoms, thus a high index of suspicionis necessary for physicians when dealing with pediatric patients. Long-term effects of lead poisoningmay produce cognitive and motor impairment, with behavioral alterations. This review is centered on thedescription of the molecular mechanisms of lead toxicity and its repercussions on cellular functions.

Keywords: Calcium Channels - toxicity, Calcium - metabolism, Lead - toxicity, Lead Poisoning - metabolism, Neurotoxicity Syndromes - metabolism, Zinc - metabolism

0 Comments

Editorial

01 February 2023 : Editorial  

Editorial: The XBB.1.5 (‘Kraken’) Subvariant of Omicron SARS-CoV-2 and its Rapid Global Spread

Dinah V. Parums
Science Editor, Medical Science Monitor, International Scientific Information, Inc., Melville, NY, USA

DOI: 10.12659/MSM.939580

Med Sci Monit 2023; 29:e939580

SARS-CoV-2/COVID-19

19 January 2023 : Clinical Research  

Evaluation of Health-Related Quality of Life and Mental Health in 729 Medical Students in Indonesia During ...

Med Sci Monit In Press; DOI: 10.12659/MSM.938892  

27 December 2022 : Clinical Research  

Effect of Physiotherapy to Correct Rounded Shoulder Posture in 30 Patients During the COVID-19 Pandemic in ...

Med Sci Monit 2022; 28:e938926

10 December 2022 : Clinical Research  

Retrospective Study to Identify Risk Factors for Severe Disease and Mortality Using the Modified Early Warn...

Med Sci Monit 2022; 28:e938647

In Press

06 Feb 2023 : Clinical Research  

Double C-Arm Digital Subtraction Angiography Guidance During Transjugular Intrahepatic Portosystemic Shunt ...

Med Sci Monit In Press; DOI: 10.12659/MSM.938912  

06 Feb 2023 : Review article  

Evolution of Hybrid Intelligence and Its Application in Evidence-Based Medicine: A Review

Med Sci Monit In Press; DOI: 10.12659/MSM.939366  

03 Feb 2023 : Clinical Research  

Treatment of Gingival Recession Defects with Pouch and Tunnel Technique Using Connective Tissue Graft and L...

Med Sci Monit In Press; DOI: 10.12659/MSM.938865  

02 Feb 2023 : Clinical Research  

Online Questionnaire-Based Study to Evaluate the Attitudes and Use of Rubber Dental Dams by Saudi Dental Pr...

Med Sci Monit In Press; DOI: 10.12659/MSM.938672  

Most Viewed Current Articles

13 Nov 2021 : Clinical Research  

Acceptance of COVID-19 Vaccination and Its Associated Factors Among Cancer Patients Attending the Oncology ...

DOI :10.12659/MSM.932788

Med Sci Monit 2021; 27:e932788

30 Dec 2021 : Clinical Research  

Retrospective Study of Outcomes and Hospitalization Rates of Patients in Italy with a Confirmed Diagnosis o...

DOI :10.12659/MSM.935379

Med Sci Monit 2021; 27:e935379

08 Mar 2022 : Review article  

A Review of the Potential Roles of Antioxidant and Anti-Inflammatory Pharmacological Approaches for the Man...

DOI :10.12659/MSM.936292

Med Sci Monit 2022; 28:e936292

01 Jan 2022 : Editorial  

Editorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Pa...

DOI :10.12659/MSM.935952

Med Sci Monit 2022; 28:e935952

Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750