Logo Medical Science Monitor

Call: +1.631.470.9640
Mon - Fri 10:00 am - 02:00 pm EST

Contact Us

Logo Medical Science Monitor Logo Medical Science Monitor Logo Medical Science Monitor

10 April 2006

Derivation of embryonic stem cells for cellular therapy: Challenges and newstrategies.

Philippe Taupin

Med Sci Monit 2006; 12(4): RA75-78 :: ID: 448936

Abstract

Cellular therapy is the replacement of unhealthy or damaged cells or tissuesby new ones. Embryonic stem (ES) cells are undifferentiated cells that can generate all the cell typesof the body, and therefore hold the potential to cure a broad range of diseases and injuries, rangingfrom diabetis, liver and heart diseases, to neurological diseases, such as Alzheimer's and Parkinson'sdiseases. The derivation of human ES (hES) cells has been a major step toward bringing ES cell researchto therapy. However, there are several challenges to the advent of ES cell research to therapy. Amongthem, the derivation of hES cell lines devoid of animal contaminants, the maintenance of their normalkaryotypes, their potentials to form tumors upon grafting, and the derivation of isogenic hES cell lines.Stringent ethical and political guidelines are also limiting the use of human embryos for research, therebylimiting progress in ES cell research. Recently, several investigators have devised protocols to derivehES cells free of feeder layer and animal serum, reported that some established cell lines remain stableovertime, pre-differentiated ES cells in vitro to circumvent the risk of tumor formation, and derivedES cell lines without destroying embryos. In this manuscript, we will review and discuss these developmentsthat may unlock ES cell research and therapy.

Keywords: Cell Differentiation, Cell Culture Techniques, Cell Line, Cloning, Organism - ethics, Nuclear Transfer Techniques, Stem Cells - cytology

0 Comments

Editorial

15 August 2022 : Editorial  

Editorial: The Metabolic (Dysfunction) Associated Fatty Liver Disease (MAFLD)-Non-Alcoholic Fatty Liver Disease (NAFLD) Debate: A Forced Consensus and The Risk of a World Divide

Nahum Méndez-Sánchez, Ming-Hua Zheng, Takumi Kawaguchi, Shiv K. Sarin
Liver Research Unit, Medica Sur Clinic & Foundation and Faculty of Medicine, National Autonomous University of Mexico, Mexico City, Mexico

DOI: 10.12659/MSM.938080

Med Sci Monit 2022; 28:e938080

In Press

12 Aug 2022 : Clinical Research  

Risk Factors and Pathogen Spectrum in Continuous Ambulatory Peritoneal Dialysis-Associated Peritonitis: A S...

Med Sci Monit In Press; DOI: 10.12659/MSM.937112  

11 Aug 2022 : Meta-Analysis  

Optimal Surgical Treatment Method for Anterior Cruciate Ligament Rupture: Results from a Network Meta-Analysis

Med Sci Monit In Press; DOI: 10.12659/MSM.937118  

10 Aug 2022 : Review article  

Programmed Cell Death in Diabetic Nephropathy: A Review of Apoptosis, Autophagy, and Necroptosis

Med Sci Monit In Press; DOI: 10.12659/MSM.937766  

10 Aug 2022 : Database Analysis  

Use and Effects of Augmentation of Labor with Oxytocin: A Single-Center, Retrospective, Case-Control Study ...

Med Sci Monit In Press; DOI: 10.12659/MSM.937557  

Most Viewed Current Articles

30 Dec 2021 : Clinical Research  

Retrospective Study of Outcomes and Hospitalization Rates of Patients in Italy with a Confirmed Diagnosis o...

DOI :10.12659/MSM.935379

Med Sci Monit 2021; 27:e935379

13 Nov 2021 : Clinical Research  

Acceptance of COVID-19 Vaccination and Its Associated Factors Among Cancer Patients Attending the Oncology ...

DOI :10.12659/MSM.932788

Med Sci Monit 2021; 27:e932788

08 Mar 2022 : Review article  

A Review of the Potential Roles of Antioxidant and Anti-Inflammatory Pharmacological Approaches for the Man...

DOI :10.12659/MSM.936292

Med Sci Monit 2022; 28:e936292

01 Nov 2020 : Review article  

Long-Term Respiratory and Neurological Sequelae of COVID-19

DOI :10.12659/MSM.928996

Med Sci Monit 2020; 26:e928996

Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750