Logo Medical Science Monitor

Call: +1.631.470.9640
Mon - Fri 10:00 am - 02:00 pm EST

Contact Us

Logo Medical Science Monitor Logo Medical Science Monitor Logo Medical Science Monitor

10 April 2006

Maternal age at delivery and order of birth are risk factors for type 1 diabetesmellitus in Upper Silesia, Poland.

Joanna Polańska, Przemysława Jarosz-Chobot

Med Sci Monit 2006; 12(4): CR173-176 :: ID: 448903

Abstract

Background: Parental age and birth order as risk factors for childhoodtype 1 diabetes mellitus were investigated using data from the Regional Diabetic Center for Upper Silesia,Poland, in a population-based study of 398 children with type 1 DM aged 0-14 years born between 1979-1996.Material/Methods: Noting differences in the proportions of children of different birth order betweencases and controls, the data were stratified by birth order. For each stratum, odds ratios and their95% confidence intervals were calculated to assess risks related to the mother's age. The homogeneityof the odds ratios related to the mother's age between strata was evaluated by the Mantel-Haenszel method.Risks related to mother's age and birth order were also estimated jointly by multivariable logistic regression.Results: Decreased risk in later children compared with firstborns was noted. Increased maternal agewas found to be a risk factor for type 1 DM. An increase in the mother's age by one year increases therisk of the child being affected by type 1 DM 1.07 times, and children born as the nth in the familyare 1.59 times less exposed to the same risk than those born as the (n-1)th. Conclusions: Children ofdifferent birth order have different risks of being affected by type 1 DM. Increased maternal age atthe time of delivery is a risk factor for type 1 DM in Upper Silesia, Poland. To avoid bias in estimatingrisks, the mother's age and child's sequence number should be analyzed jointly.

Keywords: Risk Factors, Pregnancy, Poland, Odds Ratio, Maternal Age, Infant, Newborn, Birth Order, Diabetes Mellitus, Type 1 - etiology, Child, Preschool, Child, Case-Control Studies, Adolescent

Add Comment 0 Comments

Editorial

01 February 2024 : Editorial  

Editorial: Global Health Concerns as Vaccine-Preventable Infections Including SARS-CoV-2 (JN.1), Influenza, Respiratory Syncytial Virus (RSV), and Measles Continue to Rise

Dinah V. Parums

DOI: 10.12659/MSM.943911

Med Sci Monit 2024; 30:e943911

0:00

In Press

08 Feb 2024 : Clinical Research  

Predictors of Mortality in Veterans with Amyotrophic Lateral Sclerosis: Respiratory Status and Speech Disor...

Med Sci Monit In Press; DOI: 10.12659/MSM.943288  

0:00

25 Feb 2024 : Clinical Research  

Patterns and Outcomes of Traumatic Suicides: A Retrospective Study of 132 Patients Admitted to a Turkish Me...

Med Sci Monit In Press; DOI: 10.12659/MSM.943505  

0:00

01 Feb 2024 : Review article  

Review of the Evaluation of Pulmonary Hypoplasia as an Important Determinant of Clinical Outcomes in Infant...

Med Sci Monit In Press; DOI: 10.12659/MSM.943259  

0:00

19 Feb 2024 : Clinical Research  

Diagnostic Accuracy of Ileocolic Artery and Vein Diameter for Acute Appendicitis

Med Sci Monit In Press; DOI: 10.12659/MSM.943846  

Most Viewed Current Articles

16 May 2023 : Clinical Research  

Electrophysiological Testing for an Auditory Processing Disorder and Reading Performance in 54 School Stude...

DOI :10.12659/MSM.940387

Med Sci Monit 2023; 29:e940387

0:00

17 Jan 2024 : Review article  

Vaccination Guidelines for Pregnant Women: Addressing COVID-19 and the Omicron Variant

DOI :10.12659/MSM.942799

Med Sci Monit 2024; 30:e942799

0:00

14 Dec 2022 : Clinical Research  

Prevalence and Variability of Allergen-Specific Immunoglobulin E in Patients with Elevated Tryptase Levels

DOI :10.12659/MSM.937990

Med Sci Monit 2022; 28:e937990

0:00

01 Jan 2022 : Editorial  

Editorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Pa...

DOI :10.12659/MSM.935952

Med Sci Monit 2022; 28:e935952

0:00

Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750