Logo Medical Science Monitor

Call: +1.631.470.9640
Mon - Fri 10:00 am - 02:00 pm EST

Contact Us

Logo Medical Science Monitor Logo Medical Science Monitor Logo Medical Science Monitor

01 May 2006

Bifenthrin causes neurite retraction in the absence of cell death: A modelfor pesticide associated neurodegeneration.

Avishek Nandi, Daljit Chandi, Rethabile Lechesa, Stephen C. Pryor, Ashlea McLaughlin, Josephine A. Bonventre, Katherine Flynn, Benjamin S. Weeks

Med Sci Monit 2006; 12(5): BR169-173 :: ID: 450282


Background: Bifenthrin is a synthetic pyrethroid insecticide derivativeof naturally occurring pyrethrins from chrysanthemum flowers. Bifenthrin is considered relatively safeand therefore incorporated as the active ingredient in preparations sold over the counter for householduse. Recent studies have raised concern that chronic exposure to pesticides in the home setting may increasethe risk for neurodegenerative diseases. To address this concer, in the present study, bifenthrin isadded to pre-differentiated PC12 and effect of bifenthrin on the retraction of existing neurites is observeda model for neurodegeneration. Material/Methods: PC12 cells were differentiated with nerve growth factorfor twenty-four hours and then treated with what was determined to be a sublethal dose of bifenthrinfor up to an additional 48 hours. The percent of cells with neurites was assessed at various times beforeand after nerve growth factor treatment. Bifenthrin toxicity was determined using trypan blue exclusion.Results: Bifenthrin was not toxic to PC12 cells at concentrations ranging from 1x10[sup]-10[/sup] M to 1x10[sup]-4[/sup]M. Twenty-four hours after nerve growth factor treatment, a maximum percent of cells had formed neuritesand with a treatment of 1x10[sup]-5[/sup] M bifenthrin, approximately 80% of these neurites retracted in within12 additional hours and almost all neurites had retracted within 48 hours. Trypan exclusion showed thatthese cells were viable. Conclusions: These data show that bifenthrin can stimulate the retraction ofneurites in the absence of frank toxicity.

Keywords: Cell Survival - drug effects, Insecticides - toxicity, Lindane - toxicity, Models, Neurological, Nerve Degeneration - pathology, Nerve Growth Factor - pharmacology, Neurites - pathology, Neurons - pathology, Pyrethrins - toxicity

Add Comment 0 Comments


01 May 2024 : Editorial  

Editorial: First Regulatory Approval for Adoptive Cell Therapy with Autologous Tumor-Infiltrating Lymphocytes (TILs) – Lifileucel (Amtagvi)

Dinah V. Parums

DOI: 10.12659/MSM.944927

Med Sci Monit 2024; 30:e944927

In Press

Database Analysis  

Long-Term Prognosis of Patients Undergoing Percutaneous Coronary Intervention: The Impact of Serum Creatini...

Med Sci Monit In Press; DOI: 10.12659/MSM.943063  

Database Analysis  

Maternal Exposure to Environmental Air Pollution and Premature Rupture of Membranes: Evidence from Southern...

Med Sci Monit In Press; DOI: 10.12659/MSM.943601  

Animal Research  

Enhanced Bone Healing Through Systemic Capsaicin Administration: An Experimental Study on Wistar Rats

Med Sci Monit In Press; DOI: 10.12659/MSM.942485  

Clinical Research  

Differential Inflammatory Responses in Adult and Pediatric COVID-19 Patients: Implications for Long-Term Co...

Med Sci Monit In Press; DOI: 10.12659/MSM.944052  

Most Viewed Current Articles

17 Jan 2024 : Review article  

Vaccination Guidelines for Pregnant Women: Addressing COVID-19 and the Omicron Variant

DOI :10.12659/MSM.942799

Med Sci Monit 2024; 30:e942799


14 Dec 2022 : Clinical Research  

Prevalence and Variability of Allergen-Specific Immunoglobulin E in Patients with Elevated Tryptase Levels

DOI :10.12659/MSM.937990

Med Sci Monit 2022; 28:e937990


16 May 2023 : Clinical Research  

Electrophysiological Testing for an Auditory Processing Disorder and Reading Performance in 54 School Stude...

DOI :10.12659/MSM.940387

Med Sci Monit 2023; 29:e940387


01 Jan 2022 : Editorial  

Editorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Pa...

DOI :10.12659/MSM.935952

Med Sci Monit 2022; 28:e935952


Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750